Stability study of azithromycin in ophthalmic preparations

Detalhes bibliográficos
Autor(a) principal: Moreno, Andreia de Haro
Data de Publicação: 2009
Outros Autores: Silva, Maria Fernanda Conz da, Salgado, Hérida Regina Nunes [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1590/S1984-82502009000200005
http://hdl.handle.net/11449/243925
Resumo: A stability Study of azithromycin in ophthalmic preparations was developed by Submission to different types of light, temperature and pH, using the biodiffusion assay (cylinder 3 x 3) for the quantifications. Bacillus subtilis, ATCC 9372, was used as test organism. The used concentration range was of 50 to 200 mu g/mL. The Study demonstrated that the drug suffered degradation when submitted to the ultraviolet light, germicide light, solar luminosity, acid Solution, basic solution and hydrogen peroxide solution. The results were analyzed by the analysis of variance (ANOVA).
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spelling Stability study of azithromycin in ophthalmic preparationsAzithromycin/stability studyBioassayPhotodegradationOphthalmic preparationsA stability Study of azithromycin in ophthalmic preparations was developed by Submission to different types of light, temperature and pH, using the biodiffusion assay (cylinder 3 x 3) for the quantifications. Bacillus subtilis, ATCC 9372, was used as test organism. The used concentration range was of 50 to 200 mu g/mL. The Study demonstrated that the drug suffered degradation when submitted to the ultraviolet light, germicide light, solar luminosity, acid Solution, basic solution and hydrogen peroxide solution. The results were analyzed by the analysis of variance (ANOVA).O estudo de estabilidade de azitromicina em preparações oftálmicas foi realizado após exposição a diferentes tipos de luz, temperatura e pH, utilizando o método de difusão em ágar (cilindros 3 x 3) para as quantificações. A faixa de concentração foi de 50 a 200 µg/mL. O estudo demonstrou que o fármaco sofreu degradação quando submetido às luzes ultravioleta, germicida e solar, e a soluções ácida, alcalina e de peróxido de hidrogênio. Os resultados foram analisados através da análise da variância (ANOVA).Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Programa de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP (PADC)Department of Drugs and Medicines School of Pharmaceutical Sciences University of São Paulo StateUniv São Paulo State, Dept Drugs & Med, Fac Pharmaceut Sci, UNESP,Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, BrazilUniv São Paulo State, Dept Drugs & Med, Fac Pharmaceut Sci, UNESP,Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, BrazilUniversidade de São Paulo (USP), Conjunto QuimicasUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Moreno, Andreia de HaroSilva, Maria Fernanda Conz daSalgado, Hérida Regina Nunes [UNESP]2022-04-29T08:44:14Z2014-05-20T13:24:51Z2022-04-29T08:44:14Z2014-05-20T13:24:51Z2009-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article219-226application/pdfhttp://dx.doi.org/10.1590/S1984-82502009000200005Brazilian Journal of Pharmaceutical Sciences, v. 45, n. 2, p. 219-226, 2009.1984-82502175-9790http://hdl.handle.net/11449/24392510.1590/S1984-82502009000200005S1984-82502009000200005WOS:0002696539000052-s2.0-76149119801S1984-82502009000200005-en.pdfScopusWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Pharmaceutical Sciences0.4830,214info:eu-repo/semantics/openAccess2024-06-24T13:45:39Zoai:repositorio.unesp.br:11449/243925Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:06:05.202708Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Stability study of azithromycin in ophthalmic preparations
title Stability study of azithromycin in ophthalmic preparations
spellingShingle Stability study of azithromycin in ophthalmic preparations
Moreno, Andreia de Haro
Azithromycin/stability study
Bioassay
Photodegradation
Ophthalmic preparations
title_short Stability study of azithromycin in ophthalmic preparations
title_full Stability study of azithromycin in ophthalmic preparations
title_fullStr Stability study of azithromycin in ophthalmic preparations
title_full_unstemmed Stability study of azithromycin in ophthalmic preparations
title_sort Stability study of azithromycin in ophthalmic preparations
author Moreno, Andreia de Haro
author_facet Moreno, Andreia de Haro
Silva, Maria Fernanda Conz da
Salgado, Hérida Regina Nunes [UNESP]
author_role author
author2 Silva, Maria Fernanda Conz da
Salgado, Hérida Regina Nunes [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Moreno, Andreia de Haro
Silva, Maria Fernanda Conz da
Salgado, Hérida Regina Nunes [UNESP]
dc.subject.por.fl_str_mv Azithromycin/stability study
Bioassay
Photodegradation
Ophthalmic preparations
topic Azithromycin/stability study
Bioassay
Photodegradation
Ophthalmic preparations
description A stability Study of azithromycin in ophthalmic preparations was developed by Submission to different types of light, temperature and pH, using the biodiffusion assay (cylinder 3 x 3) for the quantifications. Bacillus subtilis, ATCC 9372, was used as test organism. The used concentration range was of 50 to 200 mu g/mL. The Study demonstrated that the drug suffered degradation when submitted to the ultraviolet light, germicide light, solar luminosity, acid Solution, basic solution and hydrogen peroxide solution. The results were analyzed by the analysis of variance (ANOVA).
publishDate 2009
dc.date.none.fl_str_mv 2009-04-01
2014-05-20T13:24:51Z
2014-05-20T13:24:51Z
2022-04-29T08:44:14Z
2022-04-29T08:44:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1984-82502009000200005
Brazilian Journal of Pharmaceutical Sciences, v. 45, n. 2, p. 219-226, 2009.
1984-8250
2175-9790
http://hdl.handle.net/11449/243925
10.1590/S1984-82502009000200005
S1984-82502009000200005
WOS:000269653900005
2-s2.0-76149119801
S1984-82502009000200005-en.pdf
url http://dx.doi.org/10.1590/S1984-82502009000200005
http://hdl.handle.net/11449/243925
identifier_str_mv Brazilian Journal of Pharmaceutical Sciences, v. 45, n. 2, p. 219-226, 2009.
1984-8250
2175-9790
10.1590/S1984-82502009000200005
S1984-82502009000200005
WOS:000269653900005
2-s2.0-76149119801
S1984-82502009000200005-en.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences
0.483
0,214
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 219-226
application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo (USP), Conjunto Quimicas
publisher.none.fl_str_mv Universidade de São Paulo (USP), Conjunto Quimicas
dc.source.none.fl_str_mv Scopus
Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128894118658048

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