Importance of immune response genes in hemophilia A
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista brasileira de hematologia e hemoterapia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000400280 |
Resumo: | Hemophilia A is a disease caused by a deficiency of coagulation factor VIII resulting from genetic inheritance linked to chromosome X. One treatment option is the administration of plasma or recombinant FVIII. However, some patients develop inhibitors or antibodies against this factor. Inhibitors are alloantibodies that bind to the epitope of factor VIII causing it to be recognized by the immune system as a foreign peptide. This is the most serious complication in hemophilia patients in respect to replacement therapy. Some studies have suggested that genetic factors influence the development of factor VIII inhibitors such as ethnicity, family history, mutations in the factor VIII gene and in genes of the immune system. The aim of this study was to conduct a literature review to assess the influence of genetic factors of immune response genes, especially genes of the major histocompatibility complex and cytokines, which may be related to the development of factor VIII inhibitors in hemophilia A patients. Understanding these risk factors will help to determine future differential treatment in the control and prevention of the development of inhibitors. |
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Importance of immune response genes in hemophilia AHemophilia ABlood coagulationFactor VIIIMajor histocompatibility complexCytokinesHuman Leukocyte AntigenHemophilia A is a disease caused by a deficiency of coagulation factor VIII resulting from genetic inheritance linked to chromosome X. One treatment option is the administration of plasma or recombinant FVIII. However, some patients develop inhibitors or antibodies against this factor. Inhibitors are alloantibodies that bind to the epitope of factor VIII causing it to be recognized by the immune system as a foreign peptide. This is the most serious complication in hemophilia patients in respect to replacement therapy. Some studies have suggested that genetic factors influence the development of factor VIII inhibitors such as ethnicity, family history, mutations in the factor VIII gene and in genes of the immune system. The aim of this study was to conduct a literature review to assess the influence of genetic factors of immune response genes, especially genes of the major histocompatibility complex and cytokines, which may be related to the development of factor VIII inhibitors in hemophilia A patients. Understanding these risk factors will help to determine future differential treatment in the control and prevention of the development of inhibitors.Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000400280Revista Brasileira de Hematologia e Hemoterapia v.35 n.4 2013reponame:Revista brasileira de hematologia e hemoterapia (Online)instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)instacron:ABHHTC10.5581/1516-8484.20130095info:eu-repo/semantics/openAccessAlencar,Josiane Bazzo deMacedo,Luciana ConciBarros,Morgana Ferreira deRodrigues,CamilaCadide,Renata CamposSell,Ana MariaVisentainer,Jeane Eliete Laguilaeng2013-10-10T00:00:00Zoai:scielo:S1516-84842013000400280Revistahttp://www.rbhh.org/pt/archivo/https://old.scielo.br/oai/scielo-oai.phpsbhh@terra.com.br||secretaria@rbhh.org1806-08701516-8484opendoar:2013-10-10T00:00Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC)false |
dc.title.none.fl_str_mv |
Importance of immune response genes in hemophilia A |
title |
Importance of immune response genes in hemophilia A |
spellingShingle |
Importance of immune response genes in hemophilia A Alencar,Josiane Bazzo de Hemophilia A Blood coagulation Factor VIII Major histocompatibility complex Cytokines Human Leukocyte Antigen |
title_short |
Importance of immune response genes in hemophilia A |
title_full |
Importance of immune response genes in hemophilia A |
title_fullStr |
Importance of immune response genes in hemophilia A |
title_full_unstemmed |
Importance of immune response genes in hemophilia A |
title_sort |
Importance of immune response genes in hemophilia A |
author |
Alencar,Josiane Bazzo de |
author_facet |
Alencar,Josiane Bazzo de Macedo,Luciana Conci Barros,Morgana Ferreira de Rodrigues,Camila Cadide,Renata Campos Sell,Ana Maria Visentainer,Jeane Eliete Laguila |
author_role |
author |
author2 |
Macedo,Luciana Conci Barros,Morgana Ferreira de Rodrigues,Camila Cadide,Renata Campos Sell,Ana Maria Visentainer,Jeane Eliete Laguila |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Alencar,Josiane Bazzo de Macedo,Luciana Conci Barros,Morgana Ferreira de Rodrigues,Camila Cadide,Renata Campos Sell,Ana Maria Visentainer,Jeane Eliete Laguila |
dc.subject.por.fl_str_mv |
Hemophilia A Blood coagulation Factor VIII Major histocompatibility complex Cytokines Human Leukocyte Antigen |
topic |
Hemophilia A Blood coagulation Factor VIII Major histocompatibility complex Cytokines Human Leukocyte Antigen |
description |
Hemophilia A is a disease caused by a deficiency of coagulation factor VIII resulting from genetic inheritance linked to chromosome X. One treatment option is the administration of plasma or recombinant FVIII. However, some patients develop inhibitors or antibodies against this factor. Inhibitors are alloantibodies that bind to the epitope of factor VIII causing it to be recognized by the immune system as a foreign peptide. This is the most serious complication in hemophilia patients in respect to replacement therapy. Some studies have suggested that genetic factors influence the development of factor VIII inhibitors such as ethnicity, family history, mutations in the factor VIII gene and in genes of the immune system. The aim of this study was to conduct a literature review to assess the influence of genetic factors of immune response genes, especially genes of the major histocompatibility complex and cytokines, which may be related to the development of factor VIII inhibitors in hemophilia A patients. Understanding these risk factors will help to determine future differential treatment in the control and prevention of the development of inhibitors. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000400280 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000400280 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.5581/1516-8484.20130095 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular |
publisher.none.fl_str_mv |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular |
dc.source.none.fl_str_mv |
Revista Brasileira de Hematologia e Hemoterapia v.35 n.4 2013 reponame:Revista brasileira de hematologia e hemoterapia (Online) instname:Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) instacron:ABHHTC |
instname_str |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) |
instacron_str |
ABHHTC |
institution |
ABHHTC |
reponame_str |
Revista brasileira de hematologia e hemoterapia (Online) |
collection |
Revista brasileira de hematologia e hemoterapia (Online) |
repository.name.fl_str_mv |
Revista brasileira de hematologia e hemoterapia (Online) - Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular (ABHHTC) |
repository.mail.fl_str_mv |
sbhh@terra.com.br||secretaria@rbhh.org |
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1754213111990059008 |