Mast cell subsets and neuropeptides in leprosy reactions

Detalhes bibliográficos
Autor(a) principal: Antunes,Sérgio Luiz Gomes
Data de Publicação: 2003
Outros Autores: Liang,Yong, Neri,José Augusto da Costa, Sarno,Euzenir Nunes, Haak-Frendscho,Mary, Johansson,Olle
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000200010
Resumo: The immunohistochemical identification of neuropeptides (calcitonin gene-related peptide, vasoactive intestinal polypeptide, substance P, alpha-melanocyte stimulating hormone and gamma-melanocyte stimulating hormone) quantification of mast cells and their subsets (tryptase/chymase-immunoreactive mast cells = TCMC and tryptase-immunoreactive mast cells = TMC) were determined in biopsies of six patients with leprosy reactions (three patients with type I reaction and three with type II). Biopsies were compared with those taken from the same body site in the remission stage of the same patient. We found a relative increase of TMC in the inflammatory infiltrate of the reactional biopsies compared to the post-reactional biopsy. Also, the total number of mast cells and the TMC/TCMC ratio in the inflammatory infiltrate was significantly higher than in the intervening dermis of the biopsies of both periods. No significant difference was found regarding neuroptide expression in the reactional and post-reactional biopsies. The relative increase of TMC in the reactional infiltrates could implicate this mast cell subset in the reported increase of the immune response in leprosy reactions.
id ABNEURO-1_76975ac2cf3637c140a775d191342607
oai_identifier_str oai:scielo:S0004-282X2003000200010
network_acronym_str ABNEURO-1
network_name_str Arquivos de neuro-psiquiatria (Online)
repository_id_str
spelling Mast cell subsets and neuropeptides in leprosy reactionsleprosyneuropeptidesmast cellstryptasechymaseThe immunohistochemical identification of neuropeptides (calcitonin gene-related peptide, vasoactive intestinal polypeptide, substance P, alpha-melanocyte stimulating hormone and gamma-melanocyte stimulating hormone) quantification of mast cells and their subsets (tryptase/chymase-immunoreactive mast cells = TCMC and tryptase-immunoreactive mast cells = TMC) were determined in biopsies of six patients with leprosy reactions (three patients with type I reaction and three with type II). Biopsies were compared with those taken from the same body site in the remission stage of the same patient. We found a relative increase of TMC in the inflammatory infiltrate of the reactional biopsies compared to the post-reactional biopsy. Also, the total number of mast cells and the TMC/TCMC ratio in the inflammatory infiltrate was significantly higher than in the intervening dermis of the biopsies of both periods. No significant difference was found regarding neuroptide expression in the reactional and post-reactional biopsies. The relative increase of TMC in the reactional infiltrates could implicate this mast cell subset in the reported increase of the immune response in leprosy reactions.Academia Brasileira de Neurologia - ABNEURO2003-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000200010Arquivos de Neuro-Psiquiatria v.61 n.2A 2003reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2003000200010info:eu-repo/semantics/openAccessAntunes,Sérgio Luiz GomesLiang,YongNeri,José Augusto da CostaSarno,Euzenir NunesHaak-Frendscho,MaryJohansson,Olleeng2003-06-09T00:00:00Zoai:scielo:S0004-282X2003000200010Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2003-06-09T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Mast cell subsets and neuropeptides in leprosy reactions
title Mast cell subsets and neuropeptides in leprosy reactions
spellingShingle Mast cell subsets and neuropeptides in leprosy reactions
Antunes,Sérgio Luiz Gomes
leprosy
neuropeptides
mast cells
tryptase
chymase
title_short Mast cell subsets and neuropeptides in leprosy reactions
title_full Mast cell subsets and neuropeptides in leprosy reactions
title_fullStr Mast cell subsets and neuropeptides in leprosy reactions
title_full_unstemmed Mast cell subsets and neuropeptides in leprosy reactions
title_sort Mast cell subsets and neuropeptides in leprosy reactions
author Antunes,Sérgio Luiz Gomes
author_facet Antunes,Sérgio Luiz Gomes
Liang,Yong
Neri,José Augusto da Costa
Sarno,Euzenir Nunes
Haak-Frendscho,Mary
Johansson,Olle
author_role author
author2 Liang,Yong
Neri,José Augusto da Costa
Sarno,Euzenir Nunes
Haak-Frendscho,Mary
Johansson,Olle
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Antunes,Sérgio Luiz Gomes
Liang,Yong
Neri,José Augusto da Costa
Sarno,Euzenir Nunes
Haak-Frendscho,Mary
Johansson,Olle
dc.subject.por.fl_str_mv leprosy
neuropeptides
mast cells
tryptase
chymase
topic leprosy
neuropeptides
mast cells
tryptase
chymase
description The immunohistochemical identification of neuropeptides (calcitonin gene-related peptide, vasoactive intestinal polypeptide, substance P, alpha-melanocyte stimulating hormone and gamma-melanocyte stimulating hormone) quantification of mast cells and their subsets (tryptase/chymase-immunoreactive mast cells = TCMC and tryptase-immunoreactive mast cells = TMC) were determined in biopsies of six patients with leprosy reactions (three patients with type I reaction and three with type II). Biopsies were compared with those taken from the same body site in the remission stage of the same patient. We found a relative increase of TMC in the inflammatory infiltrate of the reactional biopsies compared to the post-reactional biopsy. Also, the total number of mast cells and the TMC/TCMC ratio in the inflammatory infiltrate was significantly higher than in the intervening dermis of the biopsies of both periods. No significant difference was found regarding neuroptide expression in the reactional and post-reactional biopsies. The relative increase of TMC in the reactional infiltrates could implicate this mast cell subset in the reported increase of the immune response in leprosy reactions.
publishDate 2003
dc.date.none.fl_str_mv 2003-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000200010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000200010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-282X2003000200010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.61 n.2A 2003
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
_version_ 1754212755171180544