Cerebrospinal fluid approach on neuro-oncology
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001000677 |
Resumo: | Central nervous system (CNS) involvement is a major complication of haematological and solid tumors with an incidence that ranges from 10% in solid malignances up to 25% in specific leukaemia or lymphoma subtypes. Cerebrospinal fluid (CSF) patterns are unspecific. Though CSF cytology has a high specificity (up to 95%), its sensitivity is generally less than 50% and no diagnostic gold standard marker is available, yet. New technologies such as flow cytometry, molecular genetics and newer biomarkers may improve diagnostic sensitivity and specificity, leading to the CNS involvement diagnosis, and consequently, to an effective prophylaxis and successful treatment. |
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Cerebrospinal fluid approach on neuro-oncologycerebrospinal fluidbiomarkersleptomeningeal metastasisneoplastic meningitisliquido cefalorraquianobiomarcadoresmetastase leptomeningeameningite neoplasicaCentral nervous system (CNS) involvement is a major complication of haematological and solid tumors with an incidence that ranges from 10% in solid malignances up to 25% in specific leukaemia or lymphoma subtypes. Cerebrospinal fluid (CSF) patterns are unspecific. Though CSF cytology has a high specificity (up to 95%), its sensitivity is generally less than 50% and no diagnostic gold standard marker is available, yet. New technologies such as flow cytometry, molecular genetics and newer biomarkers may improve diagnostic sensitivity and specificity, leading to the CNS involvement diagnosis, and consequently, to an effective prophylaxis and successful treatment.Academia Brasileira de Neurologia - ABNEURO2013-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001000677Arquivos de Neuro-Psiquiatria v.71 n.9B 2013reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/0004-282X20130149info:eu-repo/semantics/openAccessGomes,Helio Rodrigueseng2013-10-10T00:00:00Zoai:scielo:S0004-282X2013001000677Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2013-10-10T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Cerebrospinal fluid approach on neuro-oncology |
title |
Cerebrospinal fluid approach on neuro-oncology |
spellingShingle |
Cerebrospinal fluid approach on neuro-oncology Gomes,Helio Rodrigues cerebrospinal fluid biomarkers leptomeningeal metastasis neoplastic meningitis liquido cefalorraquiano biomarcadores metastase leptomeningea meningite neoplasica |
title_short |
Cerebrospinal fluid approach on neuro-oncology |
title_full |
Cerebrospinal fluid approach on neuro-oncology |
title_fullStr |
Cerebrospinal fluid approach on neuro-oncology |
title_full_unstemmed |
Cerebrospinal fluid approach on neuro-oncology |
title_sort |
Cerebrospinal fluid approach on neuro-oncology |
author |
Gomes,Helio Rodrigues |
author_facet |
Gomes,Helio Rodrigues |
author_role |
author |
dc.contributor.author.fl_str_mv |
Gomes,Helio Rodrigues |
dc.subject.por.fl_str_mv |
cerebrospinal fluid biomarkers leptomeningeal metastasis neoplastic meningitis liquido cefalorraquiano biomarcadores metastase leptomeningea meningite neoplasica |
topic |
cerebrospinal fluid biomarkers leptomeningeal metastasis neoplastic meningitis liquido cefalorraquiano biomarcadores metastase leptomeningea meningite neoplasica |
description |
Central nervous system (CNS) involvement is a major complication of haematological and solid tumors with an incidence that ranges from 10% in solid malignances up to 25% in specific leukaemia or lymphoma subtypes. Cerebrospinal fluid (CSF) patterns are unspecific. Though CSF cytology has a high specificity (up to 95%), its sensitivity is generally less than 50% and no diagnostic gold standard marker is available, yet. New technologies such as flow cytometry, molecular genetics and newer biomarkers may improve diagnostic sensitivity and specificity, leading to the CNS involvement diagnosis, and consequently, to an effective prophylaxis and successful treatment. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001000677 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2013001000677 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0004-282X20130149 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.71 n.9B 2013 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212775324811264 |