Behavioral effect in experimental models of depression by gastrin releasing peptide microinjection via intra nucleus accumbens

• Autor(a) principal: Almeida, Rodrigo de
• Data de Publicação: 2021
• Outros Autores: Henna Neto, Jorge, Silva, Eduardo Ernani Piazza da
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Debates em Psiquiatria (Online)
• Texto Completo: https://revistardp.org.br/revista/article/view/221
• topic: transtorno depressivo maior; depressão; GRP; Major Depressive Disorder; Depression; GRP; Trastorno depresivo mayor; Depresión; GRP

Introduction: Major Depressive Disorder is a common medical condition in the population, which can affect not only mental capacity, but also physical capacity, even causing incapacity for work. Its cause is still unknown, although some theories are gaining ground, such as the neurogenesis hypotheses as well as the neuroplasticity hypothesis, which emerged in a context where the classic monoamine hypothesis no longer explains all cases. In this context, a strong association between hyperactivity of the hypothalamic-pituitary-adrenal axis as well as gastroin-testinal tract hormones was highlighted in studies raising the hypothesis that depression has associated metabolic factors, even leading to the characterization of metabolic disease ac-cording to some authors. Objective: Thus, the present study seeks to analyze the behavioral effect of the gastrointestinal tract hormone GRP in view of the present evidence on its possible relationship with the patho-physiology of depression. Methods: Twenty Swiss mice were selected to perform the social defeat procedure, analysis with forced swimming test and intervention with Fluoxetine in the control and GRP in the experimental. Results: Social defeat stress increased the immobility time in the forced swim test by 13 seconds in the submissive mice, the GRP injection reduced the immobility time with a difference of 78 seconds for the control group treated with Fluoxetine. Conclusion: Thus, GRP, compared to other hor-mones studied in depression, had a positive effect on depres-sion and a possible therapy for its treatment.