Botulinum toxin in pain management of trigeminal neuralgia: literature review

• Autor(a) principal: Romero,João Gabriel de Azevedo José
• Data de Publicação: 2020
• Outros Autores: Pedras,Roberto Brígido de Nazareth, Almeida-Leite,Camila Megale
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: BrJP (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2595-31922020000400366
• topic: Botulinum toxins; Facial pain; Trigeminal neuralgia

ABSTRACT BACKGROUND AND OBJECTIVES: Botulinum neurotoxin type A has been an interesting therapeutic complement to the conventional treatment of trigeminal neuralgia, especially in patients without satisfactory response to pharmacotherapy and/or surgical procedures. A detailed and comprehensive literature review its important for the description of the available evidence, allowing for a critical view on the topic. Therefore, this study's objective was to describe the scientific evidence on the use of botulinum toxin type A in the trigeminal neuralgia treatment. CONTENTS: Pubmed and Scielo databases were searched using the descriptors: "trigeminal neuralgia and botulinum toxin". Inclusion criteria were human studies (open-label, double-blind, randomized, and placebo-controlled trials) and reviews of the use of botulinum toxin type A in trigeminal neuralgia treatment, published in English, Spanish or Portuguese from January 2008 to March 2020. Twenty-one articles met the inclusion criteria. Overall, studies demonstrated that botulinum toxin type A significantly reduced pain intensity and paroxysmal episodes, as well as improved quality of life. CONCLUSION: Use of botulinum toxin type A in treatment of refractory trigeminal neuralgia shows promising results, but further studies are needed to increase the knowledge and consolidation of this therapeutic alternative.