Parasitological and histological aspects of Holochilus sciureus naturally infected by Schistosoma mansoni

• Autor(a) principal: Silva-Souza,Nêuton da
• Data de Publicação: 2019
• Outros Autores: Silva,Ana Patrícia de Carvalho da, Oliveira,Renata Mondego de, Lira,Maria Gabriela Sampaio, Nogueira,Ranielly Araújo, Penha-Silva,Tatiane Aranha da, Melo,Solange de Araújo, Andrade,Fábio Henrique Evangelista de, Santos-Ribeiro,Larissa Sarmento dos, Carvalho Neta,Alcina Vieira de, Abreu-Silva,Ana Lucia
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Revista Brasileira de Parasitologia Veterinária (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612019000400769
• topic: Rodent; schistosomiasis; histopathology; host

Abstract Schistosomiasis is a neglected disease that affects millions of people around the world, being common in the state of Maranhão. A total of 225 rodents of the Holochilus sciureus species from the Western Lowland Maranhão were studied, of which 144 animals (64%) exhibited Schistosoma eggs in their feces samples. Macroscopic lesions characterized as well-defined whitish areas on the liver and spleen surfaces were observed. Histopathological examination revealed multifocal granulomas in the esophagus, liver, spleen, pancreas and duodenum, with structures compatible with Schistosoma mansoni eggs, as well as severe hepatic micro-vacuolar degeneration, multifocal and coalescent, with proliferation of random bile ducts and associated epithelial hyperplasia to areas of fibrosis. Adult forms of the parasite were observed in the blood vessels of the portal space. The lungs exhibited moderate and diffuse interstitial pneumonia with intralesional S. mansoni eggs. In the kidneys, hyaline cylinders were observed in the pelvis and diffuse hemorrhage. In conclusion, H. sciureus displays a pathological picture similar to human being. This rodent plays a role as sentinel in Baixada Maranhense.