The effect of deep brain stimulation on motor and cognitive symptoms of Parkinson's disease: A literature review

Detalhes bibliográficos
Autor(a) principal: Machado,Flavia Amaral
Data de Publicação: 2015
Outros Autores: Reppold,Caroline Tozzi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Dementia & Neuropsychologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642015000100024
Resumo: Deep brain stimulator (DBS) implant surgery is considered a breakthrough in the treatment of Parkinson's disease, especially in cases where motor symptoms cannot be controlled through conventional drug treatment. Its benefits have been studied extensively in the literature, particularly in relation to motor symptoms. However, the disease's cognitive aspects have been studied to a lesser extent. OBJECTIVE: This systematic review aims to assess the effects of DBS surgery on motor and cognitive symptoms in patients with Parkinson's disease. METHODS: The search strategy included MEDLINE, LILACs, SCIELO and the Cochrane Library. Randomized clinical trials with DBS surgical intervention and Parkinson's disease were included. Of the 178 studies identified, 19 met the eligibility criteria. These studies were descriptively analyzed as regards to their results. RESULTS: Control of motor symptoms, as assessed by the UPDRS Part III scale, was found in all of the studies, pointing to great interest in this outcome and demonstrating an advantage of DBS over conventional drug treatment. Regarding cognitive aspects, heterogeneity in the choice of subjects studied and the use of different assessment tools for each was evident, hampering comparisons and leading to inconclusive results. CONCLUSION: This review provides a broad overview of the effects of DBS on Parkinson's disease symptoms. However, it is suggested that future studies be conducted to establish a gold-standard protocol for neuropsychological assessment, thereby enabling data comparison and more consistent conclusions.
id ANCC-1_856081acfb9f23c3380f67edf0260567
oai_identifier_str oai:scielo:S1980-57642015000100024
network_acronym_str ANCC-1
network_name_str Dementia & Neuropsychologia
repository_id_str
spelling The effect of deep brain stimulation on motor and cognitive symptoms of Parkinson's disease: A literature reviewParkinson's diseasedeep brain stimulation (DBS)cognitionmotor symptomsDeep brain stimulator (DBS) implant surgery is considered a breakthrough in the treatment of Parkinson's disease, especially in cases where motor symptoms cannot be controlled through conventional drug treatment. Its benefits have been studied extensively in the literature, particularly in relation to motor symptoms. However, the disease's cognitive aspects have been studied to a lesser extent. OBJECTIVE: This systematic review aims to assess the effects of DBS surgery on motor and cognitive symptoms in patients with Parkinson's disease. METHODS: The search strategy included MEDLINE, LILACs, SCIELO and the Cochrane Library. Randomized clinical trials with DBS surgical intervention and Parkinson's disease were included. Of the 178 studies identified, 19 met the eligibility criteria. These studies were descriptively analyzed as regards to their results. RESULTS: Control of motor symptoms, as assessed by the UPDRS Part III scale, was found in all of the studies, pointing to great interest in this outcome and demonstrating an advantage of DBS over conventional drug treatment. Regarding cognitive aspects, heterogeneity in the choice of subjects studied and the use of different assessment tools for each was evident, hampering comparisons and leading to inconclusive results. CONCLUSION: This review provides a broad overview of the effects of DBS on Parkinson's disease symptoms. However, it is suggested that future studies be conducted to establish a gold-standard protocol for neuropsychological assessment, thereby enabling data comparison and more consistent conclusions. Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2015-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642015000100024Dementia & Neuropsychologia v.9 n.1 2015reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/S1980-57642015DN91000005info:eu-repo/semantics/openAccessMachado,Flavia AmaralReppold,Caroline Tozzieng2015-05-26T00:00:00Zoai:scielo:S1980-57642015000100024Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2015-05-26T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false
dc.title.none.fl_str_mv The effect of deep brain stimulation on motor and cognitive symptoms of Parkinson's disease: A literature review
title The effect of deep brain stimulation on motor and cognitive symptoms of Parkinson's disease: A literature review
spellingShingle The effect of deep brain stimulation on motor and cognitive symptoms of Parkinson's disease: A literature review
Machado,Flavia Amaral
Parkinson's disease
deep brain stimulation (DBS)
cognition
motor symptoms
title_short The effect of deep brain stimulation on motor and cognitive symptoms of Parkinson's disease: A literature review
title_full The effect of deep brain stimulation on motor and cognitive symptoms of Parkinson's disease: A literature review
title_fullStr The effect of deep brain stimulation on motor and cognitive symptoms of Parkinson's disease: A literature review
title_full_unstemmed The effect of deep brain stimulation on motor and cognitive symptoms of Parkinson's disease: A literature review
title_sort The effect of deep brain stimulation on motor and cognitive symptoms of Parkinson's disease: A literature review
author Machado,Flavia Amaral
author_facet Machado,Flavia Amaral
Reppold,Caroline Tozzi
author_role author
author2 Reppold,Caroline Tozzi
author2_role author
dc.contributor.author.fl_str_mv Machado,Flavia Amaral
Reppold,Caroline Tozzi
dc.subject.por.fl_str_mv Parkinson's disease
deep brain stimulation (DBS)
cognition
motor symptoms
topic Parkinson's disease
deep brain stimulation (DBS)
cognition
motor symptoms
description Deep brain stimulator (DBS) implant surgery is considered a breakthrough in the treatment of Parkinson's disease, especially in cases where motor symptoms cannot be controlled through conventional drug treatment. Its benefits have been studied extensively in the literature, particularly in relation to motor symptoms. However, the disease's cognitive aspects have been studied to a lesser extent. OBJECTIVE: This systematic review aims to assess the effects of DBS surgery on motor and cognitive symptoms in patients with Parkinson's disease. METHODS: The search strategy included MEDLINE, LILACs, SCIELO and the Cochrane Library. Randomized clinical trials with DBS surgical intervention and Parkinson's disease were included. Of the 178 studies identified, 19 met the eligibility criteria. These studies were descriptively analyzed as regards to their results. RESULTS: Control of motor symptoms, as assessed by the UPDRS Part III scale, was found in all of the studies, pointing to great interest in this outcome and demonstrating an advantage of DBS over conventional drug treatment. Regarding cognitive aspects, heterogeneity in the choice of subjects studied and the use of different assessment tools for each was evident, hampering comparisons and leading to inconclusive results. CONCLUSION: This review provides a broad overview of the effects of DBS on Parkinson's disease symptoms. However, it is suggested that future studies be conducted to establish a gold-standard protocol for neuropsychological assessment, thereby enabling data comparison and more consistent conclusions.
publishDate 2015
dc.date.none.fl_str_mv 2015-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642015000100024
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642015000100024
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1980-57642015DN91000005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
dc.source.none.fl_str_mv Dementia & Neuropsychologia v.9 n.1 2015
reponame:Dementia & Neuropsychologia
instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron:ANCC
instname_str Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron_str ANCC
institution ANCC
reponame_str Dementia & Neuropsychologia
collection Dementia & Neuropsychologia
repository.name.fl_str_mv Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)
repository.mail.fl_str_mv ||demneuropsy@uol.com.br
_version_ 1754212931027861504