The role of optical coherence tomography angiography to detect early microvascular changes in diabetic retinopathy: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.21/13865 |
Resumo: | Purpose To evaluate quantitative parafoveal microvascular changes using Optical Coherence Tomography Angiography (OCTA) by comparing the area of the foveal avascular zone (FAZ) and vessel density (VD) between non-diabetic controls and patients with different levels of Diabetic Retinopathy (DR). Methods A systematic review was performed according to the recommendations of the "Cochrane Handbook for Systematic Reviews of Interventions" and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Three electronic databases including PubMed, Web of Science, and Cochrane Library were systematically retrieved by using key terms with Boolean operators. The data extracted from each study included: first author, year of publication, study design, sample size, and participant characteristics (mean age, type of diabetes mellitus, and mean duration of diabetic disease). Outcome variables included: VD and area of FAZ, in superficial and deep capillary plexuses of parafovea. Results 355 articles were identified from our search of databases and 10 studies were included in this systematic review. Patients with diabetes with or without clinical signs of DR have a significantly enlarged area of FAZ and decreased parafoveal VD compared to healthy controls, as well as an association between these microvascular changes and worsening DR. Conclusion OCTA can provide valuable information about early and subtle microvascular changes of parafoveal capillary plexuses in patients with diabetes and can identify preclinical DR before the manifestation of clinically apparent retinopathy. The non-invasive nature of OCTA allows routine imaging of the retinal vasculature, so this approach may be a promising tool for screening programs of DR. |
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The role of optical coherence tomography angiography to detect early microvascular changes in diabetic retinopathy: a systematic reviewOrthopticsDiabetic retinopathyOptical coherence tomography angiographyMicrovascular changesRetinal imagingPurpose To evaluate quantitative parafoveal microvascular changes using Optical Coherence Tomography Angiography (OCTA) by comparing the area of the foveal avascular zone (FAZ) and vessel density (VD) between non-diabetic controls and patients with different levels of Diabetic Retinopathy (DR). Methods A systematic review was performed according to the recommendations of the "Cochrane Handbook for Systematic Reviews of Interventions" and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Three electronic databases including PubMed, Web of Science, and Cochrane Library were systematically retrieved by using key terms with Boolean operators. The data extracted from each study included: first author, year of publication, study design, sample size, and participant characteristics (mean age, type of diabetes mellitus, and mean duration of diabetic disease). Outcome variables included: VD and area of FAZ, in superficial and deep capillary plexuses of parafovea. Results 355 articles were identified from our search of databases and 10 studies were included in this systematic review. Patients with diabetes with or without clinical signs of DR have a significantly enlarged area of FAZ and decreased parafoveal VD compared to healthy controls, as well as an association between these microvascular changes and worsening DR. Conclusion OCTA can provide valuable information about early and subtle microvascular changes of parafoveal capillary plexuses in patients with diabetes and can identify preclinical DR before the manifestation of clinically apparent retinopathy. The non-invasive nature of OCTA allows routine imaging of the retinal vasculature, so this approach may be a promising tool for screening programs of DR.RCIPLPalma, FilipaCamacho, Pedro2021-10-12T10:47:07Z2021-092021-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/13865engPalma F, Camacho P. The role of optical coherence tomography angiography to detect early microvascular changes in diabetic retinopathy: a systematic review. J Diabetes Metab Disord. 2021;20:1957-74.10.1007/s40200-021-00886-0info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:09:17Zoai:repositorio.ipl.pt:10400.21/13865Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:21:44.558468Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The role of optical coherence tomography angiography to detect early microvascular changes in diabetic retinopathy: a systematic review |
title |
The role of optical coherence tomography angiography to detect early microvascular changes in diabetic retinopathy: a systematic review |
spellingShingle |
The role of optical coherence tomography angiography to detect early microvascular changes in diabetic retinopathy: a systematic review Palma, Filipa Orthoptics Diabetic retinopathy Optical coherence tomography angiography Microvascular changes Retinal imaging |
title_short |
The role of optical coherence tomography angiography to detect early microvascular changes in diabetic retinopathy: a systematic review |
title_full |
The role of optical coherence tomography angiography to detect early microvascular changes in diabetic retinopathy: a systematic review |
title_fullStr |
The role of optical coherence tomography angiography to detect early microvascular changes in diabetic retinopathy: a systematic review |
title_full_unstemmed |
The role of optical coherence tomography angiography to detect early microvascular changes in diabetic retinopathy: a systematic review |
title_sort |
The role of optical coherence tomography angiography to detect early microvascular changes in diabetic retinopathy: a systematic review |
author |
Palma, Filipa |
author_facet |
Palma, Filipa Camacho, Pedro |
author_role |
author |
author2 |
Camacho, Pedro |
author2_role |
author |
dc.contributor.none.fl_str_mv |
RCIPL |
dc.contributor.author.fl_str_mv |
Palma, Filipa Camacho, Pedro |
dc.subject.por.fl_str_mv |
Orthoptics Diabetic retinopathy Optical coherence tomography angiography Microvascular changes Retinal imaging |
topic |
Orthoptics Diabetic retinopathy Optical coherence tomography angiography Microvascular changes Retinal imaging |
description |
Purpose To evaluate quantitative parafoveal microvascular changes using Optical Coherence Tomography Angiography (OCTA) by comparing the area of the foveal avascular zone (FAZ) and vessel density (VD) between non-diabetic controls and patients with different levels of Diabetic Retinopathy (DR). Methods A systematic review was performed according to the recommendations of the "Cochrane Handbook for Systematic Reviews of Interventions" and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Three electronic databases including PubMed, Web of Science, and Cochrane Library were systematically retrieved by using key terms with Boolean operators. The data extracted from each study included: first author, year of publication, study design, sample size, and participant characteristics (mean age, type of diabetes mellitus, and mean duration of diabetic disease). Outcome variables included: VD and area of FAZ, in superficial and deep capillary plexuses of parafovea. Results 355 articles were identified from our search of databases and 10 studies were included in this systematic review. Patients with diabetes with or without clinical signs of DR have a significantly enlarged area of FAZ and decreased parafoveal VD compared to healthy controls, as well as an association between these microvascular changes and worsening DR. Conclusion OCTA can provide valuable information about early and subtle microvascular changes of parafoveal capillary plexuses in patients with diabetes and can identify preclinical DR before the manifestation of clinically apparent retinopathy. The non-invasive nature of OCTA allows routine imaging of the retinal vasculature, so this approach may be a promising tool for screening programs of DR. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-12T10:47:07Z 2021-09 2021-09-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.21/13865 |
url |
http://hdl.handle.net/10400.21/13865 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Palma F, Camacho P. The role of optical coherence tomography angiography to detect early microvascular changes in diabetic retinopathy: a systematic review. J Diabetes Metab Disord. 2021;20:1957-74. 10.1007/s40200-021-00886-0 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133488982523904 |