Association between occupational exposure to benzene and chromosomal alterations in lymphocytes of Brazilian petrochemical workers removed from exposure

Detalhes bibliográficos
Autor(a) principal: Gonçalves, Rozana Oliveira
Data de Publicação: 2016
Outros Autores: Melo, Neli de Almeida, Rêgo, Marco Antônio Vasconcelos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16457
Resumo: The National Council for Scientific and Technological Development—CNPq (process number 478-068-2003-4), the Gonçalo Moniz Research Center, and the Health Department of the State of Bahia/Workers Health Study Center–CESAT
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spelling Gonçalves, Rozana OliveiraMelo, Neli de AlmeidaRêgo, Marco Antônio Vasconcelos2016-12-06T19:10:19Z2016-12-06T19:10:19Z2016GONÇALVES, R. O.; MELO, N. A.; RÊGO, M. A. V. Association between occupational exposure to benzene and chromosomal alterations in lymphocytes of Brazilian petrochemical workers removed from exposure. Environmental Monitoring and Assessment, v. 188, p. 334, 2016.0167-6369https://www.arca.fiocruz.br/handle/icict/1645710.1007/s10661-016-5340-1The National Council for Scientific and Technological Development—CNPq (process number 478-068-2003-4), the Gonçalo Moniz Research Center, and the Health Department of the State of Bahia/Workers Health Study Center–CESATFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilFederal University Bahia. Department of Preventive and Social. Salvador, BA, BrasilWe aimed to investigate the association between chronic exposure to benzene and genotoxicity in the lymphocytes of workers removed from exposure. The study included 20 workers with hematological disorders who had previously worked in the petrochemical industry of Salvador, Bahia, Brazil; 16 workers without occupational exposure to benzene served as the control group. Chromosomal analysis was performed on lymphocytes from peripheral blood, to assess chromosomal breaks and gaps and to identify aneuploidy. The Kruskal-Wallis test was used to compare the mean values between two groups, and Student's t test for comparison of two independent means. The frequency of gaps was statistically higher in and the exposed group than in the controls (2.13 ± 2.86 vs. 0.97 ± 1.27, p = 0.001). The frequency of chromosomal breaks was significantly higher among cases (0.21 ± 0.58) than among controls (0.12 ± 0.4) (p = 0.0002). An association was observed between chromosomal gaps and breaks and occupational exposure to benzene. Our study showed that even when removed from exposure for several years, workers still demonstrated genotoxic damage. Studies are still needed to clarify the long-term genotoxic potential of benzene after removal from exposure.engSpringer VerlagExposição profissionalBenzeno Aberrações cromossómicasAneuploidiaOccupational exposureBenzene Chromosomal aberrationsAneuploidyAssociation between occupational exposure to benzene and chromosomal alterations in lymphocytes of Brazilian petrochemical workers removed from exposureinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16457/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGonçalves RO Association between occupational....pdfGonçalves RO Association between 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dc.title.pt_BR.fl_str_mv Association between occupational exposure to benzene and chromosomal alterations in lymphocytes of Brazilian petrochemical workers removed from exposure
title Association between occupational exposure to benzene and chromosomal alterations in lymphocytes of Brazilian petrochemical workers removed from exposure
spellingShingle Association between occupational exposure to benzene and chromosomal alterations in lymphocytes of Brazilian petrochemical workers removed from exposure
Gonçalves, Rozana Oliveira
Exposição profissional
Benzeno Aberrações cromossómicas
Aneuploidia
Occupational exposure
Benzene Chromosomal aberrations
Aneuploidy
title_short Association between occupational exposure to benzene and chromosomal alterations in lymphocytes of Brazilian petrochemical workers removed from exposure
title_full Association between occupational exposure to benzene and chromosomal alterations in lymphocytes of Brazilian petrochemical workers removed from exposure
title_fullStr Association between occupational exposure to benzene and chromosomal alterations in lymphocytes of Brazilian petrochemical workers removed from exposure
title_full_unstemmed Association between occupational exposure to benzene and chromosomal alterations in lymphocytes of Brazilian petrochemical workers removed from exposure
title_sort Association between occupational exposure to benzene and chromosomal alterations in lymphocytes of Brazilian petrochemical workers removed from exposure
author Gonçalves, Rozana Oliveira
author_facet Gonçalves, Rozana Oliveira
Melo, Neli de Almeida
Rêgo, Marco Antônio Vasconcelos
author_role author
author2 Melo, Neli de Almeida
Rêgo, Marco Antônio Vasconcelos
author2_role author
author
dc.contributor.author.fl_str_mv Gonçalves, Rozana Oliveira
Melo, Neli de Almeida
Rêgo, Marco Antônio Vasconcelos
dc.subject.other.pt_BR.fl_str_mv Exposição profissional
Benzeno Aberrações cromossómicas
Aneuploidia
topic Exposição profissional
Benzeno Aberrações cromossómicas
Aneuploidia
Occupational exposure
Benzene Chromosomal aberrations
Aneuploidy
dc.subject.en.pt_BR.fl_str_mv Occupational exposure
Benzene Chromosomal aberrations
Aneuploidy
description The National Council for Scientific and Technological Development—CNPq (process number 478-068-2003-4), the Gonçalo Moniz Research Center, and the Health Department of the State of Bahia/Workers Health Study Center–CESAT
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-12-06T19:10:19Z
dc.date.available.fl_str_mv 2016-12-06T19:10:19Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv GONÇALVES, R. O.; MELO, N. A.; RÊGO, M. A. V. Association between occupational exposure to benzene and chromosomal alterations in lymphocytes of Brazilian petrochemical workers removed from exposure. Environmental Monitoring and Assessment, v. 188, p. 334, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16457
dc.identifier.issn.pt_BR.fl_str_mv 0167-6369
dc.identifier.doi.none.fl_str_mv 10.1007/s10661-016-5340-1
identifier_str_mv GONÇALVES, R. O.; MELO, N. A.; RÊGO, M. A. V. Association between occupational exposure to benzene and chromosomal alterations in lymphocytes of Brazilian petrochemical workers removed from exposure. Environmental Monitoring and Assessment, v. 188, p. 334, 2016.
0167-6369
10.1007/s10661-016-5340-1
url https://www.arca.fiocruz.br/handle/icict/16457
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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