Severe Kala-azar and seric level of IL-6: case reports

• Autor(a) principal: Brito, Gilmara da Rocha
• Data de Publicação: 2020
• Outros Autores: Marreiros, Aécio da Silva, Araujo, Izael Francisco de Brito, da Silva Júnior, Raimundo Gerônimo, Sene, Ingridi de Souza, Braz, Débora Cavalcante
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Journal of Health & Biological Sciences
• DOI: 10.12662/2317-3076jhbs.v8i1.3035.p1-4.2020
• Texto Completo: https://periodicos.unichristus.edu.br/jhbs/article/view/3035
• topic: Ciências da Sáude; Calazar, Interleucina-6, Coinfecção, Hepatite B; Calazar

Introduction: IL-6 cytokine participates in the inflammatory process of systemic leishmaniasis and elevated levels are associated with active disease. Case reports: Three patients with different age groups and different severity scores, above 4 were reported, and IL-6 plasma concentrations and their association with disease severity were observed. Conclusion: Analysis suggests that only the score, has no sensitivity to classify, among others critically ill patients, those with imminent risk of death. IL-6 concentrations can allow this differentiation, considering that only fatal case, HBV/Leishmania coinfection, presented expressively higher level of the cytokine concentration.