Ascorbic acid in the prevention and treatment of cancer

Detalhes bibliográficos
Autor(a) principal: Mata,Ana Maria Oliveira Ferreira da
Data de Publicação: 2016
Outros Autores: Carvalho,Ricardo Melo de, Alencar,Marcus Vinícius Oliveira Barros de, Cavalcante,Ana Amélia de Carvalho Melo, Silva,Benedito Borges da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Associação Médica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016000700680
Resumo: Summary This review is aimed at the systematic mapping of ascorbic acid in the prevention and/or treatment of cancer in clinical and non-clinical studies from 2011 to 2015, in order to understand dose-response variations as well as its mechanisms of action as an antioxidant and antitumor agent. Seventy-eight articles were retrieved from the PubMed/Bireme database, of which only 30 included ascorbic acid in the prevention and/or treatment of cancer. However, there are controversies regarding doses and a lack of clinical studies featuring its mechanism of action more clearly. Other studies are needed to understand dose-response variations, as well as its targeting mechanisms of action, both as an antioxidant and antitumor agent, to assist treatment and prevention of cancer, aiming at better quality of life for both patients and the general population.
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spelling Ascorbic acid in the prevention and treatment of cancerneoplasmscancerpreventionascorbic acidantioxidantsSummary This review is aimed at the systematic mapping of ascorbic acid in the prevention and/or treatment of cancer in clinical and non-clinical studies from 2011 to 2015, in order to understand dose-response variations as well as its mechanisms of action as an antioxidant and antitumor agent. Seventy-eight articles were retrieved from the PubMed/Bireme database, of which only 30 included ascorbic acid in the prevention and/or treatment of cancer. However, there are controversies regarding doses and a lack of clinical studies featuring its mechanism of action more clearly. Other studies are needed to understand dose-response variations, as well as its targeting mechanisms of action, both as an antioxidant and antitumor agent, to assist treatment and prevention of cancer, aiming at better quality of life for both patients and the general population.Associação Médica Brasileira2016-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016000700680Revista da Associação Médica Brasileira v.62 n.7 2016reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.62.07.680info:eu-repo/semantics/openAccessMata,Ana Maria Oliveira Ferreira daCarvalho,Ricardo Melo deAlencar,Marcus Vinícius Oliveira Barros deCavalcante,Ana Amélia de Carvalho MeloSilva,Benedito Borges daeng2016-12-01T00:00:00Zoai:scielo:S0104-42302016000700680Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2016-12-01T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false
dc.title.none.fl_str_mv Ascorbic acid in the prevention and treatment of cancer
title Ascorbic acid in the prevention and treatment of cancer
spellingShingle Ascorbic acid in the prevention and treatment of cancer
Mata,Ana Maria Oliveira Ferreira da
neoplasms
cancer
prevention
ascorbic acid
antioxidants
title_short Ascorbic acid in the prevention and treatment of cancer
title_full Ascorbic acid in the prevention and treatment of cancer
title_fullStr Ascorbic acid in the prevention and treatment of cancer
title_full_unstemmed Ascorbic acid in the prevention and treatment of cancer
title_sort Ascorbic acid in the prevention and treatment of cancer
author Mata,Ana Maria Oliveira Ferreira da
author_facet Mata,Ana Maria Oliveira Ferreira da
Carvalho,Ricardo Melo de
Alencar,Marcus Vinícius Oliveira Barros de
Cavalcante,Ana Amélia de Carvalho Melo
Silva,Benedito Borges da
author_role author
author2 Carvalho,Ricardo Melo de
Alencar,Marcus Vinícius Oliveira Barros de
Cavalcante,Ana Amélia de Carvalho Melo
Silva,Benedito Borges da
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Mata,Ana Maria Oliveira Ferreira da
Carvalho,Ricardo Melo de
Alencar,Marcus Vinícius Oliveira Barros de
Cavalcante,Ana Amélia de Carvalho Melo
Silva,Benedito Borges da
dc.subject.por.fl_str_mv neoplasms
cancer
prevention
ascorbic acid
antioxidants
topic neoplasms
cancer
prevention
ascorbic acid
antioxidants
description Summary This review is aimed at the systematic mapping of ascorbic acid in the prevention and/or treatment of cancer in clinical and non-clinical studies from 2011 to 2015, in order to understand dose-response variations as well as its mechanisms of action as an antioxidant and antitumor agent. Seventy-eight articles were retrieved from the PubMed/Bireme database, of which only 30 included ascorbic acid in the prevention and/or treatment of cancer. However, there are controversies regarding doses and a lack of clinical studies featuring its mechanism of action more clearly. Other studies are needed to understand dose-response variations, as well as its targeting mechanisms of action, both as an antioxidant and antitumor agent, to assist treatment and prevention of cancer, aiming at better quality of life for both patients and the general population.
publishDate 2016
dc.date.none.fl_str_mv 2016-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016000700680
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016000700680
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1806-9282.62.07.680
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Médica Brasileira
publisher.none.fl_str_mv Associação Médica Brasileira
dc.source.none.fl_str_mv Revista da Associação Médica Brasileira v.62 n.7 2016
reponame:Revista da Associação Médica Brasileira (Online)
instname:Associação Médica Brasileira (AMB)
instacron:AMB
instname_str Associação Médica Brasileira (AMB)
instacron_str AMB
institution AMB
reponame_str Revista da Associação Médica Brasileira (Online)
collection Revista da Associação Médica Brasileira (Online)
repository.name.fl_str_mv Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)
repository.mail.fl_str_mv ||ramb@amb.org.br
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