Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease

Detalhes bibliográficos
Autor(a) principal: Haddadi,Hossein
Data de Publicação: 2018
Outros Autores: Rajaei,Ziba, Alaei,Hojjatallah, Shahidani,Somayeh
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000200071
Resumo: ABSTRACT The present study investigated the effects of carvacrol on motor and memory deficits as well as hyperalgesia in the 6-OHDA-lesioned rat model of Parkinson's disease. The animals were subjected to unilateral microinjection of 6-OHDA into the medial forebrain bundle and treated with carvacrol (25, 50 and 100 mg/kg, ip) for six weeks after surgery. The 6-OHDA-lesioned rats showed contralateral rotations towards the lesion side, which was accompanied by learning and memory deficits in a passive avoidance test and a decrease in tail withdrawal latency in a tail flick test at the end of week 6. The results also showed that treatment with carvacrol at a dose of 25 mg/kg ameliorated memory deficits, with no effect on rotations and hyperalgesia in lesioned rats. In conclusion, carvacrol improves memory impairments in rats with Parkinson's disease; therefore, it may serve as an adjunct therapy for the alleviation of memory deficits in Parkinson's disease patients.
id ABNEURO-1_11f1aebee37e3199aa06ee6f26c6a1cb
oai_identifier_str oai:scielo:S0004-282X2018000200071
network_acronym_str ABNEURO-1
network_name_str Arquivos de neuro-psiquiatria (Online)
repository_id_str
spelling Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's diseaseCarvacrol6-hydroxydopaminememorymotor activityhyperalgesiaParkinson's diseaseABSTRACT The present study investigated the effects of carvacrol on motor and memory deficits as well as hyperalgesia in the 6-OHDA-lesioned rat model of Parkinson's disease. The animals were subjected to unilateral microinjection of 6-OHDA into the medial forebrain bundle and treated with carvacrol (25, 50 and 100 mg/kg, ip) for six weeks after surgery. The 6-OHDA-lesioned rats showed contralateral rotations towards the lesion side, which was accompanied by learning and memory deficits in a passive avoidance test and a decrease in tail withdrawal latency in a tail flick test at the end of week 6. The results also showed that treatment with carvacrol at a dose of 25 mg/kg ameliorated memory deficits, with no effect on rotations and hyperalgesia in lesioned rats. In conclusion, carvacrol improves memory impairments in rats with Parkinson's disease; therefore, it may serve as an adjunct therapy for the alleviation of memory deficits in Parkinson's disease patients.Academia Brasileira de Neurologia - ABNEURO2018-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000200071Arquivos de Neuro-Psiquiatria v.76 n.2 2018reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20170193info:eu-repo/semantics/openAccessHaddadi,HosseinRajaei,ZibaAlaei,HojjatallahShahidani,Somayeheng2018-02-23T00:00:00Zoai:scielo:S0004-282X2018000200071Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2018-02-23T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease
title Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease
spellingShingle Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease
Haddadi,Hossein
Carvacrol
6-hydroxydopamine
memory
motor activity
hyperalgesia
Parkinson's disease
title_short Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease
title_full Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease
title_fullStr Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease
title_full_unstemmed Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease
title_sort Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease
author Haddadi,Hossein
author_facet Haddadi,Hossein
Rajaei,Ziba
Alaei,Hojjatallah
Shahidani,Somayeh
author_role author
author2 Rajaei,Ziba
Alaei,Hojjatallah
Shahidani,Somayeh
author2_role author
author
author
dc.contributor.author.fl_str_mv Haddadi,Hossein
Rajaei,Ziba
Alaei,Hojjatallah
Shahidani,Somayeh
dc.subject.por.fl_str_mv Carvacrol
6-hydroxydopamine
memory
motor activity
hyperalgesia
Parkinson's disease
topic Carvacrol
6-hydroxydopamine
memory
motor activity
hyperalgesia
Parkinson's disease
description ABSTRACT The present study investigated the effects of carvacrol on motor and memory deficits as well as hyperalgesia in the 6-OHDA-lesioned rat model of Parkinson's disease. The animals were subjected to unilateral microinjection of 6-OHDA into the medial forebrain bundle and treated with carvacrol (25, 50 and 100 mg/kg, ip) for six weeks after surgery. The 6-OHDA-lesioned rats showed contralateral rotations towards the lesion side, which was accompanied by learning and memory deficits in a passive avoidance test and a decrease in tail withdrawal latency in a tail flick test at the end of week 6. The results also showed that treatment with carvacrol at a dose of 25 mg/kg ameliorated memory deficits, with no effect on rotations and hyperalgesia in lesioned rats. In conclusion, carvacrol improves memory impairments in rats with Parkinson's disease; therefore, it may serve as an adjunct therapy for the alleviation of memory deficits in Parkinson's disease patients.
publishDate 2018
dc.date.none.fl_str_mv 2018-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000200071
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2018000200071
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282x20170193
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.76 n.2 2018
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
_version_ 1754212783546695680

Registros relacionados