Oral squamous cell carcinoma in young people with human papilomavirus / Carcinoma de Células Escamosas oral em pessoas jovens com papilomavírus humano
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Health Review |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/48581 |
Resumo: | Introduction: The growth of oral squamous cell carcinoma (SCC) in positive human papillomavirus (HPV) patients is observed. The epidemiological profile is: young men, non-smokers and non-alcoholics. This is attributed to changes in promiscuous sexual practice. Objective: To understand HPV carcinogenesis, epidemiological and preventive implications. Methods: An integrative review of the literature was carried out in March 2018 in the PubMed and Science Direct databases. The descriptors used were: SCC, Young, HPV and Staging, combined by the AND modulator. Inclusion criteria were articles published in the last 10 years, related to the thematic and in the English, Portuguese and Spanish languages. In the PubMed were found 75 articles, after the application of the inclusion criteria were selected 64 articles for study. In the Science Direct were found 8 articles, after applying the selection criteria was selected 1 article for analysis. Results: HPV subtypes 16 and 18 are the most virulent. HPV is carcinogenic through the E6 and E7 genes. E6 inactivates the tumor suppressor gene p53. E7 inactivates the tumor suppressor gene pRb, resulting in overexpression of the p16 tumor suppressor protein that is associated with a better prognosis. The impact of TNM staging changed over time, the effect of N staging on mortality reduced, while the impact of T staging increased. Conclusion: Protected sexual practice and vaccination are efficient measures for the control of SCC, HPV positive. Therefore, the campaigns should be extended to the male audience. In addition, the staging of the disease should be updated for a better prognosis. |
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Brazilian Journal of Health Review |
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Oral squamous cell carcinoma in young people with human papilomavirus / Carcinoma de Células Escamosas oral em pessoas jovens com papilomavírus humanosquamous cell carcinomayounghuman papillomavirus and staging.Introduction: The growth of oral squamous cell carcinoma (SCC) in positive human papillomavirus (HPV) patients is observed. The epidemiological profile is: young men, non-smokers and non-alcoholics. This is attributed to changes in promiscuous sexual practice. Objective: To understand HPV carcinogenesis, epidemiological and preventive implications. Methods: An integrative review of the literature was carried out in March 2018 in the PubMed and Science Direct databases. The descriptors used were: SCC, Young, HPV and Staging, combined by the AND modulator. Inclusion criteria were articles published in the last 10 years, related to the thematic and in the English, Portuguese and Spanish languages. In the PubMed were found 75 articles, after the application of the inclusion criteria were selected 64 articles for study. In the Science Direct were found 8 articles, after applying the selection criteria was selected 1 article for analysis. Results: HPV subtypes 16 and 18 are the most virulent. HPV is carcinogenic through the E6 and E7 genes. E6 inactivates the tumor suppressor gene p53. E7 inactivates the tumor suppressor gene pRb, resulting in overexpression of the p16 tumor suppressor protein that is associated with a better prognosis. The impact of TNM staging changed over time, the effect of N staging on mortality reduced, while the impact of T staging increased. Conclusion: Protected sexual practice and vaccination are efficient measures for the control of SCC, HPV positive. Therefore, the campaigns should be extended to the male audience. In addition, the staging of the disease should be updated for a better prognosis.Brazilian Journals Publicações de Periódicos e Editora Ltda.2022-05-26info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/4858110.34119/bjhrv5n3-189Brazilian Journal of Health Review; Vol. 5 No. 3 (2022); 10247-10251Brazilian Journal of Health Review; v. 5 n. 3 (2022); 10247-102512595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/48581/pdfCopyright (c) 2022 Brazilian Journal of Health Reviewinfo:eu-repo/semantics/openAccessVieira, Carolina MedeirosMota, Emanuelly Botelho Rochados Santos, Luís Antônio Nogueirae Silva, Michele Versiani2022-06-30T18:51:12Zoai:ojs2.ojs.brazilianjournals.com.br:article/48581Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2022-06-30T18:51:12Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false |
dc.title.none.fl_str_mv |
Oral squamous cell carcinoma in young people with human papilomavirus / Carcinoma de Células Escamosas oral em pessoas jovens com papilomavírus humano |
title |
Oral squamous cell carcinoma in young people with human papilomavirus / Carcinoma de Células Escamosas oral em pessoas jovens com papilomavírus humano |
spellingShingle |
Oral squamous cell carcinoma in young people with human papilomavirus / Carcinoma de Células Escamosas oral em pessoas jovens com papilomavírus humano Vieira, Carolina Medeiros squamous cell carcinoma young human papillomavirus and staging. |
title_short |
Oral squamous cell carcinoma in young people with human papilomavirus / Carcinoma de Células Escamosas oral em pessoas jovens com papilomavírus humano |
title_full |
Oral squamous cell carcinoma in young people with human papilomavirus / Carcinoma de Células Escamosas oral em pessoas jovens com papilomavírus humano |
title_fullStr |
Oral squamous cell carcinoma in young people with human papilomavirus / Carcinoma de Células Escamosas oral em pessoas jovens com papilomavírus humano |
title_full_unstemmed |
Oral squamous cell carcinoma in young people with human papilomavirus / Carcinoma de Células Escamosas oral em pessoas jovens com papilomavírus humano |
title_sort |
Oral squamous cell carcinoma in young people with human papilomavirus / Carcinoma de Células Escamosas oral em pessoas jovens com papilomavírus humano |
author |
Vieira, Carolina Medeiros |
author_facet |
Vieira, Carolina Medeiros Mota, Emanuelly Botelho Rocha dos Santos, Luís Antônio Nogueira e Silva, Michele Versiani |
author_role |
author |
author2 |
Mota, Emanuelly Botelho Rocha dos Santos, Luís Antônio Nogueira e Silva, Michele Versiani |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Vieira, Carolina Medeiros Mota, Emanuelly Botelho Rocha dos Santos, Luís Antônio Nogueira e Silva, Michele Versiani |
dc.subject.por.fl_str_mv |
squamous cell carcinoma young human papillomavirus and staging. |
topic |
squamous cell carcinoma young human papillomavirus and staging. |
description |
Introduction: The growth of oral squamous cell carcinoma (SCC) in positive human papillomavirus (HPV) patients is observed. The epidemiological profile is: young men, non-smokers and non-alcoholics. This is attributed to changes in promiscuous sexual practice. Objective: To understand HPV carcinogenesis, epidemiological and preventive implications. Methods: An integrative review of the literature was carried out in March 2018 in the PubMed and Science Direct databases. The descriptors used were: SCC, Young, HPV and Staging, combined by the AND modulator. Inclusion criteria were articles published in the last 10 years, related to the thematic and in the English, Portuguese and Spanish languages. In the PubMed were found 75 articles, after the application of the inclusion criteria were selected 64 articles for study. In the Science Direct were found 8 articles, after applying the selection criteria was selected 1 article for analysis. Results: HPV subtypes 16 and 18 are the most virulent. HPV is carcinogenic through the E6 and E7 genes. E6 inactivates the tumor suppressor gene p53. E7 inactivates the tumor suppressor gene pRb, resulting in overexpression of the p16 tumor suppressor protein that is associated with a better prognosis. The impact of TNM staging changed over time, the effect of N staging on mortality reduced, while the impact of T staging increased. Conclusion: Protected sexual practice and vaccination are efficient measures for the control of SCC, HPV positive. Therefore, the campaigns should be extended to the male audience. In addition, the staging of the disease should be updated for a better prognosis. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-26 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/48581 10.34119/bjhrv5n3-189 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/48581 |
identifier_str_mv |
10.34119/bjhrv5n3-189 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/48581/pdf |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Brazilian Journal of Health Review info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Brazilian Journal of Health Review |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Health Review; Vol. 5 No. 3 (2022); 10247-10251 Brazilian Journal of Health Review; v. 5 n. 3 (2022); 10247-10251 2595-6825 reponame:Brazilian Journal of Health Review instname:Federação das Indústrias do Estado do Paraná (FIEP) instacron:BJRH |
instname_str |
Federação das Indústrias do Estado do Paraná (FIEP) |
instacron_str |
BJRH |
institution |
BJRH |
reponame_str |
Brazilian Journal of Health Review |
collection |
Brazilian Journal of Health Review |
repository.name.fl_str_mv |
Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP) |
repository.mail.fl_str_mv |
|| brazilianjhr@gmail.com |
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1797240075531059200 |