Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy

Detalhes bibliográficos
Autor(a) principal: Silva, Valdenizia Rodrigues
Data de Publicação: 2020
Outros Autores: Neves, Sara Parente, Santos, Luciano de S., Dias, Rosane Borges, Bezerra, Daniel Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/46084
Resumo: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (grant number 001, CAPES, Brazil), and D.P.B. receives a personal scholarship from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil).
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spelling Silva, Valdenizia RodriguesNeves, Sara ParenteSantos, Luciano de S.Dias, Rosane BorgesBezerra, Daniel Pereira2021-02-16T12:50:37Z2021-02-16T12:50:37Z2020SILVA, Valdenizia Rodrigues et al. Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy. Cancers, v. 12, p. 1-36, 2020.2072-6694https://www.arca.fiocruz.br/handle/icict/4608410.3390/cancers12113461Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (grant number 001, CAPES, Brazil), and D.P.B. receives a personal scholarship from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Autophagy is a physiological cellular process that is crucial for development and can occurs in response to nutrient deprivation or metabolic disorders. Interestingly, autophagy plays a dual role in cancer cells—while in some situations, it has a cytoprotective e ect that causes chemotherapy resistance, in others, it has a cytotoxic e ect in which some compounds induce autophagy-mediated cell death. In this review, we summarize strategies aimed at autophagy for the treatment of cancer, including studies of drugs that can modulate autophagy-mediated resistance, and/or drugs that cause autophagy-mediated cancer cell death. In addition, the role of autophagy in the biology of cancer stem cells has also been discussed.engMDPIautofagiaACâncerMorte celularResistência a drogaAutophagyCancerCell deathDrug resistanceChallenges and Therapeutic Opportunities of Autophagy in Cancer Therapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/46084/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALSILVA et al Challenges and Therapeutic... 2020 v.12 n.11 pg.1-36.pdfSILVA et al Challenges and Therapeutic... 2020 v.12 n.11 pg.1-36.pdfapplication/pdf2875701https://www.arca.fiocruz.br/bitstream/icict/46084/2/SILVA%20et%20al%20Challenges%20and%20Therapeutic...%202020%20v.12%20n.11%20pg.1-36.pdf893c6780547629c42774c197c2eb1ce2MD52TEXTSILVA et al Challenges and 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dc.title.pt_BR.fl_str_mv Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy
title Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy
spellingShingle Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy
Silva, Valdenizia Rodrigues
autofagiaA
Câncer
Morte celular
Resistência a droga
Autophagy
Cancer
Cell death
Drug resistance
title_short Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy
title_full Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy
title_fullStr Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy
title_full_unstemmed Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy
title_sort Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy
author Silva, Valdenizia Rodrigues
author_facet Silva, Valdenizia Rodrigues
Neves, Sara Parente
Santos, Luciano de S.
Dias, Rosane Borges
Bezerra, Daniel Pereira
author_role author
author2 Neves, Sara Parente
Santos, Luciano de S.
Dias, Rosane Borges
Bezerra, Daniel Pereira
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva, Valdenizia Rodrigues
Neves, Sara Parente
Santos, Luciano de S.
Dias, Rosane Borges
Bezerra, Daniel Pereira
dc.subject.other.pt_BR.fl_str_mv autofagiaA
Câncer
Morte celular
Resistência a droga
topic autofagiaA
Câncer
Morte celular
Resistência a droga
Autophagy
Cancer
Cell death
Drug resistance
dc.subject.en.pt_BR.fl_str_mv Autophagy
Cancer
Cell death
Drug resistance
description Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (grant number 001, CAPES, Brazil), and D.P.B. receives a personal scholarship from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil).
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2021-02-16T12:50:37Z
dc.date.available.fl_str_mv 2021-02-16T12:50:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Valdenizia Rodrigues et al. Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy. Cancers, v. 12, p. 1-36, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/46084
dc.identifier.issn.pt_BR.fl_str_mv 2072-6694
dc.identifier.doi.none.fl_str_mv 10.3390/cancers12113461
identifier_str_mv SILVA, Valdenizia Rodrigues et al. Challenges and Therapeutic Opportunities of Autophagy in Cancer Therapy. Cancers, v. 12, p. 1-36, 2020.
2072-6694
10.3390/cancers12113461
url https://www.arca.fiocruz.br/handle/icict/46084
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/46084/1/license.txt
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