Cardiac markers: profile in rats experimentally infected with Toxocara canis
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Revista Brasileira de Parasitologia Veterinária (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000300020 |
Resumo: | The aim of this study was to evaluate the profile of the enzymes creatine kinase (CK), creatine kinase MB (CK-MB) and lactate dehydrogenase (LDH) in Wistar rats infected with 250 (GI, n = 24) or 1000 (GII, n = 24) Toxocara canis eggs. Animals were evaluated on days 7, 15, 30, 60, 120 and 180 post-infection (DPI). Only the GI rats showed an increase in CK and CK-MB, at 15 and 30 DPI, respectively. Anti-Toxocara spp. antibodies were detected by ELISA in infected animals. Despite of the presence of eosinophilic infiltrate in the heart of three infected animals, none larva was recovered from the organ neither by acid digestion nor by Baermann procedure. Eosinophilia was observed in both groups but there was no significant difference in the eosinophil counts between GI and GII (p = 0.2239). It is possible to consider that cardiac lesion is an eventual finding in murine model for toxocariasis. |
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Cardiac markers: profile in rats experimentally infected with Toxocara canisToxocariasiscardiac lesionscardiac biomarkersThe aim of this study was to evaluate the profile of the enzymes creatine kinase (CK), creatine kinase MB (CK-MB) and lactate dehydrogenase (LDH) in Wistar rats infected with 250 (GI, n = 24) or 1000 (GII, n = 24) Toxocara canis eggs. Animals were evaluated on days 7, 15, 30, 60, 120 and 180 post-infection (DPI). Only the GI rats showed an increase in CK and CK-MB, at 15 and 30 DPI, respectively. Anti-Toxocara spp. antibodies were detected by ELISA in infected animals. Despite of the presence of eosinophilic infiltrate in the heart of three infected animals, none larva was recovered from the organ neither by acid digestion nor by Baermann procedure. Eosinophilia was observed in both groups but there was no significant difference in the eosinophil counts between GI and GII (p = 0.2239). It is possible to consider that cardiac lesion is an eventual finding in murine model for toxocariasis.Colégio Brasileiro de Parasitologia Veterinária2012-09-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000300020Revista Brasileira de Parasitologia Veterinária v.21 n.3 2012reponame:Revista Brasileira de Parasitologia Veterinária (Online)instname:Colégio Brasileiro de Parasitologia Veterinária (CBPV)instacron:CBPV10.1590/S1984-29612012000300020info:eu-repo/semantics/openAccessLaposy,Cecília BragaFreitas,Selma de Bastos ZambelliLouzada,André NogueiraRubinsky-Elefant,GuitaGiuffrida,RogérioNogueira,Rosa Maria BariliSantarém,Vamilton Alvareseng2012-10-11T00:00:00Zoai:scielo:S1984-29612012000300020Revistahttp://www.scielo.br/scielo.php?script=sci_serial&lng=pt&pid=1984-2961https://old.scielo.br/oai/scielo-oai.php||zacariascbpv@fcav.unesp.br1984-29610103-846Xopendoar:2012-10-11T00:00Revista Brasileira de Parasitologia Veterinária (Online) - Colégio Brasileiro de Parasitologia Veterinária (CBPV)false |
dc.title.none.fl_str_mv |
Cardiac markers: profile in rats experimentally infected with Toxocara canis |
title |
Cardiac markers: profile in rats experimentally infected with Toxocara canis |
spellingShingle |
Cardiac markers: profile in rats experimentally infected with Toxocara canis Laposy,Cecília Braga Toxocariasis cardiac lesions cardiac biomarkers |
title_short |
Cardiac markers: profile in rats experimentally infected with Toxocara canis |
title_full |
Cardiac markers: profile in rats experimentally infected with Toxocara canis |
title_fullStr |
Cardiac markers: profile in rats experimentally infected with Toxocara canis |
title_full_unstemmed |
Cardiac markers: profile in rats experimentally infected with Toxocara canis |
title_sort |
Cardiac markers: profile in rats experimentally infected with Toxocara canis |
author |
Laposy,Cecília Braga |
author_facet |
Laposy,Cecília Braga Freitas,Selma de Bastos Zambelli Louzada,André Nogueira Rubinsky-Elefant,Guita Giuffrida,Rogério Nogueira,Rosa Maria Barili Santarém,Vamilton Alvares |
author_role |
author |
author2 |
Freitas,Selma de Bastos Zambelli Louzada,André Nogueira Rubinsky-Elefant,Guita Giuffrida,Rogério Nogueira,Rosa Maria Barili Santarém,Vamilton Alvares |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Laposy,Cecília Braga Freitas,Selma de Bastos Zambelli Louzada,André Nogueira Rubinsky-Elefant,Guita Giuffrida,Rogério Nogueira,Rosa Maria Barili Santarém,Vamilton Alvares |
dc.subject.por.fl_str_mv |
Toxocariasis cardiac lesions cardiac biomarkers |
topic |
Toxocariasis cardiac lesions cardiac biomarkers |
description |
The aim of this study was to evaluate the profile of the enzymes creatine kinase (CK), creatine kinase MB (CK-MB) and lactate dehydrogenase (LDH) in Wistar rats infected with 250 (GI, n = 24) or 1000 (GII, n = 24) Toxocara canis eggs. Animals were evaluated on days 7, 15, 30, 60, 120 and 180 post-infection (DPI). Only the GI rats showed an increase in CK and CK-MB, at 15 and 30 DPI, respectively. Anti-Toxocara spp. antibodies were detected by ELISA in infected animals. Despite of the presence of eosinophilic infiltrate in the heart of three infected animals, none larva was recovered from the organ neither by acid digestion nor by Baermann procedure. Eosinophilia was observed in both groups but there was no significant difference in the eosinophil counts between GI and GII (p = 0.2239). It is possible to consider that cardiac lesion is an eventual finding in murine model for toxocariasis. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000300020 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1984-29612012000300020 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1984-29612012000300020 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Parasitologia Veterinária |
publisher.none.fl_str_mv |
Colégio Brasileiro de Parasitologia Veterinária |
dc.source.none.fl_str_mv |
Revista Brasileira de Parasitologia Veterinária v.21 n.3 2012 reponame:Revista Brasileira de Parasitologia Veterinária (Online) instname:Colégio Brasileiro de Parasitologia Veterinária (CBPV) instacron:CBPV |
instname_str |
Colégio Brasileiro de Parasitologia Veterinária (CBPV) |
instacron_str |
CBPV |
institution |
CBPV |
reponame_str |
Revista Brasileira de Parasitologia Veterinária (Online) |
collection |
Revista Brasileira de Parasitologia Veterinária (Online) |
repository.name.fl_str_mv |
Revista Brasileira de Parasitologia Veterinária (Online) - Colégio Brasileiro de Parasitologia Veterinária (CBPV) |
repository.mail.fl_str_mv |
||zacariascbpv@fcav.unesp.br |
_version_ |
1754208914399821824 |