Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos de neuro-psiquiatria (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000400009 |
Resumo: | OBJECTIVE: To evaluate the impact of autologous hematopoetic stem cell transplantation (autoHSCT) in the health related quality of life (HRQL) in patients with multiple sclerosis. METHOD: The sample consisted of 34 patients, over 18 years old, treated at a University Hospital in the state of São Paulo, Brazil. For data collection MOS SF-36 and EDSS scales were applied at three time points: admission of the patient, hospital discharge and 1 year posttransplantation. RESULTS: 27 patients (79%) showed stabilization or neurological improvement 1 year posttransplantation. At this time point, there was statistically significant improvement in all domains of the HRQoL. When EDSS scores were correlated with the domains of the MOS SF-36 scale, statistically significant correlations were found with physical functioning at the three time points analysed. CONCLUSION: In spite of the high risk of complications of the procedure, the HSCT had positive impact in the health related quality of life. |
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Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosisquality of lifemultiple sclerosisbone marrow transplantationOBJECTIVE: To evaluate the impact of autologous hematopoetic stem cell transplantation (autoHSCT) in the health related quality of life (HRQL) in patients with multiple sclerosis. METHOD: The sample consisted of 34 patients, over 18 years old, treated at a University Hospital in the state of São Paulo, Brazil. For data collection MOS SF-36 and EDSS scales were applied at three time points: admission of the patient, hospital discharge and 1 year posttransplantation. RESULTS: 27 patients (79%) showed stabilization or neurological improvement 1 year posttransplantation. At this time point, there was statistically significant improvement in all domains of the HRQoL. When EDSS scores were correlated with the domains of the MOS SF-36 scale, statistically significant correlations were found with physical functioning at the three time points analysed. CONCLUSION: In spite of the high risk of complications of the procedure, the HSCT had positive impact in the health related quality of life.Academia Brasileira de Neurologia - ABNEURO2010-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000400009Arquivos de Neuro-Psiquiatria v.68 n.4 2010reponame:Arquivos de neuro-psiquiatria (Online)instname:Academia Brasileira de Neurologiainstacron:ABNEURO10.1590/S0004-282X2010000400009info:eu-repo/semantics/openAccessGuimarães,Fabio Augusto BronziOliveira-Cardoso,Érika Arantes deMastropietro,Ana PaulaVoltarelli,Júlio CésarSantos,Manoel Antônio doseng2010-08-11T00:00:00Zoai:scielo:S0004-282X2010000400009Revistahttp://www.scielo.br/anphttps://old.scielo.br/oai/scielo-oai.php||revista.arquivos@abneuro.org1678-42270004-282Xopendoar:2010-08-11T00:00Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologiafalse |
dc.title.none.fl_str_mv |
Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis |
title |
Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis |
spellingShingle |
Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis Guimarães,Fabio Augusto Bronzi quality of life multiple sclerosis bone marrow transplantation |
title_short |
Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis |
title_full |
Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis |
title_fullStr |
Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis |
title_full_unstemmed |
Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis |
title_sort |
Impact of autologous hematopoetic stem cell transplantation on the quality of life of patients with multiple sclerosis |
author |
Guimarães,Fabio Augusto Bronzi |
author_facet |
Guimarães,Fabio Augusto Bronzi Oliveira-Cardoso,Érika Arantes de Mastropietro,Ana Paula Voltarelli,Júlio César Santos,Manoel Antônio dos |
author_role |
author |
author2 |
Oliveira-Cardoso,Érika Arantes de Mastropietro,Ana Paula Voltarelli,Júlio César Santos,Manoel Antônio dos |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Guimarães,Fabio Augusto Bronzi Oliveira-Cardoso,Érika Arantes de Mastropietro,Ana Paula Voltarelli,Júlio César Santos,Manoel Antônio dos |
dc.subject.por.fl_str_mv |
quality of life multiple sclerosis bone marrow transplantation |
topic |
quality of life multiple sclerosis bone marrow transplantation |
description |
OBJECTIVE: To evaluate the impact of autologous hematopoetic stem cell transplantation (autoHSCT) in the health related quality of life (HRQL) in patients with multiple sclerosis. METHOD: The sample consisted of 34 patients, over 18 years old, treated at a University Hospital in the state of São Paulo, Brazil. For data collection MOS SF-36 and EDSS scales were applied at three time points: admission of the patient, hospital discharge and 1 year posttransplantation. RESULTS: 27 patients (79%) showed stabilization or neurological improvement 1 year posttransplantation. At this time point, there was statistically significant improvement in all domains of the HRQoL. When EDSS scores were correlated with the domains of the MOS SF-36 scale, statistically significant correlations were found with physical functioning at the three time points analysed. CONCLUSION: In spite of the high risk of complications of the procedure, the HSCT had positive impact in the health related quality of life. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000400009 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2010000400009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-282X2010000400009 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria v.68 n.4 2010 reponame:Arquivos de neuro-psiquiatria (Online) instname:Academia Brasileira de Neurologia instacron:ABNEURO |
instname_str |
Academia Brasileira de Neurologia |
instacron_str |
ABNEURO |
institution |
ABNEURO |
reponame_str |
Arquivos de neuro-psiquiatria (Online) |
collection |
Arquivos de neuro-psiquiatria (Online) |
repository.name.fl_str_mv |
Arquivos de neuro-psiquiatria (Online) - Academia Brasileira de Neurologia |
repository.mail.fl_str_mv |
||revista.arquivos@abneuro.org |
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1754212768906477568 |