Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis

Detalhes bibliográficos
Autor(a) principal: Fadlallah,Ali
Data de Publicação: 2012
Outros Autores: Rami,Hala El, Fahd,Daoud, Dunia,Ibrahim, Bejjani,Riad, Chlela,Elie, Waked,Naji, Jabbour,Elyse, Fahed,Sharbel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000300006
Resumo: PURPOSE: To assess the efficacy of topical 1.5% azithromycin in the treatment of moderate to severe chronic blepharitis and to compare the efficacy of two different treatment modalities. METHODS: A randomized clinical trial included 67 patients with chronic anterior and/or posterior blepharitis, followed-up for 3 months. Signs and symptoms were graded according to severity. Patients were randomized into two groups: 33 patients in group I and 34 patients in group II. Group I patients were treated with topical 1.5% azithromycin twice a day for three days, and Group II patients were treated with topical 1.5% azithromycin twice a day for three days then at bedtime for the rest of the month. All patients were instructed to apply warm compresses and an eye-friendly soap twice daily. RESULTS: Patients in both groups tolerated the treatment with minimal irritation. A significant improvement in signs and symptoms was noted at the one week follow-up visit. Group II showed a more pronounced and longer-lasting improvement that persisted after three months of follow-up. CONCLUSION: Topical 1.5% azithromycin ophthalmic solution is an effective treatment option for chronic blepharitis. In moderate to severe blepharitis, a one month treatment is safe and shows better improvement than the three-day protocol with no significant relapse until three months of follow-up.
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spelling Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitisAzithromycin/administration & dosageBlepharitis/drug therapyChronic diseaseOphthalmic solutionsMeibomian glandsPURPOSE: To assess the efficacy of topical 1.5% azithromycin in the treatment of moderate to severe chronic blepharitis and to compare the efficacy of two different treatment modalities. METHODS: A randomized clinical trial included 67 patients with chronic anterior and/or posterior blepharitis, followed-up for 3 months. Signs and symptoms were graded according to severity. Patients were randomized into two groups: 33 patients in group I and 34 patients in group II. Group I patients were treated with topical 1.5% azithromycin twice a day for three days, and Group II patients were treated with topical 1.5% azithromycin twice a day for three days then at bedtime for the rest of the month. All patients were instructed to apply warm compresses and an eye-friendly soap twice daily. RESULTS: Patients in both groups tolerated the treatment with minimal irritation. A significant improvement in signs and symptoms was noted at the one week follow-up visit. Group II showed a more pronounced and longer-lasting improvement that persisted after three months of follow-up. CONCLUSION: Topical 1.5% azithromycin ophthalmic solution is an effective treatment option for chronic blepharitis. In moderate to severe blepharitis, a one month treatment is safe and shows better improvement than the three-day protocol with no significant relapse until three months of follow-up.Conselho Brasileiro de Oftalmologia2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000300006Arquivos Brasileiros de Oftalmologia v.75 n.3 2012reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492012000300006info:eu-repo/semantics/openAccessFadlallah,AliRami,Hala ElFahd,DaoudDunia,IbrahimBejjani,RiadChlela,ElieWaked,NajiJabbour,ElyseFahed,Sharbeleng2012-08-02T00:00:00Zoai:scielo:S0004-27492012000300006Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2012-08-02T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis
title Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis
spellingShingle Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis
Fadlallah,Ali
Azithromycin/administration & dosage
Blepharitis/drug therapy
Chronic disease
Ophthalmic solutions
Meibomian glands
title_short Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis
title_full Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis
title_fullStr Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis
title_full_unstemmed Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis
title_sort Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis
author Fadlallah,Ali
author_facet Fadlallah,Ali
Rami,Hala El
Fahd,Daoud
Dunia,Ibrahim
Bejjani,Riad
Chlela,Elie
Waked,Naji
Jabbour,Elyse
Fahed,Sharbel
author_role author
author2 Rami,Hala El
Fahd,Daoud
Dunia,Ibrahim
Bejjani,Riad
Chlela,Elie
Waked,Naji
Jabbour,Elyse
Fahed,Sharbel
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fadlallah,Ali
Rami,Hala El
Fahd,Daoud
Dunia,Ibrahim
Bejjani,Riad
Chlela,Elie
Waked,Naji
Jabbour,Elyse
Fahed,Sharbel
dc.subject.por.fl_str_mv Azithromycin/administration & dosage
Blepharitis/drug therapy
Chronic disease
Ophthalmic solutions
Meibomian glands
topic Azithromycin/administration & dosage
Blepharitis/drug therapy
Chronic disease
Ophthalmic solutions
Meibomian glands
description PURPOSE: To assess the efficacy of topical 1.5% azithromycin in the treatment of moderate to severe chronic blepharitis and to compare the efficacy of two different treatment modalities. METHODS: A randomized clinical trial included 67 patients with chronic anterior and/or posterior blepharitis, followed-up for 3 months. Signs and symptoms were graded according to severity. Patients were randomized into two groups: 33 patients in group I and 34 patients in group II. Group I patients were treated with topical 1.5% azithromycin twice a day for three days, and Group II patients were treated with topical 1.5% azithromycin twice a day for three days then at bedtime for the rest of the month. All patients were instructed to apply warm compresses and an eye-friendly soap twice daily. RESULTS: Patients in both groups tolerated the treatment with minimal irritation. A significant improvement in signs and symptoms was noted at the one week follow-up visit. Group II showed a more pronounced and longer-lasting improvement that persisted after three months of follow-up. CONCLUSION: Topical 1.5% azithromycin ophthalmic solution is an effective treatment option for chronic blepharitis. In moderate to severe blepharitis, a one month treatment is safe and shows better improvement than the three-day protocol with no significant relapse until three months of follow-up.
publishDate 2012
dc.date.none.fl_str_mv 2012-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000300006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000300006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0004-27492012000300006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.75 n.3 2012
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
instname_str Conselho Brasileiro de Oftalmologia (CBO)
instacron_str CBO
institution CBO
reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
repository.mail.fl_str_mv aboonline@cbo.com.br||abo@cbo.com.br
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