A study of the pharmacological actions of Dioclea grandiflora martius ex bentham

Detalhes bibliográficos
Autor(a) principal: Mattei,Rita
Data de Publicação: 1995
Outros Autores: Leite,José Roberto, Tufik,Sérgio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: São Paulo medical journal (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000100004
Resumo: Dioclea grandiflora Mart. ex Bent., known as Mucuna or Mucuna of stone, is a member of the Leguminosae family, popularly used for its possible effects on the Central Nervous System (CNS). Reports mention sedative, tonic, and also antiepileptic properties for this plant. In this paper a screening for CNS action was done with aqueous extracts of the seeds. This study was carried out using some animal models for the study of sedative, hypnotic, anxiolytic, anticonvulsivant and neuroleptic activity. The results showed that Dioclea grandiflora Mart. ex Bent. demonstrates the general profile of a CNS depressant drug. However, the extract did not exhibit any of the specific profiles tested. Moreover, the results suggest a possible toxicity stemming from the popular or folk use of this plant.
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spelling A study of the pharmacological actions of Dioclea grandiflora martius ex benthamDioclea grandifloraMucunaPharmacologic screeningDioclea grandiflora Mart. ex Bent., known as Mucuna or Mucuna of stone, is a member of the Leguminosae family, popularly used for its possible effects on the Central Nervous System (CNS). Reports mention sedative, tonic, and also antiepileptic properties for this plant. In this paper a screening for CNS action was done with aqueous extracts of the seeds. This study was carried out using some animal models for the study of sedative, hypnotic, anxiolytic, anticonvulsivant and neuroleptic activity. The results showed that Dioclea grandiflora Mart. ex Bent. demonstrates the general profile of a CNS depressant drug. However, the extract did not exhibit any of the specific profiles tested. Moreover, the results suggest a possible toxicity stemming from the popular or folk use of this plant.Associação Paulista de Medicina - APM1995-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000100004Sao Paulo Medical Journal v.113 n.1 1995reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31801995000100004info:eu-repo/semantics/openAccessMattei,RitaLeite,José RobertoTufik,Sérgioeng2009-06-03T00:00:00Zoai:scielo:S1516-31801995000100004Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2009-06-03T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv A study of the pharmacological actions of Dioclea grandiflora martius ex bentham
title A study of the pharmacological actions of Dioclea grandiflora martius ex bentham
spellingShingle A study of the pharmacological actions of Dioclea grandiflora martius ex bentham
Mattei,Rita
Dioclea grandiflora
Mucuna
Pharmacologic screening
title_short A study of the pharmacological actions of Dioclea grandiflora martius ex bentham
title_full A study of the pharmacological actions of Dioclea grandiflora martius ex bentham
title_fullStr A study of the pharmacological actions of Dioclea grandiflora martius ex bentham
title_full_unstemmed A study of the pharmacological actions of Dioclea grandiflora martius ex bentham
title_sort A study of the pharmacological actions of Dioclea grandiflora martius ex bentham
author Mattei,Rita
author_facet Mattei,Rita
Leite,José Roberto
Tufik,Sérgio
author_role author
author2 Leite,José Roberto
Tufik,Sérgio
author2_role author
author
dc.contributor.author.fl_str_mv Mattei,Rita
Leite,José Roberto
Tufik,Sérgio
dc.subject.por.fl_str_mv Dioclea grandiflora
Mucuna
Pharmacologic screening
topic Dioclea grandiflora
Mucuna
Pharmacologic screening
description Dioclea grandiflora Mart. ex Bent., known as Mucuna or Mucuna of stone, is a member of the Leguminosae family, popularly used for its possible effects on the Central Nervous System (CNS). Reports mention sedative, tonic, and also antiepileptic properties for this plant. In this paper a screening for CNS action was done with aqueous extracts of the seeds. This study was carried out using some animal models for the study of sedative, hypnotic, anxiolytic, anticonvulsivant and neuroleptic activity. The results showed that Dioclea grandiflora Mart. ex Bent. demonstrates the general profile of a CNS depressant drug. However, the extract did not exhibit any of the specific profiles tested. Moreover, the results suggest a possible toxicity stemming from the popular or folk use of this plant.
publishDate 1995
dc.date.none.fl_str_mv 1995-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000100004
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801995000100004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-31801995000100004
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv Sao Paulo Medical Journal v.113 n.1 1995
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
instacron_str APM
institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
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