Biological modulation of corneal epithelial wound healing

Detalhes bibliográficos
Autor(a) principal: Loureiro,Renata Ruoco
Data de Publicação: 2019
Outros Autores: Gomes,José Álvaro Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos brasileiros de oftalmologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000100078
Resumo: ABSTRACT The transparency and maintenance of corneal epithelial integrity are essential for its optical properties and, to preserve these characteristics, the epithelium undergoes continuous renewal. This renewal depends on the control of cell proliferation and differentiation mediated by mitogenic factors responsible for increasing mitoses and stimulating cellular migration. Cell-cell communication plays a pivotal role in epithelial healing process, and several cytokines and growth factors are involved in this process. Understanding the cross-talk and paracrine effects of these cytokines and growth factors released can help in the search for new therapeutic strategies to treat ocular surface diseases.
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spelling Biological modulation of corneal epithelial wound healingEndothelium, cornealCytokinesWound healingCell proliferationABSTRACT The transparency and maintenance of corneal epithelial integrity are essential for its optical properties and, to preserve these characteristics, the epithelium undergoes continuous renewal. This renewal depends on the control of cell proliferation and differentiation mediated by mitogenic factors responsible for increasing mitoses and stimulating cellular migration. Cell-cell communication plays a pivotal role in epithelial healing process, and several cytokines and growth factors are involved in this process. Understanding the cross-talk and paracrine effects of these cytokines and growth factors released can help in the search for new therapeutic strategies to treat ocular surface diseases.Conselho Brasileiro de Oftalmologia2019-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000100078Arquivos Brasileiros de Oftalmologia v.82 n.1 2019reponame:Arquivos brasileiros de oftalmologia (Online)instname:Conselho Brasileiro de Oftalmologia (CBO)instacron:CBO10.5935/0004-2749.20190016info:eu-repo/semantics/openAccessLoureiro,Renata RuocoGomes,José Álvaro Pereiraeng2019-01-10T00:00:00Zoai:scielo:S0004-27492019000100078Revistahttp://aboonline.org.br/https://old.scielo.br/oai/scielo-oai.phpaboonline@cbo.com.br||abo@cbo.com.br1678-29250004-2749opendoar:2019-01-10T00:00Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)false
dc.title.none.fl_str_mv Biological modulation of corneal epithelial wound healing
title Biological modulation of corneal epithelial wound healing
spellingShingle Biological modulation of corneal epithelial wound healing
Loureiro,Renata Ruoco
Endothelium, corneal
Cytokines
Wound healing
Cell proliferation
title_short Biological modulation of corneal epithelial wound healing
title_full Biological modulation of corneal epithelial wound healing
title_fullStr Biological modulation of corneal epithelial wound healing
title_full_unstemmed Biological modulation of corneal epithelial wound healing
title_sort Biological modulation of corneal epithelial wound healing
author Loureiro,Renata Ruoco
author_facet Loureiro,Renata Ruoco
Gomes,José Álvaro Pereira
author_role author
author2 Gomes,José Álvaro Pereira
author2_role author
dc.contributor.author.fl_str_mv Loureiro,Renata Ruoco
Gomes,José Álvaro Pereira
dc.subject.por.fl_str_mv Endothelium, corneal
Cytokines
Wound healing
Cell proliferation
topic Endothelium, corneal
Cytokines
Wound healing
Cell proliferation
description ABSTRACT The transparency and maintenance of corneal epithelial integrity are essential for its optical properties and, to preserve these characteristics, the epithelium undergoes continuous renewal. This renewal depends on the control of cell proliferation and differentiation mediated by mitogenic factors responsible for increasing mitoses and stimulating cellular migration. Cell-cell communication plays a pivotal role in epithelial healing process, and several cytokines and growth factors are involved in this process. Understanding the cross-talk and paracrine effects of these cytokines and growth factors released can help in the search for new therapeutic strategies to treat ocular surface diseases.
publishDate 2019
dc.date.none.fl_str_mv 2019-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000100078
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019000100078
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.5935/0004-2749.20190016
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Oftalmologia v.82 n.1 2019
reponame:Arquivos brasileiros de oftalmologia (Online)
instname:Conselho Brasileiro de Oftalmologia (CBO)
instacron:CBO
instname_str Conselho Brasileiro de Oftalmologia (CBO)
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institution CBO
reponame_str Arquivos brasileiros de oftalmologia (Online)
collection Arquivos brasileiros de oftalmologia (Online)
repository.name.fl_str_mv Arquivos brasileiros de oftalmologia (Online) - Conselho Brasileiro de Oftalmologia (CBO)
repository.mail.fl_str_mv aboonline@cbo.com.br||abo@cbo.com.br
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