Evaluation of SARS-CoV-2 genomic architecture and its alteration pattern through ORF analysis/ Avaliação da arquitetura genômica do SARS-CoV-2 e seu padrão de alteração por meio de análise de ORF
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Health Review |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/31103 |
Resumo: | Members of the Coronaviridae family comprise four genera Alphacoronavirus and Betacoronavirus, which infect only mammals, and Gammacoronavirus and Deltacoronavirus infect birds and mammals. Since the end of 2019, humanity has witnessed the emergence of a new pandemic caused by a line of beta-coronavirus (SARS-CoV-2) responsible for causing a novel severe acute respiratory syndrome named coronavirus disease (COVID-19) affecting countries worldwide. In this context, this work aimed to investigate the main changes in SARS-CoV-2 genomic architecture through the time since the beginning of the infection using in silico analysis. A genomic database was built using complete and revised genomes from NCBI as well as analyzed through sequencing alignment and phylogenetic softwares. This study was able to show a change in the organizational pattern of the genome of the new coronavirus for the different regions studied, in addition to showing specific changes in the genomic sequence requiring further analysis of the collected genomes and may provide new evidence for the key protein changes like Spike protein. |
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Brazilian Journal of Health Review |
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Evaluation of SARS-CoV-2 genomic architecture and its alteration pattern through ORF analysis/ Avaliação da arquitetura genômica do SARS-CoV-2 e seu padrão de alteração por meio de análise de ORFSARS-CoV-2GenomeCOVID-19.Members of the Coronaviridae family comprise four genera Alphacoronavirus and Betacoronavirus, which infect only mammals, and Gammacoronavirus and Deltacoronavirus infect birds and mammals. Since the end of 2019, humanity has witnessed the emergence of a new pandemic caused by a line of beta-coronavirus (SARS-CoV-2) responsible for causing a novel severe acute respiratory syndrome named coronavirus disease (COVID-19) affecting countries worldwide. In this context, this work aimed to investigate the main changes in SARS-CoV-2 genomic architecture through the time since the beginning of the infection using in silico analysis. A genomic database was built using complete and revised genomes from NCBI as well as analyzed through sequencing alignment and phylogenetic softwares. This study was able to show a change in the organizational pattern of the genome of the new coronavirus for the different regions studied, in addition to showing specific changes in the genomic sequence requiring further analysis of the collected genomes and may provide new evidence for the key protein changes like Spike protein.Brazilian Journals Publicações de Periódicos e Editora Ltda.2021-06-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/3110310.34119/bjhrv4n3-236Brazilian Journal of Health Review; Vol. 4 No. 3 (2021); 12700-12709Brazilian Journal of Health Review; v. 4 n. 3 (2021); 12700-127092595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/31103/pdfCopyright (c) 2021 Brazilian Journal of Health Reviewinfo:eu-repo/semantics/openAccessSantos, Yago Queiroz dosCarelli, Gabriella Silva CamposVeras, Bruno Oliveira deFrança, Anderson Felipe Jácome deSantos, Elizeu Antunes dos2021-07-01T20:07:14Zoai:ojs2.ojs.brazilianjournals.com.br:article/31103Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2021-07-01T20:07:14Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false |
dc.title.none.fl_str_mv |
Evaluation of SARS-CoV-2 genomic architecture and its alteration pattern through ORF analysis/ Avaliação da arquitetura genômica do SARS-CoV-2 e seu padrão de alteração por meio de análise de ORF |
title |
Evaluation of SARS-CoV-2 genomic architecture and its alteration pattern through ORF analysis/ Avaliação da arquitetura genômica do SARS-CoV-2 e seu padrão de alteração por meio de análise de ORF |
spellingShingle |
Evaluation of SARS-CoV-2 genomic architecture and its alteration pattern through ORF analysis/ Avaliação da arquitetura genômica do SARS-CoV-2 e seu padrão de alteração por meio de análise de ORF Santos, Yago Queiroz dos SARS-CoV-2 Genome COVID-19. |
title_short |
Evaluation of SARS-CoV-2 genomic architecture and its alteration pattern through ORF analysis/ Avaliação da arquitetura genômica do SARS-CoV-2 e seu padrão de alteração por meio de análise de ORF |
title_full |
Evaluation of SARS-CoV-2 genomic architecture and its alteration pattern through ORF analysis/ Avaliação da arquitetura genômica do SARS-CoV-2 e seu padrão de alteração por meio de análise de ORF |
title_fullStr |
Evaluation of SARS-CoV-2 genomic architecture and its alteration pattern through ORF analysis/ Avaliação da arquitetura genômica do SARS-CoV-2 e seu padrão de alteração por meio de análise de ORF |
title_full_unstemmed |
Evaluation of SARS-CoV-2 genomic architecture and its alteration pattern through ORF analysis/ Avaliação da arquitetura genômica do SARS-CoV-2 e seu padrão de alteração por meio de análise de ORF |
title_sort |
Evaluation of SARS-CoV-2 genomic architecture and its alteration pattern through ORF analysis/ Avaliação da arquitetura genômica do SARS-CoV-2 e seu padrão de alteração por meio de análise de ORF |
author |
Santos, Yago Queiroz dos |
author_facet |
Santos, Yago Queiroz dos Carelli, Gabriella Silva Campos Veras, Bruno Oliveira de França, Anderson Felipe Jácome de Santos, Elizeu Antunes dos |
author_role |
author |
author2 |
Carelli, Gabriella Silva Campos Veras, Bruno Oliveira de França, Anderson Felipe Jácome de Santos, Elizeu Antunes dos |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Santos, Yago Queiroz dos Carelli, Gabriella Silva Campos Veras, Bruno Oliveira de França, Anderson Felipe Jácome de Santos, Elizeu Antunes dos |
dc.subject.por.fl_str_mv |
SARS-CoV-2 Genome COVID-19. |
topic |
SARS-CoV-2 Genome COVID-19. |
description |
Members of the Coronaviridae family comprise four genera Alphacoronavirus and Betacoronavirus, which infect only mammals, and Gammacoronavirus and Deltacoronavirus infect birds and mammals. Since the end of 2019, humanity has witnessed the emergence of a new pandemic caused by a line of beta-coronavirus (SARS-CoV-2) responsible for causing a novel severe acute respiratory syndrome named coronavirus disease (COVID-19) affecting countries worldwide. In this context, this work aimed to investigate the main changes in SARS-CoV-2 genomic architecture through the time since the beginning of the infection using in silico analysis. A genomic database was built using complete and revised genomes from NCBI as well as analyzed through sequencing alignment and phylogenetic softwares. This study was able to show a change in the organizational pattern of the genome of the new coronavirus for the different regions studied, in addition to showing specific changes in the genomic sequence requiring further analysis of the collected genomes and may provide new evidence for the key protein changes like Spike protein. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-10 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/31103 10.34119/bjhrv4n3-236 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/31103 |
identifier_str_mv |
10.34119/bjhrv4n3-236 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/31103/pdf |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Brazilian Journal of Health Review info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Brazilian Journal of Health Review |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Health Review; Vol. 4 No. 3 (2021); 12700-12709 Brazilian Journal of Health Review; v. 4 n. 3 (2021); 12700-12709 2595-6825 reponame:Brazilian Journal of Health Review instname:Federação das Indústrias do Estado do Paraná (FIEP) instacron:BJRH |
instname_str |
Federação das Indústrias do Estado do Paraná (FIEP) |
instacron_str |
BJRH |
institution |
BJRH |
reponame_str |
Brazilian Journal of Health Review |
collection |
Brazilian Journal of Health Review |
repository.name.fl_str_mv |
Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP) |
repository.mail.fl_str_mv |
|| brazilianjhr@gmail.com |
_version_ |
1797240063705219072 |