Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/44455 |
Resumo: | Con- selho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and Fundacao Nacional de Desenvolvimento do Ensino Superior Particular (FUNADESP). The authors are grateful to Andris K. Walter for English language revision and copyediting services. |
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Bandeira, Antonio CarlosGois, Luana LeandroCampos, Gubio SoaresSardi, SilviaYssel, HansVieillard, VincentAutran, BrigitteGrassi, Maria Fernanda Rios2020-11-17T11:56:40Z2020-11-17T11:56:40Z2020BANDEIRA, Antonio Carlos et al. Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic. The Brazilian Journal of Infectious Diseases, v. 24, n. 5, p. 405-411, 2020.1413-8670https://www.arca.fiocruz.br/handle/icict/4445510.1016/j.bjid.2020.08.005Con- selho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and Fundacao Nacional de Desenvolvimento do Ensino Superior Particular (FUNADESP). The authors are grateful to Andris K. Walter for English language revision and copyediting services.UniFTC. Faculdade de Medicina. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil.Universite Pierre Marie-Curie. Sorbonne Universite. Centre d'Immunologie et des Maladies Infectieuses. Paris, France.Universite Pierre Marie-Curie. Sorbonne Universite. Centre d'Immunologie et des Maladies Infectieuses. Paris, France.Universite Pierre Marie-Curie. Sorbonne Universite. Centre d'Immunologie et des Maladies Infectieuses. Paris, France.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Several major epidemics of Zika fever, caused by the ZIKA virus (ZIKV), have emerged in Brazil since early 2015, eventually spreading to other countries on the South American con- tinent. The present study describes the clinical manifestations and laboratory findings of patients with confirmed acute ZIKV infection during the first epidemic that occurred in Sal- vador, Brazil. All included patients were seen at the emergency room of a private tertiary hospital located in Salvador, Brazil from 2015 through 2017. Patients were considered eligible if signs of systemic viral febrile disease were present. All individuals were tested for ZIKV and Chikungunya infection using PCR, while rapid test was used to detect Dengue virus anti- bodies or, alternatively, the NS1 antigen. A diagnosis of acute ZIKV infection was confirmed in 78/434 (18%) individuals with systemic viral febrile illness. Positivity was mainly observed in blood, followed by saliva and urine. Coinfection with Chikungunya and/or Dengue virus was detected in 5% of the ZIKV-infected patients. The most frequent clinical findings were myalgia, arthralgia and low-grade fever. Laboratory analysis demonstrated normal levels of hematocrit, platelets and liver enzymes. In summary, in acute settings where molecu- lar testing remains unavailable, clinicians face difficulties to confirm the diagnosis of ZIKV infection, as they rely only on clinical examinations and conventional laboratory testsengSociedade Brasileira de InfectologiaVírus zikaEpidemiaReação em cadeia da polimeraseBrasilZika virusClinical presentationPolymerase chain reactionBahiaClinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemicinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/44455/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALBandeira, Antonio Carlos. 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| dc.title.pt_BR.fl_str_mv |
Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic |
| title |
Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic |
| spellingShingle |
Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic Bandeira, Antonio Carlos Vírus zika Epidemia Reação em cadeia da polimerase Brasil Zika virus Clinical presentation Polymerase chain reaction Bahia |
| title_short |
Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic |
| title_full |
Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic |
| title_fullStr |
Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic |
| title_full_unstemmed |
Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic |
| title_sort |
Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic |
| author |
Bandeira, Antonio Carlos |
| author_facet |
Bandeira, Antonio Carlos Gois, Luana Leandro Campos, Gubio Soares Sardi, Silvia Yssel, Hans Vieillard, Vincent Autran, Brigitte Grassi, Maria Fernanda Rios |
| author_role |
author |
| author2 |
Gois, Luana Leandro Campos, Gubio Soares Sardi, Silvia Yssel, Hans Vieillard, Vincent Autran, Brigitte Grassi, Maria Fernanda Rios |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bandeira, Antonio Carlos Gois, Luana Leandro Campos, Gubio Soares Sardi, Silvia Yssel, Hans Vieillard, Vincent Autran, Brigitte Grassi, Maria Fernanda Rios |
| dc.subject.other.pt_BR.fl_str_mv |
Vírus zika Epidemia Reação em cadeia da polimerase Brasil |
| topic |
Vírus zika Epidemia Reação em cadeia da polimerase Brasil Zika virus Clinical presentation Polymerase chain reaction Bahia |
| dc.subject.en.pt_BR.fl_str_mv |
Zika virus Clinical presentation Polymerase chain reaction Bahia |
| description |
Con- selho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and Fundacao Nacional de Desenvolvimento do Ensino Superior Particular (FUNADESP). The authors are grateful to Andris K. Walter for English language revision and copyediting services. |
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2020 |
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2020-11-17T11:56:40Z |
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2020-11-17T11:56:40Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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BANDEIRA, Antonio Carlos et al. Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic. The Brazilian Journal of Infectious Diseases, v. 24, n. 5, p. 405-411, 2020. |
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https://www.arca.fiocruz.br/handle/icict/44455 |
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1413-8670 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.bjid.2020.08.005 |
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BANDEIRA, Antonio Carlos et al. Clinical and laboratory findings of acute Zika virus infection in patients from Salvador during the first Brazilian epidemic. The Brazilian Journal of Infectious Diseases, v. 24, n. 5, p. 405-411, 2020. 1413-8670 10.1016/j.bjid.2020.08.005 |
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Sociedade Brasileira de Infectologia |
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Sociedade Brasileira de Infectologia |
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