Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids

Detalhes bibliográficos
Autor(a) principal: Bruder-Nascimento, Thiago [UNESP]
Data de Publicação: 2015
Outros Autores: Silva, Samuel T. [UNESP], Boer, Patrícia A., Cordellini, Sandra [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-35552015000300177&lng=en&nrm=iso&tlng=en
http://hdl.handle.net/11449/127471
Resumo: Background: Physical exercise may modify biologic stress responses. Objective: To investigate the impact of exercise training on vascular alterations induced by acute stress, focusing on nitric oxide and cyclooxygenase pathways. Method: Wistar rats were separated into: sedentary, trained (60-min swimming, 5 days/week during 8 weeks, carrying a 5% body-weight load), stressed (2 h-immobilization), and trained/stressed. Response curves for noradrenaline, in the absence and presence of L-NAME or indomethacin, were obtained in intact and denuded aortas (n=7-10). Results: None of the procedures altered the denuded aorta reactivity. Intact aortas from stressed, trained, and trained/stressed rats showed similar reduction in noradrenaline maximal responses (sedentary 3.54±0.15, stressed 2.80±0.10*, trained 2.82±0.11*, trained/stressed 2.97± 0.21*, *P<0.05 relate to sedentary). Endothelium removal and L-NAME abolished this hyporeactivity in all experimental groups, except in trained/stressed rats that showed a partial aorta reactivity recovery in L-NAME presence (L-NAME: sedentary 5.23±0,26#, stressed 5.55±0.38#, trained 5.28±0.30#, trained/stressed 4.42±0.41, #P<0.05 related to trained/stressed). Indomethacin determined a decrease in sensitivity (EC50) in intact aortas of trained rats without abolishing the aortal hyporeactivity in trained, stressed, and trained/stressed rats. Conclusions: Exercise-induced vascular adaptive response involved an increase in endothelial vasodilator prostaglandins and nitric oxide. Stress-induced vascular adaptive response involved an increase in endothelial nitric oxide. Beside the involvement of the endothelial nitric oxide pathway, the vascular response of trained/stressed rats involved an additional mechanism yet to be elucidated. These findings advance on the understanding of the vascular processes after exercise and stress alone and in combination.
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spelling Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoidsVasodilator prostanoidsNitric oxideExercise trainingAcute stressAorta reactivityPhysical therapyBackground: Physical exercise may modify biologic stress responses. Objective: To investigate the impact of exercise training on vascular alterations induced by acute stress, focusing on nitric oxide and cyclooxygenase pathways. Method: Wistar rats were separated into: sedentary, trained (60-min swimming, 5 days/week during 8 weeks, carrying a 5% body-weight load), stressed (2 h-immobilization), and trained/stressed. Response curves for noradrenaline, in the absence and presence of L-NAME or indomethacin, were obtained in intact and denuded aortas (n=7-10). Results: None of the procedures altered the denuded aorta reactivity. Intact aortas from stressed, trained, and trained/stressed rats showed similar reduction in noradrenaline maximal responses (sedentary 3.54±0.15, stressed 2.80±0.10*, trained 2.82±0.11*, trained/stressed 2.97± 0.21*, *P<0.05 relate to sedentary). Endothelium removal and L-NAME abolished this hyporeactivity in all experimental groups, except in trained/stressed rats that showed a partial aorta reactivity recovery in L-NAME presence (L-NAME: sedentary 5.23±0,26#, stressed 5.55±0.38#, trained 5.28±0.30#, trained/stressed 4.42±0.41, #P<0.05 related to trained/stressed). Indomethacin determined a decrease in sensitivity (EC50) in intact aortas of trained rats without abolishing the aortal hyporeactivity in trained, stressed, and trained/stressed rats. Conclusions: Exercise-induced vascular adaptive response involved an increase in endothelial vasodilator prostaglandins and nitric oxide. Stress-induced vascular adaptive response involved an increase in endothelial nitric oxide. Beside the involvement of the endothelial nitric oxide pathway, the vascular response of trained/stressed rats involved an additional mechanism yet to be elucidated. These findings advance on the understanding of the vascular processes after exercise and stress alone and in combination.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual Paulista Instituto de Biociências Departamento de FarmacologiaUNESP Faculdade de Ciências Agronômicas Departamento de Proteção VegetalUniversidade Estadual de Campinas Faculdade de Ciências MédicasUniversidade Estadual Paulista Instituto de Biociências Departamento de FarmacologiaUNESP Faculdade de Ciências Agronômicas Departamento de Proteção VegetalFAPESP: 2006/57200-8Associação Brasileira de Pesquisa e Pós-Graduação em FisioterapiaUniversidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Bruder-Nascimento, Thiago [UNESP]Silva, Samuel T. [UNESP]Boer, Patrícia A.Cordellini, Sandra [UNESP]2015-08-26T19:21:59Z2015-08-26T19:21:59Z2015-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article177-185application/pdfhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-35552015000300177&lng=en&nrm=iso&tlng=enBrazilian Journal of Physical Therapy, v. 19, n. 3, p. 177-185, 2015.1413-3555http://hdl.handle.net/11449/12747110.1590/bjpt-rbf.2014.0088S1413-35552015000300177S1413-35552015000300177.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Physical Therapy1.6990,802info:eu-repo/semantics/openAccess2024-04-30T18:06:49Zoai:repositorio.unesp.br:11449/127471Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:15:46.275349Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
title Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
spellingShingle Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
Bruder-Nascimento, Thiago [UNESP]
Vasodilator prostanoids
Nitric oxide
Exercise training
Acute stress
Aorta reactivity
Physical therapy
title_short Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
title_full Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
title_fullStr Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
title_full_unstemmed Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
title_sort Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
author Bruder-Nascimento, Thiago [UNESP]
author_facet Bruder-Nascimento, Thiago [UNESP]
Silva, Samuel T. [UNESP]
Boer, Patrícia A.
Cordellini, Sandra [UNESP]
author_role author
author2 Silva, Samuel T. [UNESP]
Boer, Patrícia A.
Cordellini, Sandra [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Estadual de Campinas (UNICAMP)
dc.contributor.author.fl_str_mv Bruder-Nascimento, Thiago [UNESP]
Silva, Samuel T. [UNESP]
Boer, Patrícia A.
Cordellini, Sandra [UNESP]
dc.subject.por.fl_str_mv Vasodilator prostanoids
Nitric oxide
Exercise training
Acute stress
Aorta reactivity
Physical therapy
topic Vasodilator prostanoids
Nitric oxide
Exercise training
Acute stress
Aorta reactivity
Physical therapy
description Background: Physical exercise may modify biologic stress responses. Objective: To investigate the impact of exercise training on vascular alterations induced by acute stress, focusing on nitric oxide and cyclooxygenase pathways. Method: Wistar rats were separated into: sedentary, trained (60-min swimming, 5 days/week during 8 weeks, carrying a 5% body-weight load), stressed (2 h-immobilization), and trained/stressed. Response curves for noradrenaline, in the absence and presence of L-NAME or indomethacin, were obtained in intact and denuded aortas (n=7-10). Results: None of the procedures altered the denuded aorta reactivity. Intact aortas from stressed, trained, and trained/stressed rats showed similar reduction in noradrenaline maximal responses (sedentary 3.54±0.15, stressed 2.80±0.10*, trained 2.82±0.11*, trained/stressed 2.97± 0.21*, *P<0.05 relate to sedentary). Endothelium removal and L-NAME abolished this hyporeactivity in all experimental groups, except in trained/stressed rats that showed a partial aorta reactivity recovery in L-NAME presence (L-NAME: sedentary 5.23±0,26#, stressed 5.55±0.38#, trained 5.28±0.30#, trained/stressed 4.42±0.41, #P<0.05 related to trained/stressed). Indomethacin determined a decrease in sensitivity (EC50) in intact aortas of trained rats without abolishing the aortal hyporeactivity in trained, stressed, and trained/stressed rats. Conclusions: Exercise-induced vascular adaptive response involved an increase in endothelial vasodilator prostaglandins and nitric oxide. Stress-induced vascular adaptive response involved an increase in endothelial nitric oxide. Beside the involvement of the endothelial nitric oxide pathway, the vascular response of trained/stressed rats involved an additional mechanism yet to be elucidated. These findings advance on the understanding of the vascular processes after exercise and stress alone and in combination.
publishDate 2015
dc.date.none.fl_str_mv 2015-08-26T19:21:59Z
2015-08-26T19:21:59Z
2015-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-35552015000300177&lng=en&nrm=iso&tlng=en
Brazilian Journal of Physical Therapy, v. 19, n. 3, p. 177-185, 2015.
1413-3555
http://hdl.handle.net/11449/127471
10.1590/bjpt-rbf.2014.0088
S1413-35552015000300177
S1413-35552015000300177.pdf
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-35552015000300177&lng=en&nrm=iso&tlng=en
http://hdl.handle.net/11449/127471
identifier_str_mv Brazilian Journal of Physical Therapy, v. 19, n. 3, p. 177-185, 2015.
1413-3555
10.1590/bjpt-rbf.2014.0088
S1413-35552015000300177
S1413-35552015000300177.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Physical Therapy
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 177-185
application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia
publisher.none.fl_str_mv Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia
dc.source.none.fl_str_mv SciELO
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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