Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review

Detalhes bibliográficos
Autor(a) principal: Longhi,Renata Maronna Praça
Data de Publicação: 2013
Outros Autores: Zembrzuski,Verônica Marques, Basta,Paulo Cesar, Croda,Julio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Infectious Diseases
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300009
Resumo: We systematically reviewed studies of the immune response to tuberculosis and the genetic polymorphisms associated with Th1-or Th2-mediated cytokine expression in indigenous populations. A bibliographic search was performed on the Medline and ISI databases and included studies published between January 1980 and October 2011. The search terms were tuberculosis, American Indians, Amerindian, indigenous, Indians, native people, aboriginal, immun*, host immune, immune response, cytokine*, polymorphism*, and gene. Regardless of their design, studies that evaluated immunoglobulin, cytokine levels and genetic polymorphisms that altered cytokine expression were included. Thirteen studies met the inclusion criteria. The majority of studies were performed in Latin America, and five investigated the Warao ethnic group of Venezuela. Most of the investigations indirectly evaluated the immune response. Higher anergy to the tuberculin skin test, higher IgG4 and IgM levels, higher IL-5 production and lower TNF-a, IL-12p40 and IFN-I production were found in the indigenous populations. The studies also reported a predominantly Th2-type response in these populations and a possibly higher susceptibility to tuberculosis. A better understanding of the relevant genetic polymorphisms and their role in immune regulation would help to clarify the immunogenetic mechanisms of TB infection in these populations. This information would be useful for identifying new treatments and preventing infection and progression to active disease.
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spelling Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief reviewTuberculosisImmune responseIndigenous populationsPolymorphismWe systematically reviewed studies of the immune response to tuberculosis and the genetic polymorphisms associated with Th1-or Th2-mediated cytokine expression in indigenous populations. A bibliographic search was performed on the Medline and ISI databases and included studies published between January 1980 and October 2011. The search terms were tuberculosis, American Indians, Amerindian, indigenous, Indians, native people, aboriginal, immun*, host immune, immune response, cytokine*, polymorphism*, and gene. Regardless of their design, studies that evaluated immunoglobulin, cytokine levels and genetic polymorphisms that altered cytokine expression were included. Thirteen studies met the inclusion criteria. The majority of studies were performed in Latin America, and five investigated the Warao ethnic group of Venezuela. Most of the investigations indirectly evaluated the immune response. Higher anergy to the tuberculin skin test, higher IgG4 and IgM levels, higher IL-5 production and lower TNF-a, IL-12p40 and IFN-I production were found in the indigenous populations. The studies also reported a predominantly Th2-type response in these populations and a possibly higher susceptibility to tuberculosis. A better understanding of the relevant genetic polymorphisms and their role in immune regulation would help to clarify the immunogenetic mechanisms of TB infection in these populations. This information would be useful for identifying new treatments and preventing infection and progression to active disease.Brazilian Society of Infectious Diseases2013-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300009Brazilian Journal of Infectious Diseases v.17 n.3 2013reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1016/j.bjid.2012.11.001info:eu-repo/semantics/openAccessLonghi,Renata Maronna PraçaZembrzuski,Verônica MarquesBasta,Paulo CesarCroda,Julioeng2013-06-13T00:00:00Zoai:scielo:S1413-86702013000300009Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2013-06-13T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false
dc.title.none.fl_str_mv Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review
title Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review
spellingShingle Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review
Longhi,Renata Maronna Praça
Tuberculosis
Immune response
Indigenous populations
Polymorphism
title_short Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review
title_full Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review
title_fullStr Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review
title_full_unstemmed Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review
title_sort Genetic polymorphism and immune response to tuberculosis in indigenous populations: a brief review
author Longhi,Renata Maronna Praça
author_facet Longhi,Renata Maronna Praça
Zembrzuski,Verônica Marques
Basta,Paulo Cesar
Croda,Julio
author_role author
author2 Zembrzuski,Verônica Marques
Basta,Paulo Cesar
Croda,Julio
author2_role author
author
author
dc.contributor.author.fl_str_mv Longhi,Renata Maronna Praça
Zembrzuski,Verônica Marques
Basta,Paulo Cesar
Croda,Julio
dc.subject.por.fl_str_mv Tuberculosis
Immune response
Indigenous populations
Polymorphism
topic Tuberculosis
Immune response
Indigenous populations
Polymorphism
description We systematically reviewed studies of the immune response to tuberculosis and the genetic polymorphisms associated with Th1-or Th2-mediated cytokine expression in indigenous populations. A bibliographic search was performed on the Medline and ISI databases and included studies published between January 1980 and October 2011. The search terms were tuberculosis, American Indians, Amerindian, indigenous, Indians, native people, aboriginal, immun*, host immune, immune response, cytokine*, polymorphism*, and gene. Regardless of their design, studies that evaluated immunoglobulin, cytokine levels and genetic polymorphisms that altered cytokine expression were included. Thirteen studies met the inclusion criteria. The majority of studies were performed in Latin America, and five investigated the Warao ethnic group of Venezuela. Most of the investigations indirectly evaluated the immune response. Higher anergy to the tuberculin skin test, higher IgG4 and IgM levels, higher IL-5 production and lower TNF-a, IL-12p40 and IFN-I production were found in the indigenous populations. The studies also reported a predominantly Th2-type response in these populations and a possibly higher susceptibility to tuberculosis. A better understanding of the relevant genetic polymorphisms and their role in immune regulation would help to clarify the immunogenetic mechanisms of TB infection in these populations. This information would be useful for identifying new treatments and preventing infection and progression to active disease.
publishDate 2013
dc.date.none.fl_str_mv 2013-06-01
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300009
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjid.2012.11.001
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dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv Brazilian Journal of Infectious Diseases v.17 n.3 2013
reponame:Brazilian Journal of Infectious Diseases
instname:Brazilian Society of Infectious Diseases (BSID)
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instname_str Brazilian Society of Infectious Diseases (BSID)
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repository.name.fl_str_mv Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)
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