Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic

Detalhes bibliográficos
Autor(a) principal: Bandeira,Antonio Carlos
Data de Publicação: 2020
Outros Autores: Gois,Luana Leandro, Campos,Gubio Soares, Sardi,Silvia, Yssel,Hans, Vieillard,Vincent, Autran,Brigitte, Grassi,Maria Fernanda Rios
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Infectious Diseases
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000500405
Resumo: Abstract Several major epidemics of Zika fever, caused by the ZIKA virus (ZIKV), have emerged in Brazil since early 2015, eventually spreading to other countries on the South American continent. The present study describes the clinical manifestations and laboratory findings of patients with confirmed acute ZIKV infection during the first epidemic that occurred in Salvador, Brazil. All included patients were seen at the emergency room of a private tertiary hospital located in Salvador, Brazil from 2015 through 2017. Patients were considered eligible if signs of systemic viral febrile disease were present. All individuals were tested for ZIKV and Chikungunya infection using PCR, while rapid test was used to detect Dengue virus antibodies or, alternatively, the NS1 antigen. A diagnosis of acute ZIKV infection was confirmed in 78/434 (18%) individuals with systemic viral febrile illness. Positivity was mainly observed in blood, followed by saliva and urine. Coinfection with Chikungunya and/or Dengue virus was detected in 5% of the ZIKV-infected patients. The most frequent clinical findings were myalgia, arthralgia and low-grade fever. Laboratory analysis demonstrated normal levels of hematocrit, platelets and liver enzymes. In summary, in acute settings where molecular testing remains unavailable, clinicians face difficulties to confirm the diagnosis of ZIKV infection, as they rely only on clinical examinations and conventional laboratory tests.
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spelling Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemicZika virusClinical presentationPolymerase chain reactionBahiaAbstract Several major epidemics of Zika fever, caused by the ZIKA virus (ZIKV), have emerged in Brazil since early 2015, eventually spreading to other countries on the South American continent. The present study describes the clinical manifestations and laboratory findings of patients with confirmed acute ZIKV infection during the first epidemic that occurred in Salvador, Brazil. All included patients were seen at the emergency room of a private tertiary hospital located in Salvador, Brazil from 2015 through 2017. Patients were considered eligible if signs of systemic viral febrile disease were present. All individuals were tested for ZIKV and Chikungunya infection using PCR, while rapid test was used to detect Dengue virus antibodies or, alternatively, the NS1 antigen. A diagnosis of acute ZIKV infection was confirmed in 78/434 (18%) individuals with systemic viral febrile illness. Positivity was mainly observed in blood, followed by saliva and urine. Coinfection with Chikungunya and/or Dengue virus was detected in 5% of the ZIKV-infected patients. The most frequent clinical findings were myalgia, arthralgia and low-grade fever. Laboratory analysis demonstrated normal levels of hematocrit, platelets and liver enzymes. In summary, in acute settings where molecular testing remains unavailable, clinicians face difficulties to confirm the diagnosis of ZIKV infection, as they rely only on clinical examinations and conventional laboratory tests.Brazilian Society of Infectious Diseases2020-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000500405Brazilian Journal of Infectious Diseases v.24 n.5 2020reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1016/j.bjid.2020.08.005info:eu-repo/semantics/openAccessBandeira,Antonio CarlosGois,Luana LeandroCampos,Gubio SoaresSardi,SilviaYssel,HansVieillard,VincentAutran,BrigitteGrassi,Maria Fernanda Rioseng2020-11-26T00:00:00Zoai:scielo:S1413-86702020000500405Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2020-11-26T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false
dc.title.none.fl_str_mv Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic
title Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic
spellingShingle Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic
Bandeira,Antonio Carlos
Zika virus
Clinical presentation
Polymerase chain reaction
Bahia
title_short Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic
title_full Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic
title_fullStr Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic
title_full_unstemmed Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic
title_sort Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic
author Bandeira,Antonio Carlos
author_facet Bandeira,Antonio Carlos
Gois,Luana Leandro
Campos,Gubio Soares
Sardi,Silvia
Yssel,Hans
Vieillard,Vincent
Autran,Brigitte
Grassi,Maria Fernanda Rios
author_role author
author2 Gois,Luana Leandro
Campos,Gubio Soares
Sardi,Silvia
Yssel,Hans
Vieillard,Vincent
Autran,Brigitte
Grassi,Maria Fernanda Rios
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bandeira,Antonio Carlos
Gois,Luana Leandro
Campos,Gubio Soares
Sardi,Silvia
Yssel,Hans
Vieillard,Vincent
Autran,Brigitte
Grassi,Maria Fernanda Rios
dc.subject.por.fl_str_mv Zika virus
Clinical presentation
Polymerase chain reaction
Bahia
topic Zika virus
Clinical presentation
Polymerase chain reaction
Bahia
description Abstract Several major epidemics of Zika fever, caused by the ZIKA virus (ZIKV), have emerged in Brazil since early 2015, eventually spreading to other countries on the South American continent. The present study describes the clinical manifestations and laboratory findings of patients with confirmed acute ZIKV infection during the first epidemic that occurred in Salvador, Brazil. All included patients were seen at the emergency room of a private tertiary hospital located in Salvador, Brazil from 2015 through 2017. Patients were considered eligible if signs of systemic viral febrile disease were present. All individuals were tested for ZIKV and Chikungunya infection using PCR, while rapid test was used to detect Dengue virus antibodies or, alternatively, the NS1 antigen. A diagnosis of acute ZIKV infection was confirmed in 78/434 (18%) individuals with systemic viral febrile illness. Positivity was mainly observed in blood, followed by saliva and urine. Coinfection with Chikungunya and/or Dengue virus was detected in 5% of the ZIKV-infected patients. The most frequent clinical findings were myalgia, arthralgia and low-grade fever. Laboratory analysis demonstrated normal levels of hematocrit, platelets and liver enzymes. In summary, in acute settings where molecular testing remains unavailable, clinicians face difficulties to confirm the diagnosis of ZIKV infection, as they rely only on clinical examinations and conventional laboratory tests.
publishDate 2020
dc.date.none.fl_str_mv 2020-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000500405
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000500405
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjid.2020.08.005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv Brazilian Journal of Infectious Diseases v.24 n.5 2020
reponame:Brazilian Journal of Infectious Diseases
instname:Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
instname_str Brazilian Society of Infectious Diseases (BSID)
instacron_str BSID
institution BSID
reponame_str Brazilian Journal of Infectious Diseases
collection Brazilian Journal of Infectious Diseases
repository.name.fl_str_mv Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)
repository.mail.fl_str_mv bjid@bjid.org.br||lgoldani@ufrgs.br
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