Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil

• Main Author: Beirão,Elisa Maria
• Publication Date: 2011
• Other Authors: Furtado,Juvencio Jose Duailibe, Girardello,Raquel, Ferreira Filho,Heli, Gales,Ana Cristina
• Format: Article
• Language: eng
• Source: Brazilian Journal of Infectious Diseases
• Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100013
• topic: Klebsiella pneumonia; KPC; hospital infection; carbapenemase

In 2008 isolates of KPC-producing Klebsiella pneumoniae (KPC-KPN) were detected for the first time at Hospital Heliópolis, São Paulo, Brazil. The aim of this study was to characterize the clinical and microbiological outcomes of infections caused by KPC-KPN. A historical cohort of patients from whom KPC-KPN strains were isolated was performed. Isolates were identified as resistant to ertapenem by automated broth microdilution system and screened as carbapenemase producers by the modified Hodge test. The beta-lactamase resistance gene blaKPC was detected by PCR. The genetic relatedness of isolates was determined by PFGE. The study provides early clinical experience in treating KPC-KPN infections in a Brazilian tertiary center.