Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-35552015000300177&lng=en&nrm=iso&tlng=en http://hdl.handle.net/11449/127471 |
Resumo: | Background: Physical exercise may modify biologic stress responses. Objective: To investigate the impact of exercise training on vascular alterations induced by acute stress, focusing on nitric oxide and cyclooxygenase pathways. Method: Wistar rats were separated into: sedentary, trained (60-min swimming, 5 days/week during 8 weeks, carrying a 5% body-weight load), stressed (2 h-immobilization), and trained/stressed. Response curves for noradrenaline, in the absence and presence of L-NAME or indomethacin, were obtained in intact and denuded aortas (n=7-10). Results: None of the procedures altered the denuded aorta reactivity. Intact aortas from stressed, trained, and trained/stressed rats showed similar reduction in noradrenaline maximal responses (sedentary 3.54±0.15, stressed 2.80±0.10*, trained 2.82±0.11*, trained/stressed 2.97± 0.21*, *P<0.05 relate to sedentary). Endothelium removal and L-NAME abolished this hyporeactivity in all experimental groups, except in trained/stressed rats that showed a partial aorta reactivity recovery in L-NAME presence (L-NAME: sedentary 5.23±0,26#, stressed 5.55±0.38#, trained 5.28±0.30#, trained/stressed 4.42±0.41, #P<0.05 related to trained/stressed). Indomethacin determined a decrease in sensitivity (EC50) in intact aortas of trained rats without abolishing the aortal hyporeactivity in trained, stressed, and trained/stressed rats. Conclusions: Exercise-induced vascular adaptive response involved an increase in endothelial vasodilator prostaglandins and nitric oxide. Stress-induced vascular adaptive response involved an increase in endothelial nitric oxide. Beside the involvement of the endothelial nitric oxide pathway, the vascular response of trained/stressed rats involved an additional mechanism yet to be elucidated. These findings advance on the understanding of the vascular processes after exercise and stress alone and in combination. |
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Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoidsVasodilator prostanoidsNitric oxideExercise trainingAcute stressAorta reactivityPhysical therapyBackground: Physical exercise may modify biologic stress responses. Objective: To investigate the impact of exercise training on vascular alterations induced by acute stress, focusing on nitric oxide and cyclooxygenase pathways. Method: Wistar rats were separated into: sedentary, trained (60-min swimming, 5 days/week during 8 weeks, carrying a 5% body-weight load), stressed (2 h-immobilization), and trained/stressed. Response curves for noradrenaline, in the absence and presence of L-NAME or indomethacin, were obtained in intact and denuded aortas (n=7-10). Results: None of the procedures altered the denuded aorta reactivity. Intact aortas from stressed, trained, and trained/stressed rats showed similar reduction in noradrenaline maximal responses (sedentary 3.54±0.15, stressed 2.80±0.10*, trained 2.82±0.11*, trained/stressed 2.97± 0.21*, *P<0.05 relate to sedentary). Endothelium removal and L-NAME abolished this hyporeactivity in all experimental groups, except in trained/stressed rats that showed a partial aorta reactivity recovery in L-NAME presence (L-NAME: sedentary 5.23±0,26#, stressed 5.55±0.38#, trained 5.28±0.30#, trained/stressed 4.42±0.41, #P<0.05 related to trained/stressed). Indomethacin determined a decrease in sensitivity (EC50) in intact aortas of trained rats without abolishing the aortal hyporeactivity in trained, stressed, and trained/stressed rats. Conclusions: Exercise-induced vascular adaptive response involved an increase in endothelial vasodilator prostaglandins and nitric oxide. Stress-induced vascular adaptive response involved an increase in endothelial nitric oxide. Beside the involvement of the endothelial nitric oxide pathway, the vascular response of trained/stressed rats involved an additional mechanism yet to be elucidated. These findings advance on the understanding of the vascular processes after exercise and stress alone and in combination.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Estadual Paulista Instituto de Biociências Departamento de FarmacologiaUNESP Faculdade de Ciências Agronômicas Departamento de Proteção VegetalUniversidade Estadual de Campinas Faculdade de Ciências MédicasUniversidade Estadual Paulista Instituto de Biociências Departamento de FarmacologiaUNESP Faculdade de Ciências Agronômicas Departamento de Proteção VegetalFAPESP: 2006/57200-8Associação Brasileira de Pesquisa e Pós-Graduação em FisioterapiaUniversidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)Bruder-Nascimento, Thiago [UNESP]Silva, Samuel T. [UNESP]Boer, Patrícia A.Cordellini, Sandra [UNESP]2015-08-26T19:21:59Z2015-08-26T19:21:59Z2015-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article177-185application/pdfhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-35552015000300177&lng=en&nrm=iso&tlng=enBrazilian Journal of Physical Therapy, v. 19, n. 3, p. 177-185, 2015.1413-3555http://hdl.handle.net/11449/12747110.1590/bjpt-rbf.2014.0088S1413-35552015000300177S1413-35552015000300177.pdfSciELOreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Physical Therapy1.6990,802info:eu-repo/semantics/openAccess2024-04-30T18:06:49Zoai:repositorio.unesp.br:11449/127471Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:15:46.275349Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids |
title |
Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids |
spellingShingle |
Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids Bruder-Nascimento, Thiago [UNESP] Vasodilator prostanoids Nitric oxide Exercise training Acute stress Aorta reactivity Physical therapy |
title_short |
Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids |
title_full |
Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids |
title_fullStr |
Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids |
title_full_unstemmed |
Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids |
title_sort |
Effects of exercise training on stress-induced vascular reactivity alterations: role of nitric oxide and prostanoids |
author |
Bruder-Nascimento, Thiago [UNESP] |
author_facet |
Bruder-Nascimento, Thiago [UNESP] Silva, Samuel T. [UNESP] Boer, Patrícia A. Cordellini, Sandra [UNESP] |
author_role |
author |
author2 |
Silva, Samuel T. [UNESP] Boer, Patrícia A. Cordellini, Sandra [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
Bruder-Nascimento, Thiago [UNESP] Silva, Samuel T. [UNESP] Boer, Patrícia A. Cordellini, Sandra [UNESP] |
dc.subject.por.fl_str_mv |
Vasodilator prostanoids Nitric oxide Exercise training Acute stress Aorta reactivity Physical therapy |
topic |
Vasodilator prostanoids Nitric oxide Exercise training Acute stress Aorta reactivity Physical therapy |
description |
Background: Physical exercise may modify biologic stress responses. Objective: To investigate the impact of exercise training on vascular alterations induced by acute stress, focusing on nitric oxide and cyclooxygenase pathways. Method: Wistar rats were separated into: sedentary, trained (60-min swimming, 5 days/week during 8 weeks, carrying a 5% body-weight load), stressed (2 h-immobilization), and trained/stressed. Response curves for noradrenaline, in the absence and presence of L-NAME or indomethacin, were obtained in intact and denuded aortas (n=7-10). Results: None of the procedures altered the denuded aorta reactivity. Intact aortas from stressed, trained, and trained/stressed rats showed similar reduction in noradrenaline maximal responses (sedentary 3.54±0.15, stressed 2.80±0.10*, trained 2.82±0.11*, trained/stressed 2.97± 0.21*, *P<0.05 relate to sedentary). Endothelium removal and L-NAME abolished this hyporeactivity in all experimental groups, except in trained/stressed rats that showed a partial aorta reactivity recovery in L-NAME presence (L-NAME: sedentary 5.23±0,26#, stressed 5.55±0.38#, trained 5.28±0.30#, trained/stressed 4.42±0.41, #P<0.05 related to trained/stressed). Indomethacin determined a decrease in sensitivity (EC50) in intact aortas of trained rats without abolishing the aortal hyporeactivity in trained, stressed, and trained/stressed rats. Conclusions: Exercise-induced vascular adaptive response involved an increase in endothelial vasodilator prostaglandins and nitric oxide. Stress-induced vascular adaptive response involved an increase in endothelial nitric oxide. Beside the involvement of the endothelial nitric oxide pathway, the vascular response of trained/stressed rats involved an additional mechanism yet to be elucidated. These findings advance on the understanding of the vascular processes after exercise and stress alone and in combination. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08-26T19:21:59Z 2015-08-26T19:21:59Z 2015-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-35552015000300177&lng=en&nrm=iso&tlng=en Brazilian Journal of Physical Therapy, v. 19, n. 3, p. 177-185, 2015. 1413-3555 http://hdl.handle.net/11449/127471 10.1590/bjpt-rbf.2014.0088 S1413-35552015000300177 S1413-35552015000300177.pdf |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-35552015000300177&lng=en&nrm=iso&tlng=en http://hdl.handle.net/11449/127471 |
identifier_str_mv |
Brazilian Journal of Physical Therapy, v. 19, n. 3, p. 177-185, 2015. 1413-3555 10.1590/bjpt-rbf.2014.0088 S1413-35552015000300177 S1413-35552015000300177.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Physical Therapy 1.699 0,802 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
177-185 application/pdf |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia |
publisher.none.fl_str_mv |
Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia |
dc.source.none.fl_str_mv |
SciELO reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128337330044928 |