Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors

Detalhes bibliográficos
Autor(a) principal: López-Camacho, César
Data de Publicação: 2018
Outros Autores: Abbink, Peter, Larocca, Rafael A., Dejnirattisai, Wanwisa, Boyd, Michael, Badamchi-Zadeh, Alex, Wallace, Zoë R., Doig, Jennifer, Velazquez, Ricardo Sanchez, Neto, Roberto Dias Lins, Coelho, Danilo F., Kim, Young Chan, Donald, Claire L., Owsianka, Ania, De Lorenzo, Giuditta, Kohl, Alain, Gilbert, Sarah C., Dorrell, Lucy, Mongkolsapaya, Juthathip, Patel, Arvind H., Screaton, Gavin R., Barouch, Dan H., Hill, Adrian V. S., Reyes-Sandoval, Arturo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27760
Resumo: 1The Jenner Institute, Nuffield Department of Medicine, University of Oxford, The Henry Wellcome Building for Molecular Physiology, Roosevelt Drive, Oxford, OX3 7BN UK 2Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 USA 3Division of Immunology and Inflammation, Department of Medicine, Hammersmith Campus, Imperial College London, London, W12 0NN UK 4Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, OX3 7FZ UK 5MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow,, G61 1QH Scotland UK 6Aggeu Magalhães Institute, Oswaldo Cruz Foundation, 50670-465 Recife, Brazil 7The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK 8Dengue Hemorrhagic Fever Research Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700 Thailand 9Division of Medical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU UK
id CRUZ_00824f60627411dbe0e851bac1e56c1c
oai_identifier_str oai:www.arca.fiocruz.br:icict/27760
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling López-Camacho, CésarAbbink, PeterLarocca, Rafael A.Dejnirattisai, WanwisaBoyd, MichaelBadamchi-Zadeh, AlexWallace, Zoë R.Doig, JenniferVelazquez, Ricardo SanchezNeto, Roberto Dias LinsCoelho, Danilo F.Kim, Young ChanDonald, Claire L.Owsianka, AniaDe Lorenzo, GiudittaKohl, AlainGilbert, Sarah C.Dorrell, LucyMongkolsapaya, JuthathipPatel, Arvind H.Screaton, Gavin R.Barouch, Dan H.Hill, Adrian V. S.Reyes-Sandoval, Arturo2018-08-01T14:06:34Z2018-08-01T14:06:34Z2018LÓPEZ-CAMACHO, C. et al. Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors. Nature Communications, v. 9, n. 1, p. 1-11, 22 Jun. 2018.2041-1723https://www.arca.fiocruz.br/handle/icict/2776010.1038/s41467-018-04859-51The Jenner Institute, Nuffield Department of Medicine, University of Oxford, The Henry Wellcome Building for Molecular Physiology, Roosevelt Drive, Oxford, OX3 7BN UK 2Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 USA 3Division of Immunology and Inflammation, Department of Medicine, Hammersmith Campus, Imperial College London, London, W12 0NN UK 4Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, OX3 7FZ UK 5MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow,, G61 1QH Scotland UK 6Aggeu Magalhães Institute, Oswaldo Cruz Foundation, 50670-465 Recife, Brazil 7The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK 8Dengue Hemorrhagic Fever Research Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700 Thailand 9Division of Medical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU UKConselho de Pesquisa Médica do Reino Unido [MC_UU_12014 (AHP e AK ) e MR / N017552 / 1 (AK)]. Juthathip Mongkolsapaya é apoiado por uma bolsa do Fundo MRC-Newton, Gavin Screaton é um investigador sênior da Wellcome Trust.Múltipla - ver em NotasZika virus (ZIKV) emerged on a global scale and no licensed vaccine ensures long-lasting anti-ZIKV immunity. Here we report the design and comparative evaluation of four replication-deficient chimpanzee adenoviral (ChAdOx1) ZIKV vaccine candidates comprising the addition or deletion of precursor membrane (prM) and envelope, with or without its transmembrane domain (TM). A single, non-adjuvanted vaccination of ChAdOx1 ZIKV vaccines elicits suitable levels of protective responses in mice challenged with ZIKV. ChAdOx1 prME ∆TM encoding prM and envelope without TM provides 100% protection, as well as long-lasting anti-envelope immune responses and no evidence of in vitro antibody-dependent enhancement to dengue virus. Deletion of prM and addition of TM reduces protective efficacy and yields lower anti-envelope responses. Our finding that immunity against ZIKV can be enhanced by modulating antigen membrane anchoring highlights important parameters in the design of viral vectored ZIKV vaccines to support further clinical assessments.engVírus ZikaVacinaResposta imuneZika virusVaccineImmune responseRational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectorsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83092https://www.arca.fiocruz.br/bitstream/icict/27760/1/license.txt447f2497af1ef5cf99b5c07f6fa18dceMD51ORIGINALIAM - Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors.pdfIAM - Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors.pdfapplication/pdf1934758https://www.arca.fiocruz.br/bitstream/icict/27760/2/IAM%20-%20Rational%20Zika%20vaccine%20design%20via%20the%20modulation%20of%20antigen%20membrane%20anchors%20in%20chimpanzee%20adenoviral%20vectors.pdfcaad354ba79c79d77e64a0eef4ee519bMD52TEXTIAM - Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors.pdf.txtIAM - Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors.pdf.txtExtracted texttext/plain64232https://www.arca.fiocruz.br/bitstream/icict/27760/3/IAM%20-%20Rational%20Zika%20vaccine%20design%20via%20the%20modulation%20of%20antigen%20membrane%20anchors%20in%20chimpanzee%20adenoviral%20vectors.pdf.txt67c79070e6c870b87f25bf9bf49db603MD53icict/277602018-08-15 03:23:59.042oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-08-15T06:23:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
title Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
spellingShingle Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
López-Camacho, César
Vírus Zika
Vacina
Resposta imune
Zika virus
Vaccine
Immune response
title_short Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
title_full Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
title_fullStr Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
title_full_unstemmed Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
title_sort Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
author López-Camacho, César
author_facet López-Camacho, César
Abbink, Peter
Larocca, Rafael A.
Dejnirattisai, Wanwisa
Boyd, Michael
Badamchi-Zadeh, Alex
Wallace, Zoë R.
Doig, Jennifer
Velazquez, Ricardo Sanchez
Neto, Roberto Dias Lins
Coelho, Danilo F.
Kim, Young Chan
Donald, Claire L.
Owsianka, Ania
De Lorenzo, Giuditta
Kohl, Alain
Gilbert, Sarah C.
Dorrell, Lucy
Mongkolsapaya, Juthathip
Patel, Arvind H.
Screaton, Gavin R.
Barouch, Dan H.
Hill, Adrian V. S.
Reyes-Sandoval, Arturo
author_role author
author2 Abbink, Peter
Larocca, Rafael A.
Dejnirattisai, Wanwisa
Boyd, Michael
Badamchi-Zadeh, Alex
Wallace, Zoë R.
Doig, Jennifer
Velazquez, Ricardo Sanchez
Neto, Roberto Dias Lins
Coelho, Danilo F.
Kim, Young Chan
Donald, Claire L.
Owsianka, Ania
De Lorenzo, Giuditta
Kohl, Alain
Gilbert, Sarah C.
Dorrell, Lucy
Mongkolsapaya, Juthathip
Patel, Arvind H.
Screaton, Gavin R.
Barouch, Dan H.
Hill, Adrian V. S.
Reyes-Sandoval, Arturo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv López-Camacho, César
Abbink, Peter
Larocca, Rafael A.
Dejnirattisai, Wanwisa
Boyd, Michael
Badamchi-Zadeh, Alex
Wallace, Zoë R.
Doig, Jennifer
Velazquez, Ricardo Sanchez
Neto, Roberto Dias Lins
Coelho, Danilo F.
Kim, Young Chan
Donald, Claire L.
Owsianka, Ania
De Lorenzo, Giuditta
Kohl, Alain
Gilbert, Sarah C.
Dorrell, Lucy
Mongkolsapaya, Juthathip
Patel, Arvind H.
Screaton, Gavin R.
Barouch, Dan H.
Hill, Adrian V. S.
Reyes-Sandoval, Arturo
dc.subject.other.pt_BR.fl_str_mv Vírus Zika
Vacina
Resposta imune
topic Vírus Zika
Vacina
Resposta imune
Zika virus
Vaccine
Immune response
dc.subject.en.pt_BR.fl_str_mv Zika virus
Vaccine
Immune response
description 1The Jenner Institute, Nuffield Department of Medicine, University of Oxford, The Henry Wellcome Building for Molecular Physiology, Roosevelt Drive, Oxford, OX3 7BN UK 2Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215 USA 3Division of Immunology and Inflammation, Department of Medicine, Hammersmith Campus, Imperial College London, London, W12 0NN UK 4Nuffield Department of Medicine and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, OX3 7FZ UK 5MRC-University of Glasgow Centre for Virus Research, University of Glasgow, Glasgow,, G61 1QH Scotland UK 6Aggeu Magalhães Institute, Oswaldo Cruz Foundation, 50670-465 Recife, Brazil 7The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK 8Dengue Hemorrhagic Fever Research Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700 Thailand 9Division of Medical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU UK
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-08-01T14:06:34Z
dc.date.available.fl_str_mv 2018-08-01T14:06:34Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LÓPEZ-CAMACHO, C. et al. Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors. Nature Communications, v. 9, n. 1, p. 1-11, 22 Jun. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27760
dc.identifier.issn.pt_BR.fl_str_mv 2041-1723
dc.identifier.doi.none.fl_str_mv 10.1038/s41467-018-04859-5
identifier_str_mv LÓPEZ-CAMACHO, C. et al. Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors. Nature Communications, v. 9, n. 1, p. 1-11, 22 Jun. 2018.
2041-1723
10.1038/s41467-018-04859-5
url https://www.arca.fiocruz.br/handle/icict/27760
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/27760/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/27760/2/IAM%20-%20Rational%20Zika%20vaccine%20design%20via%20the%20modulation%20of%20antigen%20membrane%20anchors%20in%20chimpanzee%20adenoviral%20vectors.pdf
https://www.arca.fiocruz.br/bitstream/icict/27760/3/IAM%20-%20Rational%20Zika%20vaccine%20design%20via%20the%20modulation%20of%20antigen%20membrane%20anchors%20in%20chimpanzee%20adenoviral%20vectors.pdf.txt
bitstream.checksum.fl_str_mv 447f2497af1ef5cf99b5c07f6fa18dce
caad354ba79c79d77e64a0eef4ee519b
67c79070e6c870b87f25bf9bf49db603
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009014256041984