Magnetic Gelatin Microspheres for Targeted Release of Doxorubicin
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Materials research (São Carlos. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392021000600215 |
Resumo: | The aims of this work were to develop a magnetic carrier system consisting of microspheres made of gelatin for controlled release of doxorubicin and to investigate the ability of fructose, glucose, genipin and 1-ethyl-3(3-dimethylaminopropyl)carbodiimide (EDC) as crosslinking agents of gelatin microspheres. In addition, we also investigated the changes in the microspheres’ magnetic properties produced by using magnetite incorporated by three different methods and the doxorubicin release performance by using a constant, oscillating or no external magnetic field. The system obtained with fructose as crosslinker (low toxicity) was superparamagnetic, with high saturation magnetization and release profiles that could be controlled. Among the crosslinkers studied, genipin was the most efficient to reduce the solubility of the gelatin microspheres in water. When ferrous chloride was employed in magnetite synthesis, the Ms showed the highest values (61.6 emu/g), and its use in magnetic gelatin microspheres allowed the production of systems with high magnetization (29.6 emu/g). |
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Materials research (São Carlos. Online) |
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Magnetic Gelatin Microspheres for Targeted Release of DoxorubicinMagneticGelatinMicrospheresReleaseDoxorubicinsThe aims of this work were to develop a magnetic carrier system consisting of microspheres made of gelatin for controlled release of doxorubicin and to investigate the ability of fructose, glucose, genipin and 1-ethyl-3(3-dimethylaminopropyl)carbodiimide (EDC) as crosslinking agents of gelatin microspheres. In addition, we also investigated the changes in the microspheres’ magnetic properties produced by using magnetite incorporated by three different methods and the doxorubicin release performance by using a constant, oscillating or no external magnetic field. The system obtained with fructose as crosslinker (low toxicity) was superparamagnetic, with high saturation magnetization and release profiles that could be controlled. Among the crosslinkers studied, genipin was the most efficient to reduce the solubility of the gelatin microspheres in water. When ferrous chloride was employed in magnetite synthesis, the Ms showed the highest values (61.6 emu/g), and its use in magnetic gelatin microspheres allowed the production of systems with high magnetization (29.6 emu/g).ABM, ABC, ABPol2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392021000600215Materials Research v.24 n.6 2021reponame:Materials research (São Carlos. Online)instname:Universidade Federal de São Carlos (UFSCAR)instacron:ABM ABC ABPOL10.1590/1980-5373-mr-2021-0176info:eu-repo/semantics/openAccessSouza,Josefa Virginia da SilvaSilva,Manoel Ribeiro daCosta,Marcos Antonio da Silvaeng2021-09-29T00:00:00Zoai:scielo:S1516-14392021000600215Revistahttp://www.scielo.br/mrPUBhttps://old.scielo.br/oai/scielo-oai.phpdedz@power.ufscar.br1980-53731516-1439opendoar:2021-09-29T00:00Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR)false |
dc.title.none.fl_str_mv |
Magnetic Gelatin Microspheres for Targeted Release of Doxorubicin |
title |
Magnetic Gelatin Microspheres for Targeted Release of Doxorubicin |
spellingShingle |
Magnetic Gelatin Microspheres for Targeted Release of Doxorubicin Souza,Josefa Virginia da Silva Magnetic Gelatin Microspheres Release Doxorubicins |
title_short |
Magnetic Gelatin Microspheres for Targeted Release of Doxorubicin |
title_full |
Magnetic Gelatin Microspheres for Targeted Release of Doxorubicin |
title_fullStr |
Magnetic Gelatin Microspheres for Targeted Release of Doxorubicin |
title_full_unstemmed |
Magnetic Gelatin Microspheres for Targeted Release of Doxorubicin |
title_sort |
Magnetic Gelatin Microspheres for Targeted Release of Doxorubicin |
author |
Souza,Josefa Virginia da Silva |
author_facet |
Souza,Josefa Virginia da Silva Silva,Manoel Ribeiro da Costa,Marcos Antonio da Silva |
author_role |
author |
author2 |
Silva,Manoel Ribeiro da Costa,Marcos Antonio da Silva |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Souza,Josefa Virginia da Silva Silva,Manoel Ribeiro da Costa,Marcos Antonio da Silva |
dc.subject.por.fl_str_mv |
Magnetic Gelatin Microspheres Release Doxorubicins |
topic |
Magnetic Gelatin Microspheres Release Doxorubicins |
description |
The aims of this work were to develop a magnetic carrier system consisting of microspheres made of gelatin for controlled release of doxorubicin and to investigate the ability of fructose, glucose, genipin and 1-ethyl-3(3-dimethylaminopropyl)carbodiimide (EDC) as crosslinking agents of gelatin microspheres. In addition, we also investigated the changes in the microspheres’ magnetic properties produced by using magnetite incorporated by three different methods and the doxorubicin release performance by using a constant, oscillating or no external magnetic field. The system obtained with fructose as crosslinker (low toxicity) was superparamagnetic, with high saturation magnetization and release profiles that could be controlled. Among the crosslinkers studied, genipin was the most efficient to reduce the solubility of the gelatin microspheres in water. When ferrous chloride was employed in magnetite synthesis, the Ms showed the highest values (61.6 emu/g), and its use in magnetic gelatin microspheres allowed the production of systems with high magnetization (29.6 emu/g). |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392021000600215 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392021000600215 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1980-5373-mr-2021-0176 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
ABM, ABC, ABPol |
publisher.none.fl_str_mv |
ABM, ABC, ABPol |
dc.source.none.fl_str_mv |
Materials Research v.24 n.6 2021 reponame:Materials research (São Carlos. Online) instname:Universidade Federal de São Carlos (UFSCAR) instacron:ABM ABC ABPOL |
instname_str |
Universidade Federal de São Carlos (UFSCAR) |
instacron_str |
ABM ABC ABPOL |
institution |
ABM ABC ABPOL |
reponame_str |
Materials research (São Carlos. Online) |
collection |
Materials research (São Carlos. Online) |
repository.name.fl_str_mv |
Materials research (São Carlos. Online) - Universidade Federal de São Carlos (UFSCAR) |
repository.mail.fl_str_mv |
dedz@power.ufscar.br |
_version_ |
1754212679538442240 |