Cannabinoid actions on neural stem cells: implications for pathophysiology

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Rui S.
Data de Publicação: 2019
Outros Autores: Lourenço, Diogo M., Paulo, Sara L, Mateus, Joana, Ferreira, Miguel F., Mouro, Francisco, Moreira, João B., Ribeiro, Filipa, Sebastião, Ana M, Xapelli, Sara
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49114
Resumo: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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spelling Cannabinoid actions on neural stem cells: implications for pathophysiologyCannabinoidsNeural stem cellsNeurogenesisRegenerationPathophysiology© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).With the increase of life expectancy, neurodegenerative disorders are becoming not only a health but also a social burden worldwide. However, due to the multitude of pathophysiological disease states, current treatments fail to meet the desired outcomes. Therefore, there is a need for new therapeutic strategies focusing on more integrated, personalized and effective approaches. The prospect of using neural stem cells (NSC) as regenerative therapies is very promising, however several issues still need to be addressed. In particular, the potential actions of pharmacological agents used to modulate NSC activity are highly relevant. With the ongoing discussion of cannabinoid usage for medical purposes and reports drawing attention to the effects of cannabinoids on NSC regulation, there is an enormous, and yet, uncovered potential for cannabinoids as treatment options for several neurological disorders, specifically when combined with stem cell therapy. In this manuscript, we review in detail how cannabinoids act as potent regulators of NSC biology and their potential to modulate several neurogenic features in the context of pathophysiology.This work was supported by IF/01227/2015 and UID/BIM/50005/2019, projeto financiado pela Fundação para a Ciência e a Tecnologia (FCT)/ Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) através de Fundos do Orçamento de Estado. R.S.R. (SFRH/BD/129710/2017), D.M.L. (PD/BD/141784/2018), F.F.R. (SFRH/BD/74662/2010), F.M.M. (IMM/CT/8-2018) were in receipt of a fellowship from FCT.MDPIRepositório da Universidade de LisboaRodrigues, Rui S.Lourenço, Diogo M.Paulo, Sara LMateus, JoanaFerreira, Miguel F.Mouro, FranciscoMoreira, João B.Ribeiro, FilipaSebastião, Ana MXapelli, Sara2021-07-26T13:07:07Z2019-04-052019-04-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49114engMolecules. 2019 Apr 5;24(7):135010.3390/molecules240713501420-3049info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:52:29Zoai:repositorio.ul.pt:10451/49114Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:41.141576Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Cannabinoid actions on neural stem cells: implications for pathophysiology
title Cannabinoid actions on neural stem cells: implications for pathophysiology
spellingShingle Cannabinoid actions on neural stem cells: implications for pathophysiology
Rodrigues, Rui S.
Cannabinoids
Neural stem cells
Neurogenesis
Regeneration
Pathophysiology
title_short Cannabinoid actions on neural stem cells: implications for pathophysiology
title_full Cannabinoid actions on neural stem cells: implications for pathophysiology
title_fullStr Cannabinoid actions on neural stem cells: implications for pathophysiology
title_full_unstemmed Cannabinoid actions on neural stem cells: implications for pathophysiology
title_sort Cannabinoid actions on neural stem cells: implications for pathophysiology
author Rodrigues, Rui S.
author_facet Rodrigues, Rui S.
Lourenço, Diogo M.
Paulo, Sara L
Mateus, Joana
Ferreira, Miguel F.
Mouro, Francisco
Moreira, João B.
Ribeiro, Filipa
Sebastião, Ana M
Xapelli, Sara
author_role author
author2 Lourenço, Diogo M.
Paulo, Sara L
Mateus, Joana
Ferreira, Miguel F.
Mouro, Francisco
Moreira, João B.
Ribeiro, Filipa
Sebastião, Ana M
Xapelli, Sara
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Rodrigues, Rui S.
Lourenço, Diogo M.
Paulo, Sara L
Mateus, Joana
Ferreira, Miguel F.
Mouro, Francisco
Moreira, João B.
Ribeiro, Filipa
Sebastião, Ana M
Xapelli, Sara
dc.subject.por.fl_str_mv Cannabinoids
Neural stem cells
Neurogenesis
Regeneration
Pathophysiology
topic Cannabinoids
Neural stem cells
Neurogenesis
Regeneration
Pathophysiology
description © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2019
dc.date.none.fl_str_mv 2019-04-05
2019-04-05T00:00:00Z
2021-07-26T13:07:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49114
url http://hdl.handle.net/10451/49114
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Molecules. 2019 Apr 5;24(7):1350
10.3390/molecules24071350
1420-3049
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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