Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000600011 |
Resumo: | OBJECTIVE: To study the neurobehavioral, biochemical and histopathological consequences of permanent focal brain ischemia, and the putative neuroprotective action of ketoprofen. METHOD: One-hundred-and-three Wistar rats divided into groups A and B were respectively submitted to 48 hours and 15 days of ischemia. Each group was divided into 4 subgroups: ischemic not treated, ischemic treated, sham not treated, and sham treated. Ischemic animals had the left middle cerebral artery coagulated. Ketoprofen was administered to treated subgroups 15 minutes before arterial coagulation (manipulation in the sham group). RESULTS: Exploratory activity and defecation were reduced in all ischemic animals in the first postoperative days and constant histopathological changes were observed in each group. The total brain glutamate levels were higher in treated animals 48 hours after surgery. CONCLUSION: No clear parallelism among behavioral, biochemical and histopathological findings was observed. Ketoprofen demonstrated no neuroprotective effect on the behavioral or histopathological aspects of focal permanent brain ischemia. |
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Arquivos de neuro-psiquiatria (Online) |
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Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemiafocal brain ischemiaratopen fieldglutamatehistopathologyneuroprotectionketoprofenOBJECTIVE: To study the neurobehavioral, biochemical and histopathological consequences of permanent focal brain ischemia, and the putative neuroprotective action of ketoprofen. METHOD: One-hundred-and-three Wistar rats divided into groups A and B were respectively submitted to 48 hours and 15 days of ischemia. Each group was divided into 4 subgroups: ischemic not treated, ischemic treated, sham not treated, and sham treated. Ischemic animals had the left middle cerebral artery coagulated. Ketoprofen was administered to treated subgroups 15 minutes before arterial coagulation (manipulation in the sham group). RESULTS: Exploratory activity and defecation were reduced in all ischemic animals in the first postoperative days and constant histopathological changes were observed in each group. The total brain glutamate levels were higher in treated animals 48 hours after surgery. CONCLUSION: No clear parallelism among behavioral, biochemical and histopathological findings was observed. Ketoprofen demonstrated no neuroprotective effect on the behavioral or histopathological aspects of focal permanent brain ischemia.Academia Brasileira de Neurologia - ABNEURO2007-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000600011Arquivos de Neuro-Psiquiatria v.65 n.4a 2007reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2007000600011info:eu-repo/semantics/openAccessSilva,Manoel Nunes daColli,Benedicto OscarCoimbra,Norberto CysneCoutinho Netto,Joaquimeng2007-12-06T00:00:00Zoai:scielo:S0004-282X2007000600011Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2007-12-06T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia |
title |
Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia |
spellingShingle |
Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia Silva,Manoel Nunes da focal brain ischemia rat open field glutamate histopathology neuroprotection ketoprofen |
title_short |
Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia |
title_full |
Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia |
title_fullStr |
Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia |
title_full_unstemmed |
Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia |
title_sort |
Evaluation of the neuroprotective effect of ketoprofen on rats submitted to permanent focal brain ischemia |
author |
Silva,Manoel Nunes da |
author_facet |
Silva,Manoel Nunes da Colli,Benedicto Oscar Coimbra,Norberto Cysne Coutinho Netto,Joaquim |
author_role |
author |
author2 |
Colli,Benedicto Oscar Coimbra,Norberto Cysne Coutinho Netto,Joaquim |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Silva,Manoel Nunes da Colli,Benedicto Oscar Coimbra,Norberto Cysne Coutinho Netto,Joaquim |
dc.subject.por.fl_str_mv |
focal brain ischemia rat open field glutamate histopathology neuroprotection ketoprofen |
topic |
focal brain ischemia rat open field glutamate histopathology neuroprotection ketoprofen |
description |
OBJECTIVE: To study the neurobehavioral, biochemical and histopathological consequences of permanent focal brain ischemia, and the putative neuroprotective action of ketoprofen. METHOD: One-hundred-and-three Wistar rats divided into groups A and B were respectively submitted to 48 hours and 15 days of ischemia. Each group was divided into 4 subgroups: ischemic not treated, ischemic treated, sham not treated, and sham treated. Ischemic animals had the left middle cerebral artery coagulated. Ketoprofen was administered to treated subgroups 15 minutes before arterial coagulation (manipulation in the sham group). RESULTS: Exploratory activity and defecation were reduced in all ischemic animals in the first postoperative days and constant histopathological changes were observed in each group. The total brain glutamate levels were higher in treated animals 48 hours after surgery. CONCLUSION: No clear parallelism among behavioral, biochemical and histopathological findings was observed. Ketoprofen demonstrated no neuroprotective effect on the behavioral or histopathological aspects of focal permanent brain ischemia. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000600011 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2007000600011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2007000600011 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.65 n.4a 2007 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212762720927744 |