Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Arquivos brasileiros de oftalmologia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000300006 |
Resumo: | PURPOSE: To assess the efficacy of topical 1.5% azithromycin in the treatment of moderate to severe chronic blepharitis and to compare the efficacy of two different treatment modalities. METHODS: A randomized clinical trial included 67 patients with chronic anterior and/or posterior blepharitis, followed-up for 3 months. Signs and symptoms were graded according to severity. Patients were randomized into two groups: 33 patients in group I and 34 patients in group II. Group I patients were treated with topical 1.5% azithromycin twice a day for three days, and Group II patients were treated with topical 1.5% azithromycin twice a day for three days then at bedtime for the rest of the month. All patients were instructed to apply warm compresses and an eye-friendly soap twice daily. RESULTS: Patients in both groups tolerated the treatment with minimal irritation. A significant improvement in signs and symptoms was noted at the one week follow-up visit. Group II showed a more pronounced and longer-lasting improvement that persisted after three months of follow-up. CONCLUSION: Topical 1.5% azithromycin ophthalmic solution is an effective treatment option for chronic blepharitis. In moderate to severe blepharitis, a one month treatment is safe and shows better improvement than the three-day protocol with no significant relapse until three months of follow-up. |
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Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitisAzithromycin/administration & dosageBlepharitis/drug therapyChronic diseaseOphthalmic solutionsMeibomian glandsPURPOSE: To assess the efficacy of topical 1.5% azithromycin in the treatment of moderate to severe chronic blepharitis and to compare the efficacy of two different treatment modalities. METHODS: A randomized clinical trial included 67 patients with chronic anterior and/or posterior blepharitis, followed-up for 3 months. Signs and symptoms were graded according to severity. Patients were randomized into two groups: 33 patients in group I and 34 patients in group II. Group I patients were treated with topical 1.5% azithromycin twice a day for three days, and Group II patients were treated with topical 1.5% azithromycin twice a day for three days then at bedtime for the rest of the month. All patients were instructed to apply warm compresses and an eye-friendly soap twice daily. RESULTS: Patients in both groups tolerated the treatment with minimal irritation. A significant improvement in signs and symptoms was noted at the one week follow-up visit. Group II showed a more pronounced and longer-lasting improvement that persisted after three months of follow-up. CONCLUSION: Topical 1.5% azithromycin ophthalmic solution is an effective treatment option for chronic blepharitis. In moderate to severe blepharitis, a one month treatment is safe and shows better improvement than the three-day protocol with no significant relapse until three months of follow-up.Conselho Brasileiro de Oftalmologia2012-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000300006Arquivos Brasileiros de Oftalmologia v.75 n.3 2012reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.1590/S0004-27492012000300006info:eu-repo/semantics/openAccessFadlallah,AliRami,Hala ElFahd,DaoudDunia,IbrahimBejjani,RiadChlela,ElieWaked,NajiJabbour,ElyseFahed,Sharbeleng2012-08-02T00:00:00Zoai:scielo:S0004-27492012000300006Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2012-08-02T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false |
dc.title.none.fl_str_mv |
Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis |
title |
Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis |
spellingShingle |
Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis Fadlallah,Ali Azithromycin/administration & dosage Blepharitis/drug therapy Chronic disease Ophthalmic solutions Meibomian glands |
title_short |
Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis |
title_full |
Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis |
title_fullStr |
Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis |
title_full_unstemmed |
Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis |
title_sort |
Azithromycin 1.5% ophthalmic solution: efficacy and treatment modalities in chronic blepharitis |
author |
Fadlallah,Ali |
author_facet |
Fadlallah,Ali Rami,Hala El Fahd,Daoud Dunia,Ibrahim Bejjani,Riad Chlela,Elie Waked,Naji Jabbour,Elyse Fahed,Sharbel |
author_role |
author |
author2 |
Rami,Hala El Fahd,Daoud Dunia,Ibrahim Bejjani,Riad Chlela,Elie Waked,Naji Jabbour,Elyse Fahed,Sharbel |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Fadlallah,Ali Rami,Hala El Fahd,Daoud Dunia,Ibrahim Bejjani,Riad Chlela,Elie Waked,Naji Jabbour,Elyse Fahed,Sharbel |
dc.subject.por.fl_str_mv |
Azithromycin/administration & dosage Blepharitis/drug therapy Chronic disease Ophthalmic solutions Meibomian glands |
topic |
Azithromycin/administration & dosage Blepharitis/drug therapy Chronic disease Ophthalmic solutions Meibomian glands |
description |
PURPOSE: To assess the efficacy of topical 1.5% azithromycin in the treatment of moderate to severe chronic blepharitis and to compare the efficacy of two different treatment modalities. METHODS: A randomized clinical trial included 67 patients with chronic anterior and/or posterior blepharitis, followed-up for 3 months. Signs and symptoms were graded according to severity. Patients were randomized into two groups: 33 patients in group I and 34 patients in group II. Group I patients were treated with topical 1.5% azithromycin twice a day for three days, and Group II patients were treated with topical 1.5% azithromycin twice a day for three days then at bedtime for the rest of the month. All patients were instructed to apply warm compresses and an eye-friendly soap twice daily. RESULTS: Patients in both groups tolerated the treatment with minimal irritation. A significant improvement in signs and symptoms was noted at the one week follow-up visit. Group II showed a more pronounced and longer-lasting improvement that persisted after three months of follow-up. CONCLUSION: Topical 1.5% azithromycin ophthalmic solution is an effective treatment option for chronic blepharitis. In moderate to severe blepharitis, a one month treatment is safe and shows better improvement than the three-day protocol with no significant relapse until three months of follow-up. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000300006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492012000300006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0004-27492012000300006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
publisher.none.fl_str_mv |
Conselho Brasileiro de Oftalmologia |
dc.source.none.fl_str_mv |
Arquivos Brasileiros de Oftalmologia v.75 n.3 2012 reponame:Arquivos brasileiros de oftalmologia (Online) instname:Conselho Brasileiro de Oftalmologia (CBO) instacron:CBO |
instname_str |
Conselho Brasileiro de Oftalmologia (CBO) |
instacron_str |
CBO |
institution |
CBO |
reponame_str |
Arquivos brasileiros de oftalmologia (Online) |
collection |
Arquivos brasileiros de oftalmologia (Online) |
repository.name.fl_str_mv |
Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO) |
repository.mail.fl_str_mv |
aboonline@cbo.com.br||abo@cbo.com.br |
_version_ |
1754209027270639616 |