Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000600462 |
Resumo: | ABSTRACT Purpose of the study was evaluate the possible antinociceptive effect of botulinum neurotoxin type-A (BoNT/A) in an experimental model of trigeminal neuralgia. Method Neuropathic pain was induced by surgical constriction of the infraorbital nerve in rats. A control group underwent a sham procedure consisting of surgical exposure of the nerve. Subgroups of each group received either BoNT/A or isotonic saline solution. The clinical response was assessed with the -20°C test. Animals that underwent nerve constriction developed sensitization; the sham group did not. Results The sensitization was reversed by BoNT/A treatment evident 24 hours following application. Pronociceptive effect was observed in the sham group following BoNT/A. Conclusion BoNT/A has an antinociceptive effect in sensitized animals and a pronociceptive effect in non-sensitized animals. |
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Arquivos de neuro-psiquiatria (Online) |
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Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effectanalgesicsbotulinum toxinsfacial paintrigeminal neuralgiaABSTRACT Purpose of the study was evaluate the possible antinociceptive effect of botulinum neurotoxin type-A (BoNT/A) in an experimental model of trigeminal neuralgia. Method Neuropathic pain was induced by surgical constriction of the infraorbital nerve in rats. A control group underwent a sham procedure consisting of surgical exposure of the nerve. Subgroups of each group received either BoNT/A or isotonic saline solution. The clinical response was assessed with the -20°C test. Animals that underwent nerve constriction developed sensitization; the sham group did not. Results The sensitization was reversed by BoNT/A treatment evident 24 hours following application. Pronociceptive effect was observed in the sham group following BoNT/A. Conclusion BoNT/A has an antinociceptive effect in sensitized animals and a pronociceptive effect in non-sensitized animals.Academia Brasileira de Neurologia - ABNEURO2016-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000600462Arquivos de Neuro-Psiquiatria v.74 n.6 2016reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20160067info:eu-repo/semantics/openAccessPiovesan,Elcio JOshinsky,MichaelSilberstein,StephenKowacs,Pedro AndreNovak,Edison MatosWerneck,Lineu Cesareng2017-01-11T00:00:00Zoai:scielo:S0004-282X2016000600462Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2017-01-11T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect |
title |
Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect |
spellingShingle |
Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect Piovesan,Elcio J analgesics botulinum toxins facial pain trigeminal neuralgia |
title_short |
Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect |
title_full |
Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect |
title_fullStr |
Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect |
title_full_unstemmed |
Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect |
title_sort |
Botulinum neurotoxin type-A when utilized in animals with trigeminal sensitization induced a antinociceptive effect |
author |
Piovesan,Elcio J |
author_facet |
Piovesan,Elcio J Oshinsky,Michael Silberstein,Stephen Kowacs,Pedro Andre Novak,Edison Matos Werneck,Lineu Cesar |
author_role |
author |
author2 |
Oshinsky,Michael Silberstein,Stephen Kowacs,Pedro Andre Novak,Edison Matos Werneck,Lineu Cesar |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Piovesan,Elcio J Oshinsky,Michael Silberstein,Stephen Kowacs,Pedro Andre Novak,Edison Matos Werneck,Lineu Cesar |
dc.subject.por.fl_str_mv |
analgesics botulinum toxins facial pain trigeminal neuralgia |
topic |
analgesics botulinum toxins facial pain trigeminal neuralgia |
description |
ABSTRACT Purpose of the study was evaluate the possible antinociceptive effect of botulinum neurotoxin type-A (BoNT/A) in an experimental model of trigeminal neuralgia. Method Neuropathic pain was induced by surgical constriction of the infraorbital nerve in rats. A control group underwent a sham procedure consisting of surgical exposure of the nerve. Subgroups of each group received either BoNT/A or isotonic saline solution. The clinical response was assessed with the -20°C test. Animals that underwent nerve constriction developed sensitization; the sham group did not. Results The sensitization was reversed by BoNT/A treatment evident 24 hours following application. Pronociceptive effect was observed in the sham group following BoNT/A. Conclusion BoNT/A has an antinociceptive effect in sensitized animals and a pronociceptive effect in non-sensitized animals. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000600462 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016000600462 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x20160067 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.74 n.6 2016 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212780326518784 |