Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Odontologia |
Texto Completo: | https://revista.aborj.org.br/index.php/rbo/article/view/1930 |
Resumo: | Objective: to describe different in vivo and in vitro experimental models and summarize evidence that proposes molecular mechanisms or demonstrate a cause and effect correlation between periodontal disease (PD) and oral squamous cell carcinoma development. Material and Methods: a Literature search of various electronic databases (Medline, SCOPUS, Web of Science) using appropriate keywords (e.g., periodontal disease, periodontitis, squamous cell carcinoma, oral cancer, transformation, carcinogenesis, mouth neoplasms, and carcinoma) was performed. Then, a comprehensive literature review of the current understanding of this link was elaborated. Results: the experimental data suggest that PD induces initiation, promotion, and oral squamous cell carcinoma progression. Periodontal disease models here revised demonstrate a direct relation to carcinogenesis and propose several possible molecular mechanisms of action, such as via activation of Toll-like receptors (TLRs), activation of transcription 3 activator (STAT3) and Notch1 pathways and increased interleukin-6 (IL-6), TNF-?, TGF-?1, cyclin D1, metalloproteinase matrix-9 (MMP-9) and heparinase production as well as regulating the host immune response and induce epithelial-mesenchymal transition (EMT). Conclusion: the use of in vivo and in vitro studies is very significant for understanding the casual association of these biological processes. The current findings highlight the importance of further studies in this area to understand the cause and effect relationship of these pathologies and the development of new strategies for the prevention and treatment of this type of cancer |
id |
ABO-1_6d59deba549ccffee5ca6990c3db758f |
---|---|
oai_identifier_str |
oai:revista_aborj_org_br.www.revista.aborj.org.br:article/1930 |
network_acronym_str |
ABO-1 |
network_name_str |
Revista Brasileira de Odontologia |
repository_id_str |
|
spelling |
Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular MechanismsRevisão dos Dados Experimentais in vivo e in vitro que Apoiam à Carcinogênese do Carcinoma de Células Escamosas Oral por Doença Periodontal e Possíveis Mecanismos MolecularesDENTAL MEDICINE (DENTISTRY)Mouth neoplasms; Periodontal disease; Molecular mechanism; P. gingivalis; InflammationMEDICINA DENTÁRIA (ODONTOLOGIA)Neoplasias bucais; Doença periodontal; Mecanismo molecular; P. gingivalis; InflamaçãoObjective: to describe different in vivo and in vitro experimental models and summarize evidence that proposes molecular mechanisms or demonstrate a cause and effect correlation between periodontal disease (PD) and oral squamous cell carcinoma development. Material and Methods: a Literature search of various electronic databases (Medline, SCOPUS, Web of Science) using appropriate keywords (e.g., periodontal disease, periodontitis, squamous cell carcinoma, oral cancer, transformation, carcinogenesis, mouth neoplasms, and carcinoma) was performed. Then, a comprehensive literature review of the current understanding of this link was elaborated. Results: the experimental data suggest that PD induces initiation, promotion, and oral squamous cell carcinoma progression. Periodontal disease models here revised demonstrate a direct relation to carcinogenesis and propose several possible molecular mechanisms of action, such as via activation of Toll-like receptors (TLRs), activation of transcription 3 activator (STAT3) and Notch1 pathways and increased interleukin-6 (IL-6), TNF-?, TGF-?1, cyclin D1, metalloproteinase matrix-9 (MMP-9) and heparinase production as well as regulating the host immune response and induce epithelial-mesenchymal transition (EMT). Conclusion: the use of in vivo and in vitro studies is very significant for understanding the casual association of these biological processes. The current findings highlight the importance of further studies in this area to understand the cause and effect relationship of these pathologies and the development of new strategies for the prevention and treatment of this type of cancerObjetivo: Descrever diferentes modelos experimentais in vivo e in vitro e resumir evidências que proponham mecanismo molecular ou que demonstrem uma correlação de causa e efeito entre doença periodontal (DP) e desenvolvimento de carcinoma de células escamosas de boca. Material e métodos: Uma pesquisa bibliográfica de vários bancos de dados eletrônicos (Medline, SCOPUS, Web of Science) usando palavras-chave apropriadas (por exemplo, doença periodontal, periodontite, carcinoma de células escamosas, câncer oral, transformação, carcinogênese, neoplasias bucais e carcinoma) foi realizada. Em seguida, foi elaborada uma revisão abrangente da literatura sobre o entendimento atual dessa ligação. Resultados: Os dados experimentais sugerem que a DP induz a iniciação, promoção e progressão do carcinoma de células escamosas de boca. Modelos de doença periodontal aqui revisados demonstram uma relação direta com a carcinogênese e propõem vários possíveis mecanismos moleculares de ação, como a via ativação de receptores Toll-like (TLRs), ativação do ativador de transcrição 3 (STAT3) e vias de Notch1 e aumento da interleucina-6 (IL- 6), produção de TNF-?, TGF-?1, ciclina D1, metaloproteinase de matriz 9(MMP-9) e heparinase, além de regular a resposta imune do hospedeiro e induzir a transição epitélio-mesenquimal (TEM). Conclusão: O uso de estudos in vivo e in vitro é muito significativo para o entendimento da associação causal desses processos biológicos. Os achados atuais destacam a importância de novos estudos nesta área para entender a relação de causa e efeito dessas patologias e para o desenvolvimento de novas estratégias de prevenção e tratamento desse tipo de câncer.Associação Brasileira de Odontologia - Seção Rio de JaneiroSilva, Rafael Carriello daAraujo, Geisoellen FelicioPascoal, Vinicius D'avila BitencourtCamargo, Gabriela Alessandra Cruz GalhardoRobbs, Bruno Kaufmann2021-02-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLiterature ReviewRevisão de Literaturaapplication/pdfhttps://revista.aborj.org.br/index.php/rbo/article/view/193010.18363/rbo.v78.2021.e1930Revista Brasileira de Odontologia; v. 78 (2021); 1/9Revista Brasileira de Odontologia; v. 78 (2021); 1/91984-3747reponame:Revista Brasileira de Odontologiainstname:Associação Brasileira de Odontologia (ABO)instacron:ABOenghttps://revista.aborj.org.br/index.php/rbo/article/view/1930/pdfhttps://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1930/2323https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1930/2324https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1930/2325Direitos autorais 2021 Revi. Bras. Odontol.http://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess2021-05-24T14:35:33Zoai:revista_aborj_org_br.www.revista.aborj.org.br:article/1930Revistahttps://revista.aborj.org.br/index.php/rboONGhttp://www.revista.aborj.org.br/index.php/rbo/oaihttps://revista.aborj.org.br/index.php/rbo/oai0034-72721984-3747opendoar:2021-05-24T14:35:33Revista Brasileira de Odontologia - Associação Brasileira de Odontologia (ABO)false |
dc.title.none.fl_str_mv |
Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms Revisão dos Dados Experimentais in vivo e in vitro que Apoiam à Carcinogênese do Carcinoma de Células Escamosas Oral por Doença Periodontal e Possíveis Mecanismos Moleculares |
title |
Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms |
spellingShingle |
Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms Silva, Rafael Carriello da DENTAL MEDICINE (DENTISTRY) Mouth neoplasms; Periodontal disease; Molecular mechanism; P. gingivalis; Inflammation MEDICINA DENTÁRIA (ODONTOLOGIA) Neoplasias bucais; Doença periodontal; Mecanismo molecular; P. gingivalis; Inflamação |
title_short |
Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms |
title_full |
Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms |
title_fullStr |
Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms |
title_full_unstemmed |
Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms |
title_sort |
Review of Experimental Data in vivo and in vitro Supporting Carcinogenesis of Oral Squamous Cell Carcinoma by Periodontal Disease and Possible Molecular Mechanisms |
author |
Silva, Rafael Carriello da |
author_facet |
Silva, Rafael Carriello da Araujo, Geisoellen Felicio Pascoal, Vinicius D'avila Bitencourt Camargo, Gabriela Alessandra Cruz Galhardo Robbs, Bruno Kaufmann |
author_role |
author |
author2 |
Araujo, Geisoellen Felicio Pascoal, Vinicius D'avila Bitencourt Camargo, Gabriela Alessandra Cruz Galhardo Robbs, Bruno Kaufmann |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
|
dc.contributor.author.fl_str_mv |
Silva, Rafael Carriello da Araujo, Geisoellen Felicio Pascoal, Vinicius D'avila Bitencourt Camargo, Gabriela Alessandra Cruz Galhardo Robbs, Bruno Kaufmann |
dc.subject.none.fl_str_mv |
|
dc.subject.por.fl_str_mv |
DENTAL MEDICINE (DENTISTRY) Mouth neoplasms; Periodontal disease; Molecular mechanism; P. gingivalis; Inflammation MEDICINA DENTÁRIA (ODONTOLOGIA) Neoplasias bucais; Doença periodontal; Mecanismo molecular; P. gingivalis; Inflamação |
topic |
DENTAL MEDICINE (DENTISTRY) Mouth neoplasms; Periodontal disease; Molecular mechanism; P. gingivalis; Inflammation MEDICINA DENTÁRIA (ODONTOLOGIA) Neoplasias bucais; Doença periodontal; Mecanismo molecular; P. gingivalis; Inflamação |
description |
Objective: to describe different in vivo and in vitro experimental models and summarize evidence that proposes molecular mechanisms or demonstrate a cause and effect correlation between periodontal disease (PD) and oral squamous cell carcinoma development. Material and Methods: a Literature search of various electronic databases (Medline, SCOPUS, Web of Science) using appropriate keywords (e.g., periodontal disease, periodontitis, squamous cell carcinoma, oral cancer, transformation, carcinogenesis, mouth neoplasms, and carcinoma) was performed. Then, a comprehensive literature review of the current understanding of this link was elaborated. Results: the experimental data suggest that PD induces initiation, promotion, and oral squamous cell carcinoma progression. Periodontal disease models here revised demonstrate a direct relation to carcinogenesis and propose several possible molecular mechanisms of action, such as via activation of Toll-like receptors (TLRs), activation of transcription 3 activator (STAT3) and Notch1 pathways and increased interleukin-6 (IL-6), TNF-?, TGF-?1, cyclin D1, metalloproteinase matrix-9 (MMP-9) and heparinase production as well as regulating the host immune response and induce epithelial-mesenchymal transition (EMT). Conclusion: the use of in vivo and in vitro studies is very significant for understanding the casual association of these biological processes. The current findings highlight the importance of further studies in this area to understand the cause and effect relationship of these pathologies and the development of new strategies for the prevention and treatment of this type of cancer |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-02-08 |
dc.type.none.fl_str_mv |
|
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Literature Review Revisão de Literatura |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revista.aborj.org.br/index.php/rbo/article/view/1930 10.18363/rbo.v78.2021.e1930 |
url |
https://revista.aborj.org.br/index.php/rbo/article/view/1930 |
identifier_str_mv |
10.18363/rbo.v78.2021.e1930 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revista.aborj.org.br/index.php/rbo/article/view/1930/pdf https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1930/2323 https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1930/2324 https://revista.aborj.org.br/index.php/rbo/article/downloadSuppFile/1930/2325 |
dc.rights.driver.fl_str_mv |
Direitos autorais 2021 Revi. Bras. Odontol. http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Direitos autorais 2021 Revi. Bras. Odontol. http://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
|
dc.publisher.none.fl_str_mv |
Associação Brasileira de Odontologia - Seção Rio de Janeiro |
publisher.none.fl_str_mv |
Associação Brasileira de Odontologia - Seção Rio de Janeiro |
dc.source.none.fl_str_mv |
Revista Brasileira de Odontologia; v. 78 (2021); 1/9 Revista Brasileira de Odontologia; v. 78 (2021); 1/9 1984-3747 reponame:Revista Brasileira de Odontologia instname:Associação Brasileira de Odontologia (ABO) instacron:ABO |
instname_str |
Associação Brasileira de Odontologia (ABO) |
instacron_str |
ABO |
institution |
ABO |
reponame_str |
Revista Brasileira de Odontologia |
collection |
Revista Brasileira de Odontologia |
repository.name.fl_str_mv |
Revista Brasileira de Odontologia - Associação Brasileira de Odontologia (ABO) |
repository.mail.fl_str_mv |
https://revista.aborj.org.br/index.php/rbo/oai |
_version_ |
1798313204861894656 |