Cerebrospinal fluid approach on neuro-oncology

Detalhes bibliográficos
Autor(a) principal: Gomes,Helio Rodrigues
Data de Publicação: 2013
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos de neuro-psiquiatria (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001000677
Resumo: Central nervous system (CNS) involvement is a major complication of haematological and solid tumors with an incidence that ranges from 10% in solid malignances up to 25% in specific leukaemia or lymphoma subtypes. Cerebrospinal fluid (CSF) patterns are unspecific. Though CSF cytology has a high specificity (up to 95%), its sensitivity is generally less than 50% and no diagnostic gold standard marker is available, yet. New technologies such as flow cytometry, molecular genetics and newer biomarkers may improve diagnostic sensitivity and specificity, leading to the CNS involvement diagnosis, and consequently, to an effective prophylaxis and successful treatment.
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spelling Cerebrospinal fluid approach on neuro-oncologycerebrospinal fluidbiomarkersleptomeningeal metastasisneoplastic meningitisliquido cefalorraquianobiomarcadoresmetastase leptomeningeameningite neoplasicaCentral nervous system (CNS) involvement is a major complication of haematological and solid tumors with an incidence that ranges from 10% in solid malignances up to 25% in specific leukaemia or lymphoma subtypes. Cerebrospinal fluid (CSF) patterns are unspecific. Though CSF cytology has a high specificity (up to 95%), its sensitivity is generally less than 50% and no diagnostic gold standard marker is available, yet. New technologies such as flow cytometry, molecular genetics and newer biomarkers may improve diagnostic sensitivity and specificity, leading to the CNS involvement diagnosis, and consequently, to an effective prophylaxis and successful treatment.Academia Brasileira de Neurologia - ABNEURO2013-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001000677Arquivos de Neuro-Psiquiatria v.71 n.9B 2013reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20130149info:eu-repo/semantics/openAccessGomes,Helio Rodrigueseng2013-10-10T00:00:00Zoai:scielo:S0004-282X2013001000677Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2013-10-10T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse
dc.title.none.fl_str_mv Cerebrospinal fluid approach on neuro-oncology
title Cerebrospinal fluid approach on neuro-oncology
spellingShingle Cerebrospinal fluid approach on neuro-oncology
Gomes,Helio Rodrigues
cerebrospinal fluid
biomarkers
leptomeningeal metastasis
neoplastic meningitis
liquido cefalorraquiano
biomarcadores
metastase leptomeningea
meningite neoplasica
title_short Cerebrospinal fluid approach on neuro-oncology
title_full Cerebrospinal fluid approach on neuro-oncology
title_fullStr Cerebrospinal fluid approach on neuro-oncology
title_full_unstemmed Cerebrospinal fluid approach on neuro-oncology
title_sort Cerebrospinal fluid approach on neuro-oncology
author Gomes,Helio Rodrigues
author_facet Gomes,Helio Rodrigues
author_role author
dc.contributor.author.fl_str_mv Gomes,Helio Rodrigues
dc.subject.por.fl_str_mv cerebrospinal fluid
biomarkers
leptomeningeal metastasis
neoplastic meningitis
liquido cefalorraquiano
biomarcadores
metastase leptomeningea
meningite neoplasica
topic cerebrospinal fluid
biomarkers
leptomeningeal metastasis
neoplastic meningitis
liquido cefalorraquiano
biomarcadores
metastase leptomeningea
meningite neoplasica
description Central nervous system (CNS) involvement is a major complication of haematological and solid tumors with an incidence that ranges from 10% in solid malignances up to 25% in specific leukaemia or lymphoma subtypes. Cerebrospinal fluid (CSF) patterns are unspecific. Though CSF cytology has a high specificity (up to 95%), its sensitivity is generally less than 50% and no diagnostic gold standard marker is available, yet. New technologies such as flow cytometry, molecular genetics and newer biomarkers may improve diagnostic sensitivity and specificity, leading to the CNS involvement diagnosis, and consequently, to an effective prophylaxis and successful treatment.
publishDate 2013
dc.date.none.fl_str_mv 2013-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001000677
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001000677
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-282X20130149
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv Arquivos de Neuro-Psiquiatria v.71 n.9B 2013
reponame:Arquivos de neuro-psiquiatria (Online)
instname:Academia Brasileira de Neurologia
instacron:ABNEURO
instname_str Academia Brasileira de Neurologia
instacron_str ABNEURO
institution ABNEURO
reponame_str Arquivos de neuro-psiquiatria (Online)
collection Arquivos de neuro-psiquiatria (Online)
repository.name.fl_str_mv Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia
repository.mail.fl_str_mv ||revista.arquivos@abneuro.org
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