Cerebral lymphoma mimicking glioblastoma in an AIDS patient / Linfoma cerebral que imita o glioblastoma em um paciente com AIDS

• Autor(a) principal: Azevedo, Roberta Dantas
• Data de Publicação: 2022
• Outros Autores: Borella, Luiz Fernando Monte, Rogério, Fábio, Queiroz, Luciano de Souza, Reis, Fabiano
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Brazilian Journal of Health Review
• Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/46550
• topic: primary cutaneous lymphoma; dissemination to the central nervous system of cutaneous lymphoma; glioblastoma; magnetic resonance imaging.

A 42-year-old male, HIV (human immunodeficiency virus) positive for 13 years, but without use of antiviral therapy, presented weight loss of 6 kg and erythematous-purplish lesions in the right buttock. Biopsy was showed cutaneous diffuse large B-cell lymphoma.  The patient received antiretroviral therapy and six cycles of chemotherapy achieving complete remission.After 5 years, the patient presented progressive headache with an episode of loss of balance with fall and mental confusion. Brain magnetic resonance imaging (MRI) showed a mass lesion in the periventricular region, involving the splenium of the corpus callosum with restricted diffusion. The brain images were consistent with glioblastoma (GBM) or DLBCL (diffuse large B-cell lymphoma). The hypoperfusion of the lesion on MRI was of fundamental importance for the differential diagnosis, favouring the diagnosis of  DLBCL.