HLA-alleles class I and II associated with genetic susceptibility to neuromyelitis optica in Brazilian patients
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019000400239 |
Resumo: | ABSTRACT Objective: To study the genetic susceptibility to neuromyelitis optica (NMO) as well as the relationship between HLA genotypes and susceptibility to the disease in the southern Brazilian population. Methods: We analyzed patients with NMO, who met criteria for Wingerchuk's diagnosis of NMO, with detected serum anti-AQP4-IgG antibody. The HLA genotyping was performed by high-resolution techniques (Sanger sequencing) in patients and controls. The HLA genotypes were statistically compared with a paired control population. Results: The HLA genotyping revealed the diversity of the southern Brazilian population whose HLA profile resembled European and Asian populations. Some alleles had statistical correlations with a positive association (increased susceptibility) with NMO, particularly the HLA-DRB1*04:05 and *16:02. Conclusions: In our study, the HLA genotype was different to that previously reported for other Brazilian populations. Although our study had a small cohort, HLA genotypes were associated with increased susceptibility to NMO for HLA-DRB1*04:05 and *16:02. The alleles of HLA class I HLA-A*02:08 and *30:09, HLA-B*08:04 and *35:04 showed an association before the Bonferroni correction. |
id |
ABNEURO-1_a91bf8cdc7f3d567566861cfb4cff942 |
---|---|
oai_identifier_str |
oai:scielo:S0004-282X2019000400239 |
network_acronym_str |
ABNEURO-1 |
network_name_str |
Arquivos de neuro-psiquiatria (Online) |
repository_id_str |
|
spelling |
HLA-alleles class I and II associated with genetic susceptibility to neuromyelitis optica in Brazilian patientsGenetic predisposition to diseaseHLA antigensimmunogeneticsmajor histocompatibility complexneuromyelitis opticaABSTRACT Objective: To study the genetic susceptibility to neuromyelitis optica (NMO) as well as the relationship between HLA genotypes and susceptibility to the disease in the southern Brazilian population. Methods: We analyzed patients with NMO, who met criteria for Wingerchuk's diagnosis of NMO, with detected serum anti-AQP4-IgG antibody. The HLA genotyping was performed by high-resolution techniques (Sanger sequencing) in patients and controls. The HLA genotypes were statistically compared with a paired control population. Results: The HLA genotyping revealed the diversity of the southern Brazilian population whose HLA profile resembled European and Asian populations. Some alleles had statistical correlations with a positive association (increased susceptibility) with NMO, particularly the HLA-DRB1*04:05 and *16:02. Conclusions: In our study, the HLA genotype was different to that previously reported for other Brazilian populations. Although our study had a small cohort, HLA genotypes were associated with increased susceptibility to NMO for HLA-DRB1*04:05 and *16:02. The alleles of HLA class I HLA-A*02:08 and *30:09, HLA-B*08:04 and *35:04 showed an association before the Bonferroni correction.Academia Brasileira de Neurologia - ABNEURO2019-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019000400239Arquivos de Neuro-Psiquiatria v.77 n.4 2019reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282x20190031info:eu-repo/semantics/openAccessKay,Cláudia Suemi KamoiScola,Rosana HerminiaArndt,Raquel CristinaLorenzoni,Paulo JoséWerneck,Lineu Cesareng2019-05-08T00:00:00Zoai:scielo:S0004-282X2019000400239Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2019-05-08T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
HLA-alleles class I and II associated with genetic susceptibility to neuromyelitis optica in Brazilian patients |
title |
HLA-alleles class I and II associated with genetic susceptibility to neuromyelitis optica in Brazilian patients |
spellingShingle |
HLA-alleles class I and II associated with genetic susceptibility to neuromyelitis optica in Brazilian patients Kay,Cláudia Suemi Kamoi Genetic predisposition to disease HLA antigens immunogenetics major histocompatibility complex neuromyelitis optica |
title_short |
HLA-alleles class I and II associated with genetic susceptibility to neuromyelitis optica in Brazilian patients |
title_full |
HLA-alleles class I and II associated with genetic susceptibility to neuromyelitis optica in Brazilian patients |
title_fullStr |
HLA-alleles class I and II associated with genetic susceptibility to neuromyelitis optica in Brazilian patients |
title_full_unstemmed |
HLA-alleles class I and II associated with genetic susceptibility to neuromyelitis optica in Brazilian patients |
title_sort |
HLA-alleles class I and II associated with genetic susceptibility to neuromyelitis optica in Brazilian patients |
author |
Kay,Cláudia Suemi Kamoi |
author_facet |
Kay,Cláudia Suemi Kamoi Scola,Rosana Herminia Arndt,Raquel Cristina Lorenzoni,Paulo José Werneck,Lineu Cesar |
author_role |
author |
author2 |
Scola,Rosana Herminia Arndt,Raquel Cristina Lorenzoni,Paulo José Werneck,Lineu Cesar |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Kay,Cláudia Suemi Kamoi Scola,Rosana Herminia Arndt,Raquel Cristina Lorenzoni,Paulo José Werneck,Lineu Cesar |
dc.subject.por.fl_str_mv |
Genetic predisposition to disease HLA antigens immunogenetics major histocompatibility complex neuromyelitis optica |
topic |
Genetic predisposition to disease HLA antigens immunogenetics major histocompatibility complex neuromyelitis optica |
description |
ABSTRACT Objective: To study the genetic susceptibility to neuromyelitis optica (NMO) as well as the relationship between HLA genotypes and susceptibility to the disease in the southern Brazilian population. Methods: We analyzed patients with NMO, who met criteria for Wingerchuk's diagnosis of NMO, with detected serum anti-AQP4-IgG antibody. The HLA genotyping was performed by high-resolution techniques (Sanger sequencing) in patients and controls. The HLA genotypes were statistically compared with a paired control population. Results: The HLA genotyping revealed the diversity of the southern Brazilian population whose HLA profile resembled European and Asian populations. Some alleles had statistical correlations with a positive association (increased susceptibility) with NMO, particularly the HLA-DRB1*04:05 and *16:02. Conclusions: In our study, the HLA genotype was different to that previously reported for other Brazilian populations. Although our study had a small cohort, HLA genotypes were associated with increased susceptibility to NMO for HLA-DRB1*04:05 and *16:02. The alleles of HLA class I HLA-A*02:08 and *30:09, HLA-B*08:04 and *35:04 showed an association before the Bonferroni correction. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019000400239 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019000400239 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282x20190031 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.77 n.4 2019 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
_version_ |
1754212784884678656 |