Optical coherence tomography angiography: microvascular alterations in diabetic eyes without diabetic retinopathy

Detalhes bibliográficos
Autor(a) principal: Agra,Cristiana Lumack do Monte
Data de Publicação: 2021
Outros Autores: Lira,Rodrigo Pessoa Cavalcanti, Pinheiro,Fernanda Galvão, Sá,Larissa Halley Soares e, Bravo Filho,Vasco Torres Fernandes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492021000200149
Resumo: ABSTRACT Purpose: To describe microvascular changes in the maculas of individuals with type 2 diabetes observed on optical coherence tomography angiography (OCTA) images. We compared the maculas of diabetic subjects without diabetic retinopathy with those of healthy subjects and correlated the findings with the clinical profiles of diabetic subjects. Methods: One eye each of 30 patients with diabetes and 30 healthy individuals were examined. The patients with diabetes underwent funduscopy, retinography, and fluorescein angiography to rule out retinopathy. All subjects underwent optical coherence tomography angiography of a macular area (6×6 mm2), and the foveal and parafoveal vascular densities were analyzed in the superficial and deep retinal vascular plexus. The foveal and parafoveal thicknesses, foveal avascular zone of the superficial plexus, and choriocapillaris flow area were also examined. The optical coherence tomography angiography results were compared between the two study groups and correlated with the following parameters: visual acuity, time since diabetes diagnosis, glycemic control, lipid profile, and renal function of patients with diabetes. Results: A minimal increase in the choriocapillaris flow area was observed in the patients with diabetes (mean area, 22.3 ± 4.6 mm2 in controls; 22.6 ± 3.9 mm2 in patients with diabetes) (p=0.017). No significant differences were observed between other optical coherence tomography angiography parameters analyzed in the two groups. Glycosylated hemoglobin and fasting blood glucose levels were significantly negatively correlated with the foveal vascular density of both plexuses; conversely, fasting blood glucose levels were positively correlated with the choriocapillaris flow area (p=0.034). The other clinical parameters were not correlated with the optical coherence tomography angiography findings. Conclusion: Optical coherence tomography angiography may not be the most appropriate tool for detecting preclinical changes in patients with diabetes, moreover, optical coherence tomography angiography; does not replace clinical examinations. Glycemic control should be the primary clinical parameter considered during retinopathy screening. Larger studies are necessary to confirm these findings.
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spelling Optical coherence tomography angiography: microvascular alterations in diabetic eyes without diabetic retinopathyAngiographyDiabetes mellitusDiabetic retinopathyDiagnostic imagingTomographpy, optical coherenceABSTRACT Purpose: To describe microvascular changes in the maculas of individuals with type 2 diabetes observed on optical coherence tomography angiography (OCTA) images. We compared the maculas of diabetic subjects without diabetic retinopathy with those of healthy subjects and correlated the findings with the clinical profiles of diabetic subjects. Methods: One eye each of 30 patients with diabetes and 30 healthy individuals were examined. The patients with diabetes underwent funduscopy, retinography, and fluorescein angiography to rule out retinopathy. All subjects underwent optical coherence tomography angiography of a macular area (6×6 mm2), and the foveal and parafoveal vascular densities were analyzed in the superficial and deep retinal vascular plexus. The foveal and parafoveal thicknesses, foveal avascular zone of the superficial plexus, and choriocapillaris flow area were also examined. The optical coherence tomography angiography results were compared between the two study groups and correlated with the following parameters: visual acuity, time since diabetes diagnosis, glycemic control, lipid profile, and renal function of patients with diabetes. Results: A minimal increase in the choriocapillaris flow area was observed in the patients with diabetes (mean area, 22.3 ± 4.6 mm2 in controls; 22.6 ± 3.9 mm2 in patients with diabetes) (p=0.017). No significant differences were observed between other optical coherence tomography angiography parameters analyzed in the two groups. Glycosylated hemoglobin and fasting blood glucose levels were significantly negatively correlated with the foveal vascular density of both plexuses; conversely, fasting blood glucose levels were positively correlated with the choriocapillaris flow area (p=0.034). The other clinical parameters were not correlated with the optical coherence tomography angiography findings. Conclusion: Optical coherence tomography angiography may not be the most appropriate tool for detecting preclinical changes in patients with diabetes, moreover, optical coherence tomography angiography; does not replace clinical examinations. Glycemic control should be the primary clinical parameter considered during retinopathy screening. Larger studies are necessary to confirm these findings.Conselho Brasileiro de Oftalmologia2021-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492021000200149Arquivos Brasileiros de Oftalmologia v.84 n.2 2021reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.5935/0004-2749.20210023info:eu-repo/semantics/openAccessAgra,Cristiana Lumack do MonteLira,Rodrigo Pessoa CavalcantiPinheiro,Fernanda GalvãoSá,Larissa Halley Soares eBravo Filho,Vasco Torres Fernandeseng2021-03-23T00:00:00Zoai:scielo:S0004-27492021000200149Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2021-03-23T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv Optical coherence tomography angiography: microvascular alterations in diabetic eyes without diabetic retinopathy
title Optical coherence tomography angiography: microvascular alterations in diabetic eyes without diabetic retinopathy
spellingShingle Optical coherence tomography angiography: microvascular alterations in diabetic eyes without diabetic retinopathy
Agra,Cristiana Lumack do Monte
Angiography
Diabetes mellitus
Diabetic retinopathy
Diagnostic imaging
Tomographpy, optical coherence
title_short Optical coherence tomography angiography: microvascular alterations in diabetic eyes without diabetic retinopathy
title_full Optical coherence tomography angiography: microvascular alterations in diabetic eyes without diabetic retinopathy
title_fullStr Optical coherence tomography angiography: microvascular alterations in diabetic eyes without diabetic retinopathy
title_full_unstemmed Optical coherence tomography angiography: microvascular alterations in diabetic eyes without diabetic retinopathy
title_sort Optical coherence tomography angiography: microvascular alterations in diabetic eyes without diabetic retinopathy
author Agra,Cristiana Lumack do Monte
author_facet Agra,Cristiana Lumack do Monte
Lira,Rodrigo Pessoa Cavalcanti
Pinheiro,Fernanda Galvão
Sá,Larissa Halley Soares e
Bravo Filho,Vasco Torres Fernandes
author_role author
author2 Lira,Rodrigo Pessoa Cavalcanti
Pinheiro,Fernanda Galvão
Sá,Larissa Halley Soares e
Bravo Filho,Vasco Torres Fernandes
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Agra,Cristiana Lumack do Monte
Lira,Rodrigo Pessoa Cavalcanti
Pinheiro,Fernanda Galvão
Sá,Larissa Halley Soares e
Bravo Filho,Vasco Torres Fernandes
dc.subject.por.fl_str_mv Angiography
Diabetes mellitus
Diabetic retinopathy
Diagnostic imaging
Tomographpy, optical coherence
topic Angiography
Diabetes mellitus
Diabetic retinopathy
Diagnostic imaging
Tomographpy, optical coherence
description ABSTRACT Purpose: To describe microvascular changes in the maculas of individuals with type 2 diabetes observed on optical coherence tomography angiography (OCTA) images. We compared the maculas of diabetic subjects without diabetic retinopathy with those of healthy subjects and correlated the findings with the clinical profiles of diabetic subjects. Methods: One eye each of 30 patients with diabetes and 30 healthy individuals were examined. The patients with diabetes underwent funduscopy, retinography, and fluorescein angiography to rule out retinopathy. All subjects underwent optical coherence tomography angiography of a macular area (6×6 mm2), and the foveal and parafoveal vascular densities were analyzed in the superficial and deep retinal vascular plexus. The foveal and parafoveal thicknesses, foveal avascular zone of the superficial plexus, and choriocapillaris flow area were also examined. The optical coherence tomography angiography results were compared between the two study groups and correlated with the following parameters: visual acuity, time since diabetes diagnosis, glycemic control, lipid profile, and renal function of patients with diabetes. Results: A minimal increase in the choriocapillaris flow area was observed in the patients with diabetes (mean area, 22.3 ± 4.6 mm2 in controls; 22.6 ± 3.9 mm2 in patients with diabetes) (p=0.017). No significant differences were observed between other optical coherence tomography angiography parameters analyzed in the two groups. Glycosylated hemoglobin and fasting blood glucose levels were significantly negatively correlated with the foveal vascular density of both plexuses; conversely, fasting blood glucose levels were positively correlated with the choriocapillaris flow area (p=0.034). The other clinical parameters were not correlated with the optical coherence tomography angiography findings. Conclusion: Optical coherence tomography angiography may not be the most appropriate tool for detecting preclinical changes in patients with diabetes, moreover, optical coherence tomography angiography; does not replace clinical examinations. Glycemic control should be the primary clinical parameter considered during retinopathy screening. Larger studies are necessary to confirm these findings.
publishDate 2021
dc.date.none.fl_str_mv 2021-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.relation.none.fl_str_mv 10.5935/0004-2749.20210023
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dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.84 n.2 2021
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
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reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
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