Triorganotin as a compound with potential reproductive toxicity in mammals
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900018 |
Resumo: | Organotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive function. |
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Brazilian Journal of Medical and Biological Research |
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Triorganotin as a compound with potential reproductive toxicity in mammalsTributyltinTriphenyltinEndocrine disruptorAromataseImposexMammalian reproductive organsOrganotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive function.Associação Brasileira de Divulgação Científica2011-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900018Brazilian Journal of Medical and Biological Research v.44 n.9 2011reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2011007500110info:eu-repo/semantics/openAccessDelgado Filho,V.S.Lopes,P.F.I.Podratz,P.L.Graceli,J.B.eng2011-09-30T00:00:00Zoai:scielo:S0100-879X2011000900018Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2011-09-30T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Triorganotin as a compound with potential reproductive toxicity in mammals |
title |
Triorganotin as a compound with potential reproductive toxicity in mammals |
spellingShingle |
Triorganotin as a compound with potential reproductive toxicity in mammals Delgado Filho,V.S. Tributyltin Triphenyltin Endocrine disruptor Aromatase Imposex Mammalian reproductive organs |
title_short |
Triorganotin as a compound with potential reproductive toxicity in mammals |
title_full |
Triorganotin as a compound with potential reproductive toxicity in mammals |
title_fullStr |
Triorganotin as a compound with potential reproductive toxicity in mammals |
title_full_unstemmed |
Triorganotin as a compound with potential reproductive toxicity in mammals |
title_sort |
Triorganotin as a compound with potential reproductive toxicity in mammals |
author |
Delgado Filho,V.S. |
author_facet |
Delgado Filho,V.S. Lopes,P.F.I. Podratz,P.L. Graceli,J.B. |
author_role |
author |
author2 |
Lopes,P.F.I. Podratz,P.L. Graceli,J.B. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Delgado Filho,V.S. Lopes,P.F.I. Podratz,P.L. Graceli,J.B. |
dc.subject.por.fl_str_mv |
Tributyltin Triphenyltin Endocrine disruptor Aromatase Imposex Mammalian reproductive organs |
topic |
Tributyltin Triphenyltin Endocrine disruptor Aromatase Imposex Mammalian reproductive organs |
description |
Organotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive function. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900018 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900018 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X2011007500110 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.44 n.9 2011 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302940287336448 |