Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids

Detalhes bibliográficos
Autor(a) principal: Bruder-Nascimento,Thiago
Data de Publicação: 2015
Outros Autores: Silva,Samuel T., Boer,Patrícia A., Cordellini,Sandra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Physical Therapy
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-35552015000300177
Resumo: Background: Physical exercise may modify biologic stress responses. Objective: To investigate the impact of exercise training on vascular alterations induced by acute stress, focusing on nitric oxide and cyclooxygenase pathways. Method: Wistar rats were separated into: sedentary, trained (60-min swimming, 5 days/week during 8 weeks, carrying a 5% body-weight load), stressed (2 h-immobilization), and trained/stressed. Response curves for noradrenaline, in the absence and presence of L-NAME or indomethacin, were obtained in intact and denuded aortas (n=7-10). Results: None of the procedures altered the denuded aorta reactivity. Intact aortas from stressed, trained, and trained/stressed rats showed similar reduction in noradrenaline maximal responses (sedentary 3.54±0.15, stressed 2.80±0.10*, trained 2.82±0.11*, trained/stressed 2.97± 0.21*, *P<0.05 relate to sedentary). Endothelium removal and L-NAME abolished this hyporeactivity in all experimental groups, except in trained/stressed rats that showed a partial aorta reactivity recovery in L-NAME presence (L-NAME: sedentary 5.23±0,26#, stressed 5.55±0.38#, trained 5.28±0.30#, trained/stressed 4.42±0.41, #P<0.05 related to trained/stressed). Indomethacin determined a decrease in sensitivity (EC50) in intact aortas of trained rats without abolishing the aortal hyporeactivity in trained, stressed, and trained/stressed rats. Conclusions: Exercise-induced vascular adaptive response involved an increase in endothelial vasodilator prostaglandins and nitric oxide. Stress-induced vascular adaptive response involved an increase in endothelial nitric oxide. Beside the involvement of the endothelial nitric oxide pathway, the vascular response of trained/stressed rats involved an additional mechanism yet to be elucidated. These findings advance on the understanding of the vascular processes after exercise and stress alone and in combination.
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spelling Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoidsvasodilator prostanoidsnitric oxideexercise trainingacute stressaorta reactivityphysical therapy Background: Physical exercise may modify biologic stress responses. Objective: To investigate the impact of exercise training on vascular alterations induced by acute stress, focusing on nitric oxide and cyclooxygenase pathways. Method: Wistar rats were separated into: sedentary, trained (60-min swimming, 5 days/week during 8 weeks, carrying a 5% body-weight load), stressed (2 h-immobilization), and trained/stressed. Response curves for noradrenaline, in the absence and presence of L-NAME or indomethacin, were obtained in intact and denuded aortas (n=7-10). Results: None of the procedures altered the denuded aorta reactivity. Intact aortas from stressed, trained, and trained/stressed rats showed similar reduction in noradrenaline maximal responses (sedentary 3.54±0.15, stressed 2.80±0.10*, trained 2.82±0.11*, trained/stressed 2.97± 0.21*, *P<0.05 relate to sedentary). Endothelium removal and L-NAME abolished this hyporeactivity in all experimental groups, except in trained/stressed rats that showed a partial aorta reactivity recovery in L-NAME presence (L-NAME: sedentary 5.23±0,26#, stressed 5.55±0.38#, trained 5.28±0.30#, trained/stressed 4.42±0.41, #P<0.05 related to trained/stressed). Indomethacin determined a decrease in sensitivity (EC50) in intact aortas of trained rats without abolishing the aortal hyporeactivity in trained, stressed, and trained/stressed rats. Conclusions: Exercise-induced vascular adaptive response involved an increase in endothelial vasodilator prostaglandins and nitric oxide. Stress-induced vascular adaptive response involved an increase in endothelial nitric oxide. Beside the involvement of the endothelial nitric oxide pathway, the vascular response of trained/stressed rats involved an additional mechanism yet to be elucidated. These findings advance on the understanding of the vascular processes after exercise and stress alone and in combination. Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia 2015-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-35552015000300177Brazilian Journal of Physical Therapy v.19 n.3 2015reponame:Brazilian Journal of Physical Therapyinstname:Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia (ABRAPG-FT)instacron:ABRAPG-FT10.1590/bjpt-rbf.2014.0088info:eu-repo/semantics/openAccessBruder-Nascimento,ThiagoSilva,Samuel T.Boer,Patrícia A.Cordellini,Sandraeng2015-07-30T00:00:00Zoai:scielo:S1413-35552015000300177Revistahttps://www.scielo.br/j/rbfis/https://old.scielo.br/oai/scielo-oai.phpcontato@rbf-bjpt.org.br||contato@rbf-bjpt.org.br1809-92461413-3555opendoar:2015-07-30T00:00Brazilian Journal of Physical Therapy - Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia (ABRAPG-FT)false
dc.title.none.fl_str_mv Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
title Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
spellingShingle Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
Bruder-Nascimento,Thiago
vasodilator prostanoids
nitric oxide
exercise training
acute stress
aorta reactivity
physical therapy
title_short Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
title_full Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
title_fullStr Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
title_full_unstemmed Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
title_sort Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
author Bruder-Nascimento,Thiago
author_facet Bruder-Nascimento,Thiago
Silva,Samuel T.
Boer,Patrícia A.
Cordellini,Sandra
author_role author
author2 Silva,Samuel T.
Boer,Patrícia A.
Cordellini,Sandra
author2_role author
author
author
dc.contributor.author.fl_str_mv Bruder-Nascimento,Thiago
Silva,Samuel T.
Boer,Patrícia A.
Cordellini,Sandra
dc.subject.por.fl_str_mv vasodilator prostanoids
nitric oxide
exercise training
acute stress
aorta reactivity
physical therapy
topic vasodilator prostanoids
nitric oxide
exercise training
acute stress
aorta reactivity
physical therapy
description Background: Physical exercise may modify biologic stress responses. Objective: To investigate the impact of exercise training on vascular alterations induced by acute stress, focusing on nitric oxide and cyclooxygenase pathways. Method: Wistar rats were separated into: sedentary, trained (60-min swimming, 5 days/week during 8 weeks, carrying a 5% body-weight load), stressed (2 h-immobilization), and trained/stressed. Response curves for noradrenaline, in the absence and presence of L-NAME or indomethacin, were obtained in intact and denuded aortas (n=7-10). Results: None of the procedures altered the denuded aorta reactivity. Intact aortas from stressed, trained, and trained/stressed rats showed similar reduction in noradrenaline maximal responses (sedentary 3.54±0.15, stressed 2.80±0.10*, trained 2.82±0.11*, trained/stressed 2.97± 0.21*, *P<0.05 relate to sedentary). Endothelium removal and L-NAME abolished this hyporeactivity in all experimental groups, except in trained/stressed rats that showed a partial aorta reactivity recovery in L-NAME presence (L-NAME: sedentary 5.23±0,26#, stressed 5.55±0.38#, trained 5.28±0.30#, trained/stressed 4.42±0.41, #P<0.05 related to trained/stressed). Indomethacin determined a decrease in sensitivity (EC50) in intact aortas of trained rats without abolishing the aortal hyporeactivity in trained, stressed, and trained/stressed rats. Conclusions: Exercise-induced vascular adaptive response involved an increase in endothelial vasodilator prostaglandins and nitric oxide. Stress-induced vascular adaptive response involved an increase in endothelial nitric oxide. Beside the involvement of the endothelial nitric oxide pathway, the vascular response of trained/stressed rats involved an additional mechanism yet to be elucidated. These findings advance on the understanding of the vascular processes after exercise and stress alone and in combination.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-35552015000300177
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-35552015000300177
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/bjpt-rbf.2014.0088
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia
publisher.none.fl_str_mv Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia
dc.source.none.fl_str_mv Brazilian Journal of Physical Therapy v.19 n.3 2015
reponame:Brazilian Journal of Physical Therapy
instname:Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia (ABRAPG-FT)
instacron:ABRAPG-FT
instname_str Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia (ABRAPG-FT)
instacron_str ABRAPG-FT
institution ABRAPG-FT
reponame_str Brazilian Journal of Physical Therapy
collection Brazilian Journal of Physical Therapy
repository.name.fl_str_mv Brazilian Journal of Physical Therapy - Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia (ABRAPG-FT)
repository.mail.fl_str_mv contato@rbf-bjpt.org.br||contato@rbf-bjpt.org.br
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