Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides

Detalhes bibliográficos
Autor(a) principal: Amorim,Gustavo Moreira
Data de Publicação: 2018
Outros Autores: Corbellini,João Paulo Niemeyer, Quintella,Danielle Carvalho, Cuzzi,Tullia, Ramos-e-Silva,Márcia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962018000500680
Resumo: Abstract: Background: Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. TNMB system is the staging method used in MF, and it not only guides therapeutic management, but represents the main prognostic factor. In order to improve the prognostic evaluation, the Cutaneous Lymphoma International Prognostic Index (CLIPi) was proposed. Objective: To evaluate the performance of CLIPi score for prognostic analysis in patients with early stage MF. Methods: This is a retrospective cross-sectional observational study, with exploratory analysis. The outcome variables were disease progression and related death. Results: One hundred and two patients were stratified according to CLIPi score, being the majority classified as low risk. Patients with intermediate or high risk presented disease progression more frequently than those with low risk (PR: 1.2 / p = 0.004 / 95%CI: 1.0 - 1.6). The same did not occur with the variable related death. In addition, survival rates were not consistent with risk stratification. Study Limitations: Small sample and its retrospective analysis. Conclusions: Since CLIPi score was proposed, four other studies that we could consult showed conflicting results, similar to the present study. Further studies are necessary for a recommendation of its use.
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spelling Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoidesLymphomaLymphoma, T-cell, cutaneousMycosis fungoidesAbstract: Background: Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. TNMB system is the staging method used in MF, and it not only guides therapeutic management, but represents the main prognostic factor. In order to improve the prognostic evaluation, the Cutaneous Lymphoma International Prognostic Index (CLIPi) was proposed. Objective: To evaluate the performance of CLIPi score for prognostic analysis in patients with early stage MF. Methods: This is a retrospective cross-sectional observational study, with exploratory analysis. The outcome variables were disease progression and related death. Results: One hundred and two patients were stratified according to CLIPi score, being the majority classified as low risk. Patients with intermediate or high risk presented disease progression more frequently than those with low risk (PR: 1.2 / p = 0.004 / 95%CI: 1.0 - 1.6). The same did not occur with the variable related death. In addition, survival rates were not consistent with risk stratification. Study Limitations: Small sample and its retrospective analysis. Conclusions: Since CLIPi score was proposed, four other studies that we could consult showed conflicting results, similar to the present study. Further studies are necessary for a recommendation of its use.Sociedade Brasileira de Dermatologia2018-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962018000500680Anais Brasileiros de Dermatologia v.93 n.5 2018reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20187134info:eu-repo/semantics/openAccessAmorim,Gustavo MoreiraCorbellini,João Paulo NiemeyerQuintella,Danielle CarvalhoCuzzi,TulliaRamos-e-Silva,Márciaeng2018-08-22T00:00:00Zoai:scielo:S0365-05962018000500680Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2018-08-22T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides
title Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides
spellingShingle Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides
Amorim,Gustavo Moreira
Lymphoma
Lymphoma, T-cell, cutaneous
Mycosis fungoides
title_short Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides
title_full Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides
title_fullStr Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides
title_full_unstemmed Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides
title_sort Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides
author Amorim,Gustavo Moreira
author_facet Amorim,Gustavo Moreira
Corbellini,João Paulo Niemeyer
Quintella,Danielle Carvalho
Cuzzi,Tullia
Ramos-e-Silva,Márcia
author_role author
author2 Corbellini,João Paulo Niemeyer
Quintella,Danielle Carvalho
Cuzzi,Tullia
Ramos-e-Silva,Márcia
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Amorim,Gustavo Moreira
Corbellini,João Paulo Niemeyer
Quintella,Danielle Carvalho
Cuzzi,Tullia
Ramos-e-Silva,Márcia
dc.subject.por.fl_str_mv Lymphoma
Lymphoma, T-cell, cutaneous
Mycosis fungoides
topic Lymphoma
Lymphoma, T-cell, cutaneous
Mycosis fungoides
description Abstract: Background: Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. TNMB system is the staging method used in MF, and it not only guides therapeutic management, but represents the main prognostic factor. In order to improve the prognostic evaluation, the Cutaneous Lymphoma International Prognostic Index (CLIPi) was proposed. Objective: To evaluate the performance of CLIPi score for prognostic analysis in patients with early stage MF. Methods: This is a retrospective cross-sectional observational study, with exploratory analysis. The outcome variables were disease progression and related death. Results: One hundred and two patients were stratified according to CLIPi score, being the majority classified as low risk. Patients with intermediate or high risk presented disease progression more frequently than those with low risk (PR: 1.2 / p = 0.004 / 95%CI: 1.0 - 1.6). The same did not occur with the variable related death. In addition, survival rates were not consistent with risk stratification. Study Limitations: Small sample and its retrospective analysis. Conclusions: Since CLIPi score was proposed, four other studies that we could consult showed conflicting results, similar to the present study. Further studies are necessary for a recommendation of its use.
publishDate 2018
dc.date.none.fl_str_mv 2018-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962018000500680
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962018000500680
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/abd1806-4841.20187134
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.93 n.5 2018
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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