Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/59212 |
Resumo: | Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil / University of Oslo. Institute of Basic Medical Sciences. Department of Nutrition, Oslo, Norway. |
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Costa-Amaral, Isabele C.Carvalho, Leandro V. B.Santos, Marcus Vinicius C.Valente, DanielPereira, Angélica C.Figueiredo, Victor O.Souza, Juliana Mendonça deCastro, Vinicio S.Trancoso, Maria de FátimaFonseca, Antônio Sérgio A.Milagres, Vanessa G.Mendes, Michele P. R.Paiva, Maria José N.André, Leiliane C.Borges, Renato M.Menezes, Marco Antônio C.Alves, Sérgio R.Gonçalves, Eline S.Sisenando, Herbert AryPerini, Jamila A.Oliveira, Mônica S.Moura-Correa, Maria JulianaTeixeira, Liliane R.Collins, Andrew R.Mattos, Rita de Cássia O. C.Sarcinelli, Paula N.Larentis, Ariane L.2023-06-27T23:09:07Z2023-06-27T23:09:07Z2019COSTA-AMARAL, Isabele C. et al. Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene. International Journal of Environmental Research and Public Health, v. 16, n. 12, p. 1-32, Jun. 2019.1661-7827https://www.arca.fiocruz.br/handle/icict/5921210.3390/ijerph161222401660-4601engMDPIEnvironmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzeneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil / University of Oslo. Institute of Basic Medical Sciences. Department of Nutrition, Oslo, Norway.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Faculdade de Farmácia. Departamento de Análises Clínicas e Toxicológicas. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio Grande do Norte. Centro de Ciências da Saúde. Departamento de Análises Clínicas e Toxicológicas. Natal, RN, Brasil.Centro Universitário Estadual da Zona Oeste. Unidade de Farmácia. Laboratório de Pesquisa de Ciências Farmacêuticas. Rio de Janeiro, RJ, Brasil.Comissão Nacional de Energia Nuclear. Instituto de Radioproteção e Dosimetria. Departamento de Dosimetria. Laboratório de Biodosimetria. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil / Prefeitura Municipal de Porto Alegre. Secretaria Municipal de Saúde. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.University of Oslo. Institute of Basic Medical Sciences. Department of Nutrition. Oslo, Norway.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil.Environmental and occupational exposure to benzene from fuels is a major cause for concern for national and international authorities, as benzene is a known carcinogen in humans and there is no safe limit for exposure to carcinogens. The objective of this study was to evaluate the genotoxic effects of chronic occupational exposure to benzene among two groups of workers: filling station workers (Group I) and security guards working at vehicles entrances (Group II), both on the same busy highway in Rio de Janeiro, Brazil. Sociodemographic data on the workers were evaluated; the concentration of benzene/toluene (B/T) in atmospheric air and individual trans,trans-muconic acid (ttMA) and S-phenylmercapturic acid (S-PMA) were measured; oxidative stress was analyzed by catalase (CAT), glutathione S-transferase (GST), superoxide dismutase (SOD), thiol groups (THIOL) and malondialdehyde (MDA); genotoxicity was measured by metaphases with chromosomal abnormalities (MCA) and nuclear abnormalities, comet assay using the enzyme formamidopyrimidine DNA glycosylase (C-FPG), and methylation of repetitive element LINE-1, CDKN2B and KLF6 genes. Eighty-six workers participated: 51 from Group I and 35 from Group II. The B/T ratio was similar for both groups, but Group I had greater oscillation of benzene concentrations because of their work activities. No differences in ttMA and S-PMA, and no clinical changes were found between both groups, but linearity was observed between leukocyte count and ttMA; and 15% of workers had leukocyte counts less than 4.5 × 109 cells L-1, demanding close worker's attention. No differences were observed between the two groups for THIOL, MDA, MCA, or nuclear abnormalities. A multiple linear relationship was obtained for the biomarkers MCA and C-FPG. A significant correlation was found between length of time in current job and the biomarkers C-FPG, MCA, GST, and MDA. Although both populations had chronic exposure to benzene, the filling station workers were exposed to higher concentrations of benzene during their work activities, indicating an increased risk of DNA damage.BenzeneOccupational and Environmental HealthChronic ExposureOxidative StressGenotoxicity and Formamidopyrimidine DNA-glycosylaseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Costa-Amaral_Isabele_etal_ENSP_2019.pdfve_Costa-Amaral_Isabele_etal_ENSP_2019.pdfapplication/pdf1986131https://www.arca.fiocruz.br/bitstream/icict/59212/2/ve_Costa-Amaral_Isabele_etal_ENSP_2019.pdfa7fccc164354106356be042eca05a15eMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/59212/1/license.txt5a560609d32a3863062d77ff32785d58MD51icict/592122023-06-27 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dc.title.en_US.fl_str_mv |
Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene |
title |
Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene |
spellingShingle |
Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene Costa-Amaral, Isabele C. Benzene Occupational and Environmental Health Chronic Exposure Oxidative Stress Genotoxicity and Formamidopyrimidine DNA-glycosylase |
title_short |
Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene |
title_full |
Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene |
title_fullStr |
Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene |
title_full_unstemmed |
Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene |
title_sort |
Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene |
author |
Costa-Amaral, Isabele C. |
author_facet |
Costa-Amaral, Isabele C. Carvalho, Leandro V. B. Santos, Marcus Vinicius C. Valente, Daniel Pereira, Angélica C. Figueiredo, Victor O. Souza, Juliana Mendonça de Castro, Vinicio S. Trancoso, Maria de Fátima Fonseca, Antônio Sérgio A. Milagres, Vanessa G. Mendes, Michele P. R. Paiva, Maria José N. André, Leiliane C. Borges, Renato M. Menezes, Marco Antônio C. Alves, Sérgio R. Gonçalves, Eline S. Sisenando, Herbert Ary Perini, Jamila A. Oliveira, Mônica S. Moura-Correa, Maria Juliana Teixeira, Liliane R. Collins, Andrew R. Mattos, Rita de Cássia O. C. Sarcinelli, Paula N. Larentis, Ariane L. |
author_role |
author |
author2 |
Carvalho, Leandro V. B. Santos, Marcus Vinicius C. Valente, Daniel Pereira, Angélica C. Figueiredo, Victor O. Souza, Juliana Mendonça de Castro, Vinicio S. Trancoso, Maria de Fátima Fonseca, Antônio Sérgio A. Milagres, Vanessa G. Mendes, Michele P. R. Paiva, Maria José N. André, Leiliane C. Borges, Renato M. Menezes, Marco Antônio C. Alves, Sérgio R. Gonçalves, Eline S. Sisenando, Herbert Ary Perini, Jamila A. Oliveira, Mônica S. Moura-Correa, Maria Juliana Teixeira, Liliane R. Collins, Andrew R. Mattos, Rita de Cássia O. C. Sarcinelli, Paula N. Larentis, Ariane L. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Costa-Amaral, Isabele C. Carvalho, Leandro V. B. Santos, Marcus Vinicius C. Valente, Daniel Pereira, Angélica C. Figueiredo, Victor O. Souza, Juliana Mendonça de Castro, Vinicio S. Trancoso, Maria de Fátima Fonseca, Antônio Sérgio A. Milagres, Vanessa G. Mendes, Michele P. R. Paiva, Maria José N. André, Leiliane C. Borges, Renato M. Menezes, Marco Antônio C. Alves, Sérgio R. Gonçalves, Eline S. Sisenando, Herbert Ary Perini, Jamila A. Oliveira, Mônica S. Moura-Correa, Maria Juliana Teixeira, Liliane R. Collins, Andrew R. Mattos, Rita de Cássia O. C. Sarcinelli, Paula N. Larentis, Ariane L. |
dc.subject.en.en_US.fl_str_mv |
Benzene Occupational and Environmental Health Chronic Exposure Oxidative Stress Genotoxicity and Formamidopyrimidine DNA-glycosylase |
topic |
Benzene Occupational and Environmental Health Chronic Exposure Oxidative Stress Genotoxicity and Formamidopyrimidine DNA-glycosylase |
description |
Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Centro de Estudos da Saúde do Trabalhador e Ecologia Humana. Rio de Janeiro, RJ, Brasil / University of Oslo. Institute of Basic Medical Sciences. Department of Nutrition, Oslo, Norway. |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019 |
dc.date.accessioned.fl_str_mv |
2023-06-27T23:09:07Z |
dc.date.available.fl_str_mv |
2023-06-27T23:09:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
COSTA-AMARAL, Isabele C. et al. Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene. International Journal of Environmental Research and Public Health, v. 16, n. 12, p. 1-32, Jun. 2019. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/59212 |
dc.identifier.issn.en_US.fl_str_mv |
1661-7827 |
dc.identifier.doi.none.fl_str_mv |
10.3390/ijerph16122240 |
dc.identifier.eissn.none.fl_str_mv |
1660-4601 |
identifier_str_mv |
COSTA-AMARAL, Isabele C. et al. Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene. International Journal of Environmental Research and Public Health, v. 16, n. 12, p. 1-32, Jun. 2019. 1661-7827 10.3390/ijerph16122240 1660-4601 |
url |
https://www.arca.fiocruz.br/handle/icict/59212 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
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MDPI |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Fundação Oswaldo Cruz (FIOCRUZ) |
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MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
_version_ |
1798324921479200768 |