Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000500405 |
Resumo: | Abstract Several major epidemics of Zika fever, caused by the ZIKA virus (ZIKV), have emerged in Brazil since early 2015, eventually spreading to other countries on the South American continent. The present study describes the clinical manifestations and laboratory findings of patients with confirmed acute ZIKV infection during the first epidemic that occurred in Salvador, Brazil. All included patients were seen at the emergency room of a private tertiary hospital located in Salvador, Brazil from 2015 through 2017. Patients were considered eligible if signs of systemic viral febrile disease were present. All individuals were tested for ZIKV and Chikungunya infection using PCR, while rapid test was used to detect Dengue virus antibodies or, alternatively, the NS1 antigen. A diagnosis of acute ZIKV infection was confirmed in 78/434 (18%) individuals with systemic viral febrile illness. Positivity was mainly observed in blood, followed by saliva and urine. Coinfection with Chikungunya and/or Dengue virus was detected in 5% of the ZIKV-infected patients. The most frequent clinical findings were myalgia, arthralgia and low-grade fever. Laboratory analysis demonstrated normal levels of hematocrit, platelets and liver enzymes. In summary, in acute settings where molecular testing remains unavailable, clinicians face difficulties to confirm the diagnosis of ZIKV infection, as they rely only on clinical examinations and conventional laboratory tests. |
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Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemicZika virusClinical presentationPolymerase chain reactionBahiaAbstract Several major epidemics of Zika fever, caused by the ZIKA virus (ZIKV), have emerged in Brazil since early 2015, eventually spreading to other countries on the South American continent. The present study describes the clinical manifestations and laboratory findings of patients with confirmed acute ZIKV infection during the first epidemic that occurred in Salvador, Brazil. All included patients were seen at the emergency room of a private tertiary hospital located in Salvador, Brazil from 2015 through 2017. Patients were considered eligible if signs of systemic viral febrile disease were present. All individuals were tested for ZIKV and Chikungunya infection using PCR, while rapid test was used to detect Dengue virus antibodies or, alternatively, the NS1 antigen. A diagnosis of acute ZIKV infection was confirmed in 78/434 (18%) individuals with systemic viral febrile illness. Positivity was mainly observed in blood, followed by saliva and urine. Coinfection with Chikungunya and/or Dengue virus was detected in 5% of the ZIKV-infected patients. The most frequent clinical findings were myalgia, arthralgia and low-grade fever. Laboratory analysis demonstrated normal levels of hematocrit, platelets and liver enzymes. In summary, in acute settings where molecular testing remains unavailable, clinicians face difficulties to confirm the diagnosis of ZIKV infection, as they rely only on clinical examinations and conventional laboratory tests.Brazilian Society of Infectious Diseases2020-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000500405Brazilian Journal of Infectious Diseases v.24 n.5 2020reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1016/j.bjid.2020.08.005info:eu-repo/semantics/openAccessBandeira,Antonio CarlosGois,Luana LeandroCampos,Gubio SoaresSardi,SilviaYssel,HansVieillard,VincentAutran,BrigitteGrassi,Maria Fernanda Rioseng2020-11-26T00:00:00Zoai:scielo:S1413-86702020000500405Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2020-11-26T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic |
title |
Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic |
spellingShingle |
Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic Bandeira,Antonio Carlos Zika virus Clinical presentation Polymerase chain reaction Bahia |
title_short |
Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic |
title_full |
Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic |
title_fullStr |
Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic |
title_full_unstemmed |
Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic |
title_sort |
Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic |
author |
Bandeira,Antonio Carlos |
author_facet |
Bandeira,Antonio Carlos Gois,Luana Leandro Campos,Gubio Soares Sardi,Silvia Yssel,Hans Vieillard,Vincent Autran,Brigitte Grassi,Maria Fernanda Rios |
author_role |
author |
author2 |
Gois,Luana Leandro Campos,Gubio Soares Sardi,Silvia Yssel,Hans Vieillard,Vincent Autran,Brigitte Grassi,Maria Fernanda Rios |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Bandeira,Antonio Carlos Gois,Luana Leandro Campos,Gubio Soares Sardi,Silvia Yssel,Hans Vieillard,Vincent Autran,Brigitte Grassi,Maria Fernanda Rios |
dc.subject.por.fl_str_mv |
Zika virus Clinical presentation Polymerase chain reaction Bahia |
topic |
Zika virus Clinical presentation Polymerase chain reaction Bahia |
description |
Abstract Several major epidemics of Zika fever, caused by the ZIKA virus (ZIKV), have emerged in Brazil since early 2015, eventually spreading to other countries on the South American continent. The present study describes the clinical manifestations and laboratory findings of patients with confirmed acute ZIKV infection during the first epidemic that occurred in Salvador, Brazil. All included patients were seen at the emergency room of a private tertiary hospital located in Salvador, Brazil from 2015 through 2017. Patients were considered eligible if signs of systemic viral febrile disease were present. All individuals were tested for ZIKV and Chikungunya infection using PCR, while rapid test was used to detect Dengue virus antibodies or, alternatively, the NS1 antigen. A diagnosis of acute ZIKV infection was confirmed in 78/434 (18%) individuals with systemic viral febrile illness. Positivity was mainly observed in blood, followed by saliva and urine. Coinfection with Chikungunya and/or Dengue virus was detected in 5% of the ZIKV-infected patients. The most frequent clinical findings were myalgia, arthralgia and low-grade fever. Laboratory analysis demonstrated normal levels of hematocrit, platelets and liver enzymes. In summary, in acute settings where molecular testing remains unavailable, clinicians face difficulties to confirm the diagnosis of ZIKV infection, as they rely only on clinical examinations and conventional laboratory tests. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000500405 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000500405 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjid.2020.08.005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.24 n.5 2020 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
_version_ |
1754209245101817856 |