A study of the pharmacological actions of Dioclea grandiflora martius ex bentham

Detalhes bibliográficos
Autor(a) principal: Mattei, Rita [UNIFESP]
Data de Publicação: 1995
Outros Autores: Leite, Jose Roberto [UNIFESP], Tufik, Sergio [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1516-31801995000100004
http://repositorio.unifesp.br/handle/11600/365
Resumo: Dioclea grandiflora Mart. ex Bent., known as Mucuna or Mucuna of stone, is a member of the Leguminosae family, popularly used for its possible effects on the Central Nervous System (CNS). Reports mention sedative, tonic, and also antiepileptic properties for this plant. In this paper a screening for CNS action was done with aqueous extracts of the seeds. This study was carried out using some animal models for the study of sedative, hypnotic, anxiolytic, anticonvulsivant and neuroleptic activity. The results showed that Dioclea grandiflora Mart. ex Bent. demonstrates the general profile of a CNS depressant drug. However, the extract did not exhibit any of the specific profiles tested. Moreover, the results suggest a possible toxicity stemming from the popular or folk use of this plant.
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spelling A study of the pharmacological actions of Dioclea grandiflora martius ex benthamDioclea grandifloraMucunaPharmacologic screeningDioclea grandiflora Mart. ex Bent., known as Mucuna or Mucuna of stone, is a member of the Leguminosae family, popularly used for its possible effects on the Central Nervous System (CNS). Reports mention sedative, tonic, and also antiepileptic properties for this plant. In this paper a screening for CNS action was done with aqueous extracts of the seeds. This study was carried out using some animal models for the study of sedative, hypnotic, anxiolytic, anticonvulsivant and neuroleptic activity. The results showed that Dioclea grandiflora Mart. ex Bent. demonstrates the general profile of a CNS depressant drug. However, the extract did not exhibit any of the specific profiles tested. Moreover, the results suggest a possible toxicity stemming from the popular or folk use of this plant.OBJETIVO: A Dioclea grandiflora Mart. ex Bent., também conhecida como Mucunã ou Mucunã de caroço, é uma espécie da família Leguminosae que tem sido usada popularmente em decorrência de seus possíveis efeitos no SNC. Os relatos populares atribuem à planta ação tônica, calmante e possivelmente antiepiléptica. Com o objetivo de comprovar essas propriedades, procurou-se determinar com estudos em animais, em ações psicofarmacológicas utilizando-se para tanto, as sementes da planta. MATERIAL E MÉTODOS: Foram realizados testes preliminares: medida de atividade e coordenação motora, e avaliadas as ações anticonvulsivante, neuroléptica, ansiolítica e hipnótica. RESULTADOS E CONCLUSÃO: Os resultados sugerem que a Dioclea grandiflora Mart. ex Bent., possui um perfil de droga depressora, não apresentando entretanto, as ações psicofarmacológicas esperadas. Os nossos dados sugerem ainda, um possível efeito tóxico o que representa um sinal de alerta quanto ao uso popular.Escola Paulista de Medicina Departament of PsychobiologyUNIFESP, EPM, Departament of PsychobiologySciELOAssociação Paulista de Medicina - APMUniversidade Federal de São Paulo (UNIFESP)Mattei, Rita [UNIFESP]Leite, Jose Roberto [UNIFESP]Tufik, Sergio [UNIFESP]2015-06-14T13:24:27Z2015-06-14T13:24:27Z1995-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion687-692application/pdfhttp://dx.doi.org/10.1590/S1516-31801995000100004São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 113, n. 1, p. 687-692, 1995.10.1590/S1516-31801995000100004S1516-31801995000100004.pdf1516-3180S1516-31801995000100004http://repositorio.unifesp.br/handle/11600/365engSão Paulo Medical Journalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-06T06:11:39Zoai:repositorio.unifesp.br/:11600/365Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-06T06:11:39Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv A study of the pharmacological actions of Dioclea grandiflora martius ex bentham
title A study of the pharmacological actions of Dioclea grandiflora martius ex bentham
spellingShingle A study of the pharmacological actions of Dioclea grandiflora martius ex bentham
Mattei, Rita [UNIFESP]
Dioclea grandiflora
Mucuna
Pharmacologic screening
title_short A study of the pharmacological actions of Dioclea grandiflora martius ex bentham
title_full A study of the pharmacological actions of Dioclea grandiflora martius ex bentham
title_fullStr A study of the pharmacological actions of Dioclea grandiflora martius ex bentham
title_full_unstemmed A study of the pharmacological actions of Dioclea grandiflora martius ex bentham
title_sort A study of the pharmacological actions of Dioclea grandiflora martius ex bentham
author Mattei, Rita [UNIFESP]
author_facet Mattei, Rita [UNIFESP]
Leite, Jose Roberto [UNIFESP]
Tufik, Sergio [UNIFESP]
author_role author
author2 Leite, Jose Roberto [UNIFESP]
Tufik, Sergio [UNIFESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Mattei, Rita [UNIFESP]
Leite, Jose Roberto [UNIFESP]
Tufik, Sergio [UNIFESP]
dc.subject.por.fl_str_mv Dioclea grandiflora
Mucuna
Pharmacologic screening
topic Dioclea grandiflora
Mucuna
Pharmacologic screening
description Dioclea grandiflora Mart. ex Bent., known as Mucuna or Mucuna of stone, is a member of the Leguminosae family, popularly used for its possible effects on the Central Nervous System (CNS). Reports mention sedative, tonic, and also antiepileptic properties for this plant. In this paper a screening for CNS action was done with aqueous extracts of the seeds. This study was carried out using some animal models for the study of sedative, hypnotic, anxiolytic, anticonvulsivant and neuroleptic activity. The results showed that Dioclea grandiflora Mart. ex Bent. demonstrates the general profile of a CNS depressant drug. However, the extract did not exhibit any of the specific profiles tested. Moreover, the results suggest a possible toxicity stemming from the popular or folk use of this plant.
publishDate 1995
dc.date.none.fl_str_mv 1995-02-01
2015-06-14T13:24:27Z
2015-06-14T13:24:27Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1516-31801995000100004
São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 113, n. 1, p. 687-692, 1995.
10.1590/S1516-31801995000100004
S1516-31801995000100004.pdf
1516-3180
S1516-31801995000100004
http://repositorio.unifesp.br/handle/11600/365
url http://dx.doi.org/10.1590/S1516-31801995000100004
http://repositorio.unifesp.br/handle/11600/365
identifier_str_mv São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 113, n. 1, p. 687-692, 1995.
10.1590/S1516-31801995000100004
S1516-31801995000100004.pdf
1516-3180
S1516-31801995000100004
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv São Paulo Medical Journal
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 687-692
application/pdf
dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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