Anatomical connections of the periaqueductal gray: specific neural substrates for different kinds of fear
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000500002 |
Resumo: | The periaqueductal gray (PAG) has been traditionally considered to be an exit relay for defensive responses. Functional mapping of its subdivisions has advanced our knowledge of this structure, but synthesis remains difficult mainly because results from lesion and stimulation studies have not correlated perfectly. After using a strategy that combined both techniques and a reevaluation of the available literature on PAG function and connections, we propose here that freezing could be mediated by different PAG subdivisions depending on the presence of immediate danger or exposure to related signaling cues. These subdivisions are separate functional entities with distinct descending and ascending connections that are likely to play a role in different defensive responses. The existence of ascending connections also suggests that the PAG is not simply a final common path for defensive responses. For example, the possibility that indirect ascending connections to the cingulate cortex could play a role in the expression of freezing evoked by activation of the neural substrate of fear in the dorsal PAG has been considered. |
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Brazilian Journal of Medical and Biological Research |
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Anatomical connections of the periaqueductal gray: specific neural substrates for different kinds of fearPeriaqueductal grayDefense reactionFearEscapeFreezingPeriaqueductal gray columnsThe periaqueductal gray (PAG) has been traditionally considered to be an exit relay for defensive responses. Functional mapping of its subdivisions has advanced our knowledge of this structure, but synthesis remains difficult mainly because results from lesion and stimulation studies have not correlated perfectly. After using a strategy that combined both techniques and a reevaluation of the available literature on PAG function and connections, we propose here that freezing could be mediated by different PAG subdivisions depending on the presence of immediate danger or exposure to related signaling cues. These subdivisions are separate functional entities with distinct descending and ascending connections that are likely to play a role in different defensive responses. The existence of ascending connections also suggests that the PAG is not simply a final common path for defensive responses. For example, the possibility that indirect ascending connections to the cingulate cortex could play a role in the expression of freezing evoked by activation of the neural substrate of fear in the dorsal PAG has been considered.Associação Brasileira de Divulgação Científica2003-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000500002Brazilian Journal of Medical and Biological Research v.36 n.5 2003reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2003000500002info:eu-repo/semantics/openAccessVianna,D.M.L.Brandão,M.L.eng2003-04-22T00:00:00Zoai:scielo:S0100-879X2003000500002Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2003-04-22T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
Anatomical connections of the periaqueductal gray: specific neural substrates for different kinds of fear |
title |
Anatomical connections of the periaqueductal gray: specific neural substrates for different kinds of fear |
spellingShingle |
Anatomical connections of the periaqueductal gray: specific neural substrates for different kinds of fear Vianna,D.M.L. Periaqueductal gray Defense reaction Fear Escape Freezing Periaqueductal gray columns |
title_short |
Anatomical connections of the periaqueductal gray: specific neural substrates for different kinds of fear |
title_full |
Anatomical connections of the periaqueductal gray: specific neural substrates for different kinds of fear |
title_fullStr |
Anatomical connections of the periaqueductal gray: specific neural substrates for different kinds of fear |
title_full_unstemmed |
Anatomical connections of the periaqueductal gray: specific neural substrates for different kinds of fear |
title_sort |
Anatomical connections of the periaqueductal gray: specific neural substrates for different kinds of fear |
author |
Vianna,D.M.L. |
author_facet |
Vianna,D.M.L. Brandão,M.L. |
author_role |
author |
author2 |
Brandão,M.L. |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Vianna,D.M.L. Brandão,M.L. |
dc.subject.por.fl_str_mv |
Periaqueductal gray Defense reaction Fear Escape Freezing Periaqueductal gray columns |
topic |
Periaqueductal gray Defense reaction Fear Escape Freezing Periaqueductal gray columns |
description |
The periaqueductal gray (PAG) has been traditionally considered to be an exit relay for defensive responses. Functional mapping of its subdivisions has advanced our knowledge of this structure, but synthesis remains difficult mainly because results from lesion and stimulation studies have not correlated perfectly. After using a strategy that combined both techniques and a reevaluation of the available literature on PAG function and connections, we propose here that freezing could be mediated by different PAG subdivisions depending on the presence of immediate danger or exposure to related signaling cues. These subdivisions are separate functional entities with distinct descending and ascending connections that are likely to play a role in different defensive responses. The existence of ascending connections also suggests that the PAG is not simply a final common path for defensive responses. For example, the possibility that indirect ascending connections to the cingulate cortex could play a role in the expression of freezing evoked by activation of the neural substrate of fear in the dorsal PAG has been considered. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000500002 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000500002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X2003000500002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.36 n.5 2003 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302932150386688 |