The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462017000200090 |
Resumo: | Objective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear. The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults. Methods: Eighty-seven subjects aged > 55 years were recruited using a community-based convenience sampling strategy in Porto Alegre, Brazil. The logical memory subset of the Wechsler Memory Scale-Revised was used to assess immediate verbal recall (IVR), delayed verbal recall (DVR), and memory retention rate. Results: BDNF Met allele carriers had lower DVR scores (p = 0.004) and a decline in memory retention (p = 0.017) when compared to Val/Val homozygotes. However, we found no significant differences in IVR between the two groups (p = 0.088). Conclusion: These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults. |
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Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
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The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adultsAgingbrain-derived neurotrophic factorcognitionmemorypolymorphism Objective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear. The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults. Methods: Eighty-seven subjects aged > 55 years were recruited using a community-based convenience sampling strategy in Porto Alegre, Brazil. The logical memory subset of the Wechsler Memory Scale-Revised was used to assess immediate verbal recall (IVR), delayed verbal recall (DVR), and memory retention rate. Results: BDNF Met allele carriers had lower DVR scores (p = 0.004) and a decline in memory retention (p = 0.017) when compared to Val/Val homozygotes. However, we found no significant differences in IVR between the two groups (p = 0.088). Conclusion: These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults.Associação Brasileira de Psiquiatria2017-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462017000200090Brazilian Journal of Psychiatry v.39 n.2 2017reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online)instname:Associação Brasileira de Psiquiatria (ABP)instacron:ABP10.1590/1516-4446-2016-1980info:eu-repo/semantics/openAccessAzeredo,Lucas A. deDe Nardi,TatianaLevandowski,Mateus L.Tractenberg,Saulo G.Kommers-Molina,JuliaWieck,AndreaIrigaray,Tatiana Q.Silva Filho,Irênio G. daGrassi-Oliveira,Rodrigoeng2017-06-13T00:00:00Zoai:scielo:S1516-44462017000200090Revistahttp://www.bjp.org.br/ahead_of_print.asphttps://old.scielo.br/oai/scielo-oai.php||rbp@abpbrasil.org.br1809-452X1516-4446opendoar:2017-06-13T00:00Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP)false |
dc.title.none.fl_str_mv |
The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults |
title |
The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults |
spellingShingle |
The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults Azeredo,Lucas A. de Aging brain-derived neurotrophic factor cognition memory polymorphism |
title_short |
The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults |
title_full |
The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults |
title_fullStr |
The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults |
title_full_unstemmed |
The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults |
title_sort |
The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults |
author |
Azeredo,Lucas A. de |
author_facet |
Azeredo,Lucas A. de De Nardi,Tatiana Levandowski,Mateus L. Tractenberg,Saulo G. Kommers-Molina,Julia Wieck,Andrea Irigaray,Tatiana Q. Silva Filho,Irênio G. da Grassi-Oliveira,Rodrigo |
author_role |
author |
author2 |
De Nardi,Tatiana Levandowski,Mateus L. Tractenberg,Saulo G. Kommers-Molina,Julia Wieck,Andrea Irigaray,Tatiana Q. Silva Filho,Irênio G. da Grassi-Oliveira,Rodrigo |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Azeredo,Lucas A. de De Nardi,Tatiana Levandowski,Mateus L. Tractenberg,Saulo G. Kommers-Molina,Julia Wieck,Andrea Irigaray,Tatiana Q. Silva Filho,Irênio G. da Grassi-Oliveira,Rodrigo |
dc.subject.por.fl_str_mv |
Aging brain-derived neurotrophic factor cognition memory polymorphism |
topic |
Aging brain-derived neurotrophic factor cognition memory polymorphism |
description |
Objective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associated with impaired episodic memory in adults, but whether this functional variant plays a role in cognitive aging remains unclear. The purpose of this study was to investigate the effects of the BDNF Val66Met polymorphism on memory performance in a sample of elderly adults. Methods: Eighty-seven subjects aged > 55 years were recruited using a community-based convenience sampling strategy in Porto Alegre, Brazil. The logical memory subset of the Wechsler Memory Scale-Revised was used to assess immediate verbal recall (IVR), delayed verbal recall (DVR), and memory retention rate. Results: BDNF Met allele carriers had lower DVR scores (p = 0.004) and a decline in memory retention (p = 0.017) when compared to Val/Val homozygotes. However, we found no significant differences in IVR between the two groups (p = 0.088). Conclusion: These results support the hypothesis of the BDNF Val66Met polymorphism as a risk factor associated with cognitive impairment, corroborating previous findings in young and older adults. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462017000200090 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462017000200090 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1516-4446-2016-1980 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
publisher.none.fl_str_mv |
Associação Brasileira de Psiquiatria |
dc.source.none.fl_str_mv |
Brazilian Journal of Psychiatry v.39 n.2 2017 reponame:Brazilian Journal of Psychiatry (São Paulo. 1999. Online) instname:Associação Brasileira de Psiquiatria (ABP) instacron:ABP |
instname_str |
Associação Brasileira de Psiquiatria (ABP) |
instacron_str |
ABP |
institution |
ABP |
reponame_str |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
collection |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) |
repository.name.fl_str_mv |
Brazilian Journal of Psychiatry (São Paulo. 1999. Online) - Associação Brasileira de Psiquiatria (ABP) |
repository.mail.fl_str_mv |
||rbp@abpbrasil.org.br |
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1754212557712785408 |