Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais brasileiros de dermatologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962018000500680 |
Resumo: | Abstract: Background: Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. TNMB system is the staging method used in MF, and it not only guides therapeutic management, but represents the main prognostic factor. In order to improve the prognostic evaluation, the Cutaneous Lymphoma International Prognostic Index (CLIPi) was proposed. Objective: To evaluate the performance of CLIPi score for prognostic analysis in patients with early stage MF. Methods: This is a retrospective cross-sectional observational study, with exploratory analysis. The outcome variables were disease progression and related death. Results: One hundred and two patients were stratified according to CLIPi score, being the majority classified as low risk. Patients with intermediate or high risk presented disease progression more frequently than those with low risk (PR: 1.2 / p = 0.004 / 95%CI: 1.0 - 1.6). The same did not occur with the variable related death. In addition, survival rates were not consistent with risk stratification. Study Limitations: Small sample and its retrospective analysis. Conclusions: Since CLIPi score was proposed, four other studies that we could consult showed conflicting results, similar to the present study. Further studies are necessary for a recommendation of its use. |
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Anais brasileiros de dermatologia (Online) |
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Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoidesLymphomaLymphoma, T-cell, cutaneousMycosis fungoidesAbstract: Background: Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. TNMB system is the staging method used in MF, and it not only guides therapeutic management, but represents the main prognostic factor. In order to improve the prognostic evaluation, the Cutaneous Lymphoma International Prognostic Index (CLIPi) was proposed. Objective: To evaluate the performance of CLIPi score for prognostic analysis in patients with early stage MF. Methods: This is a retrospective cross-sectional observational study, with exploratory analysis. The outcome variables were disease progression and related death. Results: One hundred and two patients were stratified according to CLIPi score, being the majority classified as low risk. Patients with intermediate or high risk presented disease progression more frequently than those with low risk (PR: 1.2 / p = 0.004 / 95%CI: 1.0 - 1.6). The same did not occur with the variable related death. In addition, survival rates were not consistent with risk stratification. Study Limitations: Small sample and its retrospective analysis. Conclusions: Since CLIPi score was proposed, four other studies that we could consult showed conflicting results, similar to the present study. Further studies are necessary for a recommendation of its use.Sociedade Brasileira de Dermatologia2018-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962018000500680Anais Brasileiros de Dermatologia v.93 n.5 2018reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20187134info:eu-repo/semantics/openAccessAmorim,Gustavo MoreiraCorbellini,João Paulo NiemeyerQuintella,Danielle CarvalhoCuzzi,TulliaRamos-e-Silva,Márciaeng2018-08-22T00:00:00Zoai:scielo:S0365-05962018000500680Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2018-08-22T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false |
dc.title.none.fl_str_mv |
Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides |
title |
Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides |
spellingShingle |
Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides Amorim,Gustavo Moreira Lymphoma Lymphoma, T-cell, cutaneous Mycosis fungoides |
title_short |
Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides |
title_full |
Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides |
title_fullStr |
Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides |
title_full_unstemmed |
Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides |
title_sort |
Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides |
author |
Amorim,Gustavo Moreira |
author_facet |
Amorim,Gustavo Moreira Corbellini,João Paulo Niemeyer Quintella,Danielle Carvalho Cuzzi,Tullia Ramos-e-Silva,Márcia |
author_role |
author |
author2 |
Corbellini,João Paulo Niemeyer Quintella,Danielle Carvalho Cuzzi,Tullia Ramos-e-Silva,Márcia |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Amorim,Gustavo Moreira Corbellini,João Paulo Niemeyer Quintella,Danielle Carvalho Cuzzi,Tullia Ramos-e-Silva,Márcia |
dc.subject.por.fl_str_mv |
Lymphoma Lymphoma, T-cell, cutaneous Mycosis fungoides |
topic |
Lymphoma Lymphoma, T-cell, cutaneous Mycosis fungoides |
description |
Abstract: Background: Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. TNMB system is the staging method used in MF, and it not only guides therapeutic management, but represents the main prognostic factor. In order to improve the prognostic evaluation, the Cutaneous Lymphoma International Prognostic Index (CLIPi) was proposed. Objective: To evaluate the performance of CLIPi score for prognostic analysis in patients with early stage MF. Methods: This is a retrospective cross-sectional observational study, with exploratory analysis. The outcome variables were disease progression and related death. Results: One hundred and two patients were stratified according to CLIPi score, being the majority classified as low risk. Patients with intermediate or high risk presented disease progression more frequently than those with low risk (PR: 1.2 / p = 0.004 / 95%CI: 1.0 - 1.6). The same did not occur with the variable related death. In addition, survival rates were not consistent with risk stratification. Study Limitations: Small sample and its retrospective analysis. Conclusions: Since CLIPi score was proposed, four other studies that we could consult showed conflicting results, similar to the present study. Further studies are necessary for a recommendation of its use. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962018000500680 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962018000500680 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/abd1806-4841.20187134 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
publisher.none.fl_str_mv |
Sociedade Brasileira de Dermatologia |
dc.source.none.fl_str_mv |
Anais Brasileiros de Dermatologia v.93 n.5 2018 reponame:Anais brasileiros de dermatologia (Online) instname:Sociedade Brasileira de Dermatologia (SBD) instacron:SBD |
instname_str |
Sociedade Brasileira de Dermatologia (SBD) |
instacron_str |
SBD |
institution |
SBD |
reponame_str |
Anais brasileiros de dermatologia (Online) |
collection |
Anais brasileiros de dermatologia (Online) |
repository.name.fl_str_mv |
Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD) |
repository.mail.fl_str_mv |
abd@sbd.org.br||revista@sbd.org.br |
_version_ |
1752126422992814080 |