Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection

Detalhes bibliográficos
Autor(a) principal: Souza, Claudia Teresa Vieira de
Data de Publicação: 2021
Outros Autores: Teixeira, Maria de Lourdes Benamor, Gouvêa, Maria Isabel Fragoso da Silveira, Milnor, Jacob, Lima Filho, Jose Berilo de, Quintana, Marcel de Souza Borges, Rolla, Valéria Cavalcanti
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50237
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Epidemiologia e Determinação Social da Saúde. Rio de Janeiro, RJ, Brasil.
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spelling Souza, Claudia Teresa Vieira deTeixeira, Maria de Lourdes BenamorGouvêa, Maria Isabel Fragoso da SilveiraMilnor, JacobLima Filho, Jose Berilo deQuintana, Marcel de Souza BorgesRolla, Valéria Cavalcanti2021-12-09T13:32:21Z2021-12-09T13:32:21Z2021SOUZA, Claudia Teresa Vieira de et al. Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection. Revista de Patologia Tropical, v. 50, n. 3, p. 201-211, July/Sept. 2021.0301-0406https://www.arca.fiocruz.br/handle/icict/5023710.5216/rpt.v50i3.685741980-8178engUniversidade Federal de GoiásTuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Epidemiologia e Determinação Social da Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Epidemiologia e Determinação Social da Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Epidemiologia e Determinação Social da Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço de Informação e Estatística. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Plataforma de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil.Tuberculosis is the leading cause of death amongst adults with human immunodeficiency virus (HIV) infection. The lifetime risk of tuberculosis disease for a person with latent infection is estimated at 5-10% with most cases occurring within five years of initial infection. The World Health Organization recommends isoniazid preventive therapy (IPT) for latent tuberculosis treatment, amongst other strategies. The aim was to assess tuberculosis incidence, survival (free of tuberculosis) and associated factors in HIV-positive patients. IPT was offered to participants with a positive (≥5mm) tuberculin skin test. Participants were followed from February 2003-December 2016. Kaplan-Meier was used for survival analysis. Variables with p-value ≤ 0.2 in the univariate analysis entered into the multivariate Cox-Model, keeping those with p-value ≤ 0.05. The 95% confidence interval of incidence of tuberculosis was estimated using Poisson distribution. One hundred nineteen patients completed the IPT and were followed for a median duration of 110.7 months (IQR 93.1-121.0). The probability of developing tuberculosis (10 years post-IPT) was 5.4%. Tuberculosis incidence was 0.58/100 patient/years (CI 95% 0.213-1.264). IPT over 6 months provided long-term protection against tuberculosis. AIDS-defining illness was the only statistically significant variable (HR=5.67) in the multivariate model.Latent tuberculosisHIVIsoniazidSurvival analysisTuberculose LatenteHIVIsoniazidaAnálise de Sobrevidainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83132https://www.arca.fiocruz.br/bitstream/icict/50237/1/license.txt33967fcc8ef681b8f5c2c34178ebc114MD51ORIGINALve_Claudia_Souza_etal_INI_2021.pdfve_Claudia_Souza_etal_INI_2021.pdfapplication/pdf543266https://www.arca.fiocruz.br/bitstream/icict/50237/2/ve_Claudia_Souza_etal_INI_2021.pdfce22f42843566983c2fee5e5ce4f81a1MD52icict/502372022-06-24 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dc.title.en_US.fl_str_mv Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection
title Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection
spellingShingle Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection
Souza, Claudia Teresa Vieira de
Latent tuberculosis
HIV
Isoniazid
Survival analysis
Tuberculose Latente
HIV
Isoniazida
Análise de Sobrevida
title_short Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection
title_full Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection
title_fullStr Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection
title_full_unstemmed Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection
title_sort Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection
author Souza, Claudia Teresa Vieira de
author_facet Souza, Claudia Teresa Vieira de
Teixeira, Maria de Lourdes Benamor
Gouvêa, Maria Isabel Fragoso da Silveira
Milnor, Jacob
Lima Filho, Jose Berilo de
Quintana, Marcel de Souza Borges
Rolla, Valéria Cavalcanti
author_role author
author2 Teixeira, Maria de Lourdes Benamor
Gouvêa, Maria Isabel Fragoso da Silveira
Milnor, Jacob
Lima Filho, Jose Berilo de
Quintana, Marcel de Souza Borges
Rolla, Valéria Cavalcanti
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Souza, Claudia Teresa Vieira de
Teixeira, Maria de Lourdes Benamor
Gouvêa, Maria Isabel Fragoso da Silveira
Milnor, Jacob
Lima Filho, Jose Berilo de
Quintana, Marcel de Souza Borges
Rolla, Valéria Cavalcanti
dc.subject.en.en_US.fl_str_mv Latent tuberculosis
HIV
Isoniazid
Survival analysis
topic Latent tuberculosis
HIV
Isoniazid
Survival analysis
Tuberculose Latente
HIV
Isoniazida
Análise de Sobrevida
dc.subject.decs.pt_BR.fl_str_mv Tuberculose Latente
HIV
Isoniazida
Análise de Sobrevida
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Epidemiologia e Determinação Social da Saúde. Rio de Janeiro, RJ, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-09T13:32:21Z
dc.date.available.fl_str_mv 2021-12-09T13:32:21Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SOUZA, Claudia Teresa Vieira de et al. Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection. Revista de Patologia Tropical, v. 50, n. 3, p. 201-211, July/Sept. 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50237
dc.identifier.issn.pt_BR.fl_str_mv 0301-0406
dc.identifier.doi.pt_BR.fl_str_mv 10.5216/rpt.v50i3.68574
dc.identifier.eissn.pt_BR.fl_str_mv 1980-8178
identifier_str_mv SOUZA, Claudia Teresa Vieira de et al. Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection. Revista de Patologia Tropical, v. 50, n. 3, p. 201-211, July/Sept. 2021.
0301-0406
10.5216/rpt.v50i3.68574
1980-8178
url https://www.arca.fiocruz.br/handle/icict/50237
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal de Goiás
publisher.none.fl_str_mv Universidade Federal de Goiás
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50237/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50237/2/ve_Claudia_Souza_etal_INI_2021.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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