Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/5614 |
Resumo: | Acesso restrito: Texto completo. p. 259-262. |
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Kraychete, Durval CamposSakata, Rioko KimikoIssy, Adriana MachadoBacellar, Maria Olívia Amado RamosJesus, Rogério SantosCarvalho Filho, Edgar Marcelino deKraychete, Durval CamposSakata, Rioko KimikoIssy, Adriana MachadoBacellar, Maria Olívia Amado RamosJesus, Rogério SantosCarvalho Filho, Edgar Marcelino de2012-04-13T11:50:47Z20101516-3180http://www.repositorio.ufba.br/ri/handle/ri/5614v. 128, n. 5.Acesso restrito: Texto completo. p. 259-262.CONTEXT AND OBJECTIVE: The role of immune response and proinflammatory cytokines in the pathogenesis of chronic pain has been of growing interest. In order to evaluate whether there is any association between disc herniation and elevated cytokine levels, we measured cytokine levels in patients with chronic low back pain and in healthy subjects. DESIGN AND SETTING: Analytical cross-sectional study at the Pain Clinic of Universidade Federal da Bahia (UFBA). METHODS: Cytokine levels were measured using the enzyme-linked immunosorbent assay (ELISA) technique on 23 patients with low back pain (G1) and on 10 healthy subjects (G2). RESULTS: The levels of tumor necrosis factor-alpha [TNF-alpha] (G1 = 5.6 ± 2.3 pg/ml; G2 = 1.6 ± 0.5 pg/ml; P = 0.01) and interleukin-6 [IL-6] (G1 = 4.1 ± 3.0 pg/ml; G2 = 0.9 ± 0.4 pg/ml; P = 0.01) were higher in G1. There were no statistically significant differences in relation to interleukin-1 [IL-1] (G1 = 0.5 ± 0.3 pg/ml; G2 = 0.5 ± 0.1 pg/ml; P = 1) or soluble tumor necrosis factor receptor [sTNF-R] (G1 = 572 pg/ml ± 36; G2 = 581 ± 50 pg/ml; P = 0.87). CONCLUSION: The patients with chronic low back pain due to disc herniation presented higher levels of TNF-alpha and IL-6, but not of IL-1 or sTNF-R.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-04-13T11:50:47Z No. of bitstreams: 1 __www.scielo.br_pdf_spmj_v128n5_a03v1285.pdf: 118374 bytes, checksum: dcbb4e568ec8c3cf693555106f1ab1f4 (MD5)Made available in DSpace on 2012-04-13T11:50:47Z (GMT). No. of bitstreams: 1 __www.scielo.br_pdf_spmj_v128n5_a03v1285.pdf: 118374 bytes, checksum: dcbb4e568ec8c3cf693555106f1ab1f4 (MD5) Previous issue date: 2010São PauloDOI: 10.1590/S1516-31802010000500003reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACytokinesLow back painTumor necrosis factor-alphaInterleukinsInterleukin-6Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional studySão Paulo Medical Journalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL__www.scielo.br_pdf_spmj_v128n5_a03v1285.pdf__www.scielo.br_pdf_spmj_v128n5_a03v1285.pdfapplication/pdf118374https://repositorio.ufba.br/bitstream/ri/5614/1/__www.scielo.br_pdf_spmj_v128n5_a03v1285.pdfdcbb4e568ec8c3cf693555106f1ab1f4MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5614/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT__www.scielo.br_pdf_spmj_v128n5_a03v1285.pdf.txt__www.scielo.br_pdf_spmj_v128n5_a03v1285.pdf.txtExtracted texttext/plain23523https://repositorio.ufba.br/bitstream/ri/5614/3/__www.scielo.br_pdf_spmj_v128n5_a03v1285.pdf.txtd8cb53810d43b50351dffd5c424ae2a5MD53ri/56142022-07-05 14:03:13.342oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:13Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study |
| dc.title.alternative.pt_BR.fl_str_mv |
São Paulo Medical Journal |
| title |
Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study |
| spellingShingle |
Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study Kraychete, Durval Campos Cytokines Low back pain Tumor necrosis factor-alpha Interleukins Interleukin-6 |
| title_short |
Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study |
| title_full |
Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study |
| title_fullStr |
Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study |
| title_full_unstemmed |
Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study |
| title_sort |
Serum cytokine levels in patients with chronic low back pain due to herniated disc: analytical cross-sectional study |
| author |
Kraychete, Durval Campos |
| author_facet |
Kraychete, Durval Campos Sakata, Rioko Kimiko Issy, Adriana Machado Bacellar, Maria Olívia Amado Ramos Jesus, Rogério Santos Carvalho Filho, Edgar Marcelino de |
| author_role |
author |
| author2 |
Sakata, Rioko Kimiko Issy, Adriana Machado Bacellar, Maria Olívia Amado Ramos Jesus, Rogério Santos Carvalho Filho, Edgar Marcelino de |
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author author author author author |
| dc.contributor.author.fl_str_mv |
Kraychete, Durval Campos Sakata, Rioko Kimiko Issy, Adriana Machado Bacellar, Maria Olívia Amado Ramos Jesus, Rogério Santos Carvalho Filho, Edgar Marcelino de Kraychete, Durval Campos Sakata, Rioko Kimiko Issy, Adriana Machado Bacellar, Maria Olívia Amado Ramos Jesus, Rogério Santos Carvalho Filho, Edgar Marcelino de |
| dc.subject.por.fl_str_mv |
Cytokines Low back pain Tumor necrosis factor-alpha Interleukins Interleukin-6 |
| topic |
Cytokines Low back pain Tumor necrosis factor-alpha Interleukins Interleukin-6 |
| description |
Acesso restrito: Texto completo. p. 259-262. |
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2010 |
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2010 |
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2012-04-13T11:50:47Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://www.repositorio.ufba.br/ri/handle/ri/5614 |
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1516-3180 |
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v. 128, n. 5. |
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1516-3180 v. 128, n. 5. |
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http://www.repositorio.ufba.br/ri/handle/ri/5614 |
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eng |
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openAccess |
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DOI: 10.1590/S1516-31802010000500003 |
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