Understanding the mechanisms of lung mechanical stress
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000600001 |
Resumo: | Physical forces affect both the function and phenotype of cells in the lung. Bronchial, alveolar, and other parenchymal cells, as well as fibroblasts and macrophages, are normally subjected to a variety of passive and active mechanical forces associated with lung inflation and vascular perfusion as a result of the dynamic nature of lung function. These forces include changes in stress (force per unit area) or strain (any forced change in length in relation to the initial length) and shear stress (the stress component parallel to a given surface). The responses of cells to mechanical forces are the result of the cell's ability to sense and transduce these stimuli into intracellular signaling pathways able to communicate the information to its interior. This review will focus on the modulation of intracellular pathways by lung mechanical forces and the intercellular signaling. A better understanding of the mechanisms by which lung cells transduce physical forces into biochemical and biological signals is of key importance for identifying targets for the treatment and prevention of physical force-related disorders. |
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Understanding the mechanisms of lung mechanical stressMechanical forcesMechanosensorsMechanotransductionCell-cell interactionsCytokinesExtracellular matrixPhysical forces affect both the function and phenotype of cells in the lung. Bronchial, alveolar, and other parenchymal cells, as well as fibroblasts and macrophages, are normally subjected to a variety of passive and active mechanical forces associated with lung inflation and vascular perfusion as a result of the dynamic nature of lung function. These forces include changes in stress (force per unit area) or strain (any forced change in length in relation to the initial length) and shear stress (the stress component parallel to a given surface). The responses of cells to mechanical forces are the result of the cell's ability to sense and transduce these stimuli into intracellular signaling pathways able to communicate the information to its interior. This review will focus on the modulation of intracellular pathways by lung mechanical forces and the intercellular signaling. A better understanding of the mechanisms by which lung cells transduce physical forces into biochemical and biological signals is of key importance for identifying targets for the treatment and prevention of physical force-related disorders.Associação Brasileira de Divulgação Científica2006-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000600001Brazilian Journal of Medical and Biological Research v.39 n.6 2006reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2006000600001info:eu-repo/semantics/openAccessGarcia,C.S.N.B.Prota,L.F.M.Morales,M.M.Romero,P.V.Zin,W.A.Rocco,P.R.M.eng2006-05-29T00:00:00Zoai:scielo:S0100-879X2006000600001Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2006-05-29T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Understanding the mechanisms of lung mechanical stress |
title |
Understanding the mechanisms of lung mechanical stress |
spellingShingle |
Understanding the mechanisms of lung mechanical stress Garcia,C.S.N.B. Mechanical forces Mechanosensors Mechanotransduction Cell-cell interactions Cytokines Extracellular matrix |
title_short |
Understanding the mechanisms of lung mechanical stress |
title_full |
Understanding the mechanisms of lung mechanical stress |
title_fullStr |
Understanding the mechanisms of lung mechanical stress |
title_full_unstemmed |
Understanding the mechanisms of lung mechanical stress |
title_sort |
Understanding the mechanisms of lung mechanical stress |
author |
Garcia,C.S.N.B. |
author_facet |
Garcia,C.S.N.B. Prota,L.F.M. Morales,M.M. Romero,P.V. Zin,W.A. Rocco,P.R.M. |
author_role |
author |
author2 |
Prota,L.F.M. Morales,M.M. Romero,P.V. Zin,W.A. Rocco,P.R.M. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Garcia,C.S.N.B. Prota,L.F.M. Morales,M.M. Romero,P.V. Zin,W.A. Rocco,P.R.M. |
dc.subject.por.fl_str_mv |
Mechanical forces Mechanosensors Mechanotransduction Cell-cell interactions Cytokines Extracellular matrix |
topic |
Mechanical forces Mechanosensors Mechanotransduction Cell-cell interactions Cytokines Extracellular matrix |
description |
Physical forces affect both the function and phenotype of cells in the lung. Bronchial, alveolar, and other parenchymal cells, as well as fibroblasts and macrophages, are normally subjected to a variety of passive and active mechanical forces associated with lung inflation and vascular perfusion as a result of the dynamic nature of lung function. These forces include changes in stress (force per unit area) or strain (any forced change in length in relation to the initial length) and shear stress (the stress component parallel to a given surface). The responses of cells to mechanical forces are the result of the cell's ability to sense and transduce these stimuli into intracellular signaling pathways able to communicate the information to its interior. This review will focus on the modulation of intracellular pathways by lung mechanical forces and the intercellular signaling. A better understanding of the mechanisms by which lung cells transduce physical forces into biochemical and biological signals is of key importance for identifying targets for the treatment and prevention of physical force-related disorders. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000600001 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000600001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X2006000600001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.39 n.6 2006 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302934627123200 |