Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms

Detalhes bibliográficos
Autor(a) principal: Silva, Rafael Carriello da
Data de Publicação: 2021
Outros Autores: Araujo, Geisoellen Felicio, Pascoal, Vinicius D'avila Bitencourt, Camargo, Gabriela Alessandra Cruz Galhardo, Robbs, Bruno Kaufmann
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Brasileira de Odontologia
Texto Completo: https://revista.aborj.org.br/index.php/rbo/article/view/1930
Resumo: Objective: to describe different in vivo and in vitro experimental models and summarize evidence that proposes molecular mechanisms or demonstrate a cause and effect correlation between periodontal disease (PD) and oral squamous cell carcinoma development. Material and Methods: a Literature search of various electronic databases (Medline, SCOPUS, Web of Science) using appropriate keywords (e.g., periodontal disease, periodontitis, squamous cell carcinoma, oral cancer, transformation, carcinogenesis, mouth neoplasms, and carcinoma) was performed. Then, a comprehensive literature review of the current understanding of this link was elaborated. Results: the experimental data suggest that PD induces initiation, promotion, and oral squamous cell carcinoma progression. Periodontal disease models here revised demonstrate a direct relation to carcinogenesis and propose several possible molecular mechanisms of action, such as via activation of Toll-like receptors (TLRs), activation of transcription 3 activator (STAT3) and Notch1 pathways and increased interleukin-6 (IL-6), TNF-?, TGF-?1, cyclin D1, metalloproteinase matrix-9 (MMP-9) and heparinase production as well as regulating the host immune response and induce epithelial-mesenchymal transition (EMT). Conclusion: the use of in vivo and in vitro studies is very significant for understanding the casual association of these biological processes. The current findings highlight the importance of further studies in this area to understand the cause and effect relationship of these pathologies and the development of new strategies for the prevention and treatment of this type of cancer
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spelling Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular MechanismsRevisão dos Dados Experimentais in vivo e in vitro que Apoiam à Carcinogênese do Carcinoma de Células Escamosas Oral por Doença Periodontal e Possíveis Mecanismos MolecularesDENTAL MEDICINE (DENTISTRY)Mouth neoplasms; Periodontal disease; Molecular mechanism; P. gingivalis; InflammationMEDICINA DENTÁRIA (ODONTOLOGIA)Neoplasias bucais; Doença periodontal; Mecanismo molecular; P. gingivalis; InflamaçãoObjective: to describe different in vivo and in vitro experimental models and summarize evidence that proposes molecular mechanisms or demonstrate a cause and effect correlation between periodontal disease (PD) and oral squamous cell carcinoma development. Material and Methods: a Literature search of various electronic databases (Medline, SCOPUS, Web of Science) using appropriate keywords (e.g., periodontal disease, periodontitis, squamous cell carcinoma, oral cancer, transformation, carcinogenesis, mouth neoplasms, and carcinoma) was performed. Then, a comprehensive literature review of the current understanding of this link was elaborated. Results: the experimental data suggest that PD induces initiation, promotion, and oral squamous cell carcinoma progression. Periodontal disease models here revised demonstrate a direct relation to carcinogenesis and propose several possible molecular mechanisms of action, such as via activation of Toll-like receptors (TLRs), activation of transcription 3 activator (STAT3) and Notch1 pathways and increased interleukin-6 (IL-6), TNF-?, TGF-?1, cyclin D1, metalloproteinase matrix-9 (MMP-9) and heparinase production as well as regulating the host immune response and induce epithelial-mesenchymal transition (EMT). Conclusion: the use of in vivo and in vitro studies is very significant for understanding the casual association of these biological processes. The current findings highlight the importance of further studies in this area to understand the cause and effect relationship of these pathologies and the development of new strategies for the prevention and treatment of this type of cancerObjetivo: Descrever diferentes modelos experimentais in vivo e in vitro e resumir evidências que proponham mecanismo molecular ou que demonstrem uma correlação de causa e efeito entre doença periodontal (DP) e desenvolvimento de carcinoma de células escamosas de boca. Material e métodos: Uma pesquisa bibliográfica de vários bancos de dados eletrônicos (Medline, SCOPUS, Web of Science) usando palavras-chave apropriadas (por exemplo, doença periodontal, periodontite, carcinoma de células escamosas, câncer oral, transformação, carcinogênese, neoplasias bucais e carcinoma) foi realizada. Em seguida, foi elaborada uma revisão abrangente da literatura sobre o entendimento atual dessa ligação. Resultados: Os dados experimentais sugerem que a DP induz a iniciação, promoção e progressão do carcinoma de células escamosas de boca. Modelos de doença periodontal aqui revisados demonstram uma relação direta com a carcinogênese e propõem vários possíveis mecanismos moleculares de ação, como a via ativação de receptores Toll-like (TLRs), ativação do ativador de transcrição 3 (STAT3) e vias de Notch1 e aumento da interleucina-6 (IL- 6), produção de TNF-?, TGF-?1, ciclina D1, metaloproteinase de matriz 9(MMP-9) e heparinase, além de regular a resposta imune do hospedeiro e induzir a transição epitélio-mesenquimal (TEM). Conclusão: O uso de estudos in vivo e in vitro é muito significativo para o entendimento da associação causal desses processos biológicos. Os achados atuais destacam a importância de novos estudos nesta área para entender a relação de causa e efeito dessas patologias e para o desenvolvimento de novas estratégias de prevenção e tratamento desse tipo de câncer.Associação Brasileira de Odontologia - Seção Rio de JaneiroSilva, Rafael Carriello daAraujo, Geisoellen FelicioPascoal, Vinicius D'avila BitencourtCamargo, Gabriela Alessandra Cruz GalhardoRobbs, Bruno Kaufmann2021-02-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLiterature ReviewRevisão de Literaturaapplication/pdfhttps://revista.aborj.org.br/index.php/rbo/article/view/193010.18363/rbo.v78.2021.e1930Revista Brasileira de Odontologia; v. 78 (2021); 1/9Revista Brasileira de Odontologia; v. 78 (2021); 1/91984-3747reponame:Revista Brasileira de Odontologiainstname:Associação Brasileira de Odontologia (ABO)instacron:ABOenghttps://revista.aborj.org.br/index.php/rbo/article/view/1930/pdfhttps://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1930/2323https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1930/2324https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1930/2325Direitos autorais 2021 Revi. Bras. Odontol.http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess2021-05-24T14:35:33Zoai:revista_aborj_org_br.www.revista.aborj.org.br:article/1930Revistahttps://revista.aborj.org.br/index.php/rboONGhttp://www.revista.aborj.org.br/index.php/rbo/oaihttps://revista.aborj.org.br/index.php/rbo/oai0034-72721984-3747opendoar:2021-05-24T14:35:33Revista Brasileira de Odontologia - Associação Brasileira de Odontologia (ABO)false
dc.title.none.fl_str_mv Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms
Revisão dos Dados Experimentais in vivo e in vitro que Apoiam à Carcinogênese do Carcinoma de Células Escamosas Oral por Doença Periodontal e Possíveis Mecanismos Moleculares
title Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms
spellingShingle Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms
Silva, Rafael Carriello da
DENTAL MEDICINE (DENTISTRY)
Mouth neoplasms; Periodontal disease; Molecular mechanism; P. gingivalis; Inflammation
MEDICINA DENTÁRIA (ODONTOLOGIA)
Neoplasias bucais; Doença periodontal; Mecanismo molecular; P. gingivalis; Inflamação
title_short Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms
title_full Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms
title_fullStr Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms
title_full_unstemmed Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms
title_sort Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms
author Silva, Rafael Carriello da
author_facet Silva, Rafael Carriello da
Araujo, Geisoellen Felicio
Pascoal, Vinicius D'avila Bitencourt
Camargo, Gabriela Alessandra Cruz Galhardo
Robbs, Bruno Kaufmann
author_role author
author2 Araujo, Geisoellen Felicio
Pascoal, Vinicius D'avila Bitencourt
Camargo, Gabriela Alessandra Cruz Galhardo
Robbs, Bruno Kaufmann
author2_role author
author
author
author
dc.contributor.none.fl_str_mv

dc.contributor.author.fl_str_mv Silva, Rafael Carriello da
Araujo, Geisoellen Felicio
Pascoal, Vinicius D'avila Bitencourt
Camargo, Gabriela Alessandra Cruz Galhardo
Robbs, Bruno Kaufmann
dc.subject.none.fl_str_mv

dc.subject.por.fl_str_mv DENTAL MEDICINE (DENTISTRY)
Mouth neoplasms; Periodontal disease; Molecular mechanism; P. gingivalis; Inflammation
MEDICINA DENTÁRIA (ODONTOLOGIA)
Neoplasias bucais; Doença periodontal; Mecanismo molecular; P. gingivalis; Inflamação
topic DENTAL MEDICINE (DENTISTRY)
Mouth neoplasms; Periodontal disease; Molecular mechanism; P. gingivalis; Inflammation
MEDICINA DENTÁRIA (ODONTOLOGIA)
Neoplasias bucais; Doença periodontal; Mecanismo molecular; P. gingivalis; Inflamação
description Objective: to describe different in vivo and in vitro experimental models and summarize evidence that proposes molecular mechanisms or demonstrate a cause and effect correlation between periodontal disease (PD) and oral squamous cell carcinoma development. Material and Methods: a Literature search of various electronic databases (Medline, SCOPUS, Web of Science) using appropriate keywords (e.g., periodontal disease, periodontitis, squamous cell carcinoma, oral cancer, transformation, carcinogenesis, mouth neoplasms, and carcinoma) was performed. Then, a comprehensive literature review of the current understanding of this link was elaborated. Results: the experimental data suggest that PD induces initiation, promotion, and oral squamous cell carcinoma progression. Periodontal disease models here revised demonstrate a direct relation to carcinogenesis and propose several possible molecular mechanisms of action, such as via activation of Toll-like receptors (TLRs), activation of transcription 3 activator (STAT3) and Notch1 pathways and increased interleukin-6 (IL-6), TNF-?, TGF-?1, cyclin D1, metalloproteinase matrix-9 (MMP-9) and heparinase production as well as regulating the host immune response and induce epithelial-mesenchymal transition (EMT). Conclusion: the use of in vivo and in vitro studies is very significant for understanding the casual association of these biological processes. The current findings highlight the importance of further studies in this area to understand the cause and effect relationship of these pathologies and the development of new strategies for the prevention and treatment of this type of cancer
publishDate 2021
dc.date.none.fl_str_mv 2021-02-08
dc.type.none.fl_str_mv

dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Literature Review
Revisão de Literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revista.aborj.org.br/index.php/rbo/article/view/1930
10.18363/rbo.v78.2021.e1930
url https://revista.aborj.org.br/index.php/rbo/article/view/1930
identifier_str_mv 10.18363/rbo.v78.2021.e1930
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revista.aborj.org.br/index.php/rbo/article/view/1930/pdf
https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1930/2323
https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1930/2324
https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1930/2325
dc.rights.driver.fl_str_mv Direitos autorais 2021 Revi. Bras. Odontol.
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Direitos autorais 2021 Revi. Bras. Odontol.
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.coverage.none.fl_str_mv





dc.publisher.none.fl_str_mv Associação Brasileira de Odontologia - Seção Rio de Janeiro
publisher.none.fl_str_mv Associação Brasileira de Odontologia - Seção Rio de Janeiro
dc.source.none.fl_str_mv Revista Brasileira de Odontologia; v. 78 (2021); 1/9
Revista Brasileira de Odontologia; v. 78 (2021); 1/9
1984-3747
reponame:Revista Brasileira de Odontologia
instname:Associação Brasileira de Odontologia (ABO)
instacron:ABO
instname_str Associação Brasileira de Odontologia (ABO)
instacron_str ABO
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reponame_str Revista Brasileira de Odontologia
collection Revista Brasileira de Odontologia
repository.name.fl_str_mv Revista Brasileira de Odontologia - Associação Brasileira de Odontologia (ABO)
repository.mail.fl_str_mv https://revista.aborj.org.br/index.php/rbo/oai
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