Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study

Detalhes bibliográficos
Autor(a) principal: Kraychete,Durval Campos
Data de Publicação: 2010
Outros Autores: Sakata,Rioko Kimiko, Issy,Adriana Machado, Bacellar,Olívia, Santos-Jesus,Rogério, Carvalho,Edgar Marcelino
Tipo de documento: Artigo
Idioma: eng
Título da fonte: São Paulo medical journal (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802010000500003
Resumo: CONTEXT AND OBJECTIVE: The role of immune response and proinflammatory cytokines in the pathogenesis of chronic pain has been of growing interest. In order to evaluate whether there is any association between disc herniation and elevated cytokine levels, we measured cytokine levels in patients with chronic low back pain and in healthy subjects. DESIGN AND SETTING: Analytical cross-sectional study at the Pain Clinic of Universidade Federal da Bahia (UFBA). METHODS: Cytokine levels were measured using the enzyme-linked immunosorbent assay (ELISA) technique on 23 patients with low back pain (G1) and on 10 healthy subjects (G2). RESULTS: The levels of tumor necrosis factor-alpha [TNF-alpha] (G1 = 5.6 ± 2.3 pg/ml; G2 = 1.6 ± 0.5 pg/ml; P = 0.01) and interleukin-6 [IL-6] (G1 = 4.1 ± 3.0 pg/ml; G2 = 0.9 ± 0.4 pg/ml; P = 0.01) were higher in G1. There were no statistically significant differences in relation to interleukin-1 [IL-1] (G1 = 0.5 ± 0.3 pg/ml; G2 = 0.5 ± 0.1 pg/ml; P = 1) or soluble tumor necrosis factor receptor [sTNF-R] (G1 = 572 pg/ml ± 36; G2 = 581 ± 50 pg/ml; P = 0.87). CONCLUSION: The patients with chronic low back pain due to disc herniation presented higher levels of TNF-alpha and IL-6, but not of IL-1 or sTNF-R.
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spelling Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional studyCytokinesLow back painTumor necrosis factor-alphaInterleukinsInterleukin-6CONTEXT AND OBJECTIVE: The role of immune response and proinflammatory cytokines in the pathogenesis of chronic pain has been of growing interest. In order to evaluate whether there is any association between disc herniation and elevated cytokine levels, we measured cytokine levels in patients with chronic low back pain and in healthy subjects. DESIGN AND SETTING: Analytical cross-sectional study at the Pain Clinic of Universidade Federal da Bahia (UFBA). METHODS: Cytokine levels were measured using the enzyme-linked immunosorbent assay (ELISA) technique on 23 patients with low back pain (G1) and on 10 healthy subjects (G2). RESULTS: The levels of tumor necrosis factor-alpha [TNF-alpha] (G1 = 5.6 ± 2.3 pg/ml; G2 = 1.6 ± 0.5 pg/ml; P = 0.01) and interleukin-6 [IL-6] (G1 = 4.1 ± 3.0 pg/ml; G2 = 0.9 ± 0.4 pg/ml; P = 0.01) were higher in G1. There were no statistically significant differences in relation to interleukin-1 [IL-1] (G1 = 0.5 ± 0.3 pg/ml; G2 = 0.5 ± 0.1 pg/ml; P = 1) or soluble tumor necrosis factor receptor [sTNF-R] (G1 = 572 pg/ml ± 36; G2 = 581 ± 50 pg/ml; P = 0.87). CONCLUSION: The patients with chronic low back pain due to disc herniation presented higher levels of TNF-alpha and IL-6, but not of IL-1 or sTNF-R.Associação Paulista de Medicina - APM2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802010000500003Sao Paulo Medical Journal v.128 n.5 2010reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31802010000500003info:eu-repo/semantics/openAccessKraychete,Durval CamposSakata,Rioko KimikoIssy,Adriana MachadoBacellar,OlíviaSantos-Jesus,RogérioCarvalho,Edgar Marcelinoeng2010-12-16T00:00:00Zoai:scielo:S1516-31802010000500003Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2010-12-16T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study
title Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study
spellingShingle Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study
Kraychete,Durval Campos
Cytokines
Low back pain
Tumor necrosis factor-alpha
Interleukins
Interleukin-6
title_short Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study
title_full Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study
title_fullStr Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study
title_full_unstemmed Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study
title_sort Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study
author Kraychete,Durval Campos
author_facet Kraychete,Durval Campos
Sakata,Rioko Kimiko
Issy,Adriana Machado
Bacellar,Olívia
Santos-Jesus,Rogério
Carvalho,Edgar Marcelino
author_role author
author2 Sakata,Rioko Kimiko
Issy,Adriana Machado
Bacellar,Olívia
Santos-Jesus,Rogério
Carvalho,Edgar Marcelino
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Kraychete,Durval Campos
Sakata,Rioko Kimiko
Issy,Adriana Machado
Bacellar,Olívia
Santos-Jesus,Rogério
Carvalho,Edgar Marcelino
dc.subject.por.fl_str_mv Cytokines
Low back pain
Tumor necrosis factor-alpha
Interleukins
Interleukin-6
topic Cytokines
Low back pain
Tumor necrosis factor-alpha
Interleukins
Interleukin-6
description CONTEXT AND OBJECTIVE: The role of immune response and proinflammatory cytokines in the pathogenesis of chronic pain has been of growing interest. In order to evaluate whether there is any association between disc herniation and elevated cytokine levels, we measured cytokine levels in patients with chronic low back pain and in healthy subjects. DESIGN AND SETTING: Analytical cross-sectional study at the Pain Clinic of Universidade Federal da Bahia (UFBA). METHODS: Cytokine levels were measured using the enzyme-linked immunosorbent assay (ELISA) technique on 23 patients with low back pain (G1) and on 10 healthy subjects (G2). RESULTS: The levels of tumor necrosis factor-alpha [TNF-alpha] (G1 = 5.6 ± 2.3 pg/ml; G2 = 1.6 ± 0.5 pg/ml; P = 0.01) and interleukin-6 [IL-6] (G1 = 4.1 ± 3.0 pg/ml; G2 = 0.9 ± 0.4 pg/ml; P = 0.01) were higher in G1. There were no statistically significant differences in relation to interleukin-1 [IL-1] (G1 = 0.5 ± 0.3 pg/ml; G2 = 0.5 ± 0.1 pg/ml; P = 1) or soluble tumor necrosis factor receptor [sTNF-R] (G1 = 572 pg/ml ± 36; G2 = 581 ± 50 pg/ml; P = 0.87). CONCLUSION: The patients with chronic low back pain due to disc herniation presented higher levels of TNF-alpha and IL-6, but not of IL-1 or sTNF-R.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802010000500003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802010000500003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-31802010000500003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv Sao Paulo Medical Journal v.128 n.5 2010
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
instacron_str APM
institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
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