Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil

• Autor(a) principal: Beirão, Elisa Maria
• Data de Publicação: 2011
• Outros Autores: Furtado, Juvencio Jose Duailibe, Girardello, Raquel [UNIFESP], Ferreira Filho, Heli, Gales, Ana Cristina [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://repositorio.unifesp.br/handle/11600/6270; http://dx.doi.org/10.1590/S1413-86702011000100013
• topic: Klebsiella pneumonia; KPC; hospital infection; carbapenemase

In 2008 isolates of KPC-producing Klebsiella pneumoniae (KPC-KPN) were detected for the first time at Hospital Heliópolis, São Paulo, Brazil. The aim of this study was to characterize the clinical and microbiological outcomes of infections caused by KPC-KPN. A historical cohort of patients from whom KPC-KPN strains were isolated was performed. Isolates were identified as resistant to ertapenem by automated broth microdilution system and screened as carbapenemase producers by the modified Hodge test. The beta-lactamase resistance gene blaKPC was detected by PCR. The genetic relatedness of isolates was determined by PFGE. The study provides early clinical experience in treating KPC-KPN infections in a Brazilian tertiary center.