Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/50237 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Epidemiologia e Determinação Social da Saúde. Rio de Janeiro, RJ, Brasil. |
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Souza, Claudia Teresa Vieira deTeixeira, Maria de Lourdes BenamorGouvêa, Maria Isabel Fragoso da SilveiraMilnor, JacobLima Filho, Jose Berilo deQuintana, Marcel de Souza BorgesRolla, Valéria Cavalcanti2021-12-09T13:32:21Z2021-12-09T13:32:21Z2021SOUZA, Claudia Teresa Vieira de et al. Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection. Revista de Patologia Tropical, v. 50, n. 3, p. 201-211, July/Sept. 2021.0301-0406https://www.arca.fiocruz.br/handle/icict/5023710.5216/rpt.v50i3.685741980-8178engUniversidade Federal de GoiásTuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Epidemiologia e Determinação Social da Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Epidemiologia e Determinação Social da Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Epidemiologia e Determinação Social da Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Serviço de Informação e Estatística. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Plataforma de Pesquisa Clínica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacterioses. Rio de Janeiro, RJ, Brasil.Tuberculosis is the leading cause of death amongst adults with human immunodeficiency virus (HIV) infection. The lifetime risk of tuberculosis disease for a person with latent infection is estimated at 5-10% with most cases occurring within five years of initial infection. The World Health Organization recommends isoniazid preventive therapy (IPT) for latent tuberculosis treatment, amongst other strategies. The aim was to assess tuberculosis incidence, survival (free of tuberculosis) and associated factors in HIV-positive patients. IPT was offered to participants with a positive (≥5mm) tuberculin skin test. Participants were followed from February 2003-December 2016. Kaplan-Meier was used for survival analysis. Variables with p-value ≤ 0.2 in the univariate analysis entered into the multivariate Cox-Model, keeping those with p-value ≤ 0.05. The 95% confidence interval of incidence of tuberculosis was estimated using Poisson distribution. One hundred nineteen patients completed the IPT and were followed for a median duration of 110.7 months (IQR 93.1-121.0). The probability of developing tuberculosis (10 years post-IPT) was 5.4%. Tuberculosis incidence was 0.58/100 patient/years (CI 95% 0.213-1.264). IPT over 6 months provided long-term protection against tuberculosis. AIDS-defining illness was the only statistically significant variable (HR=5.67) in the multivariate model.Latent tuberculosisHIVIsoniazidSurvival analysisTuberculose LatenteHIVIsoniazidaAnálise de Sobrevidainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83132https://www.arca.fiocruz.br/bitstream/icict/50237/1/license.txt33967fcc8ef681b8f5c2c34178ebc114MD51ORIGINALve_Claudia_Souza_etal_INI_2021.pdfve_Claudia_Souza_etal_INI_2021.pdfapplication/pdf543266https://www.arca.fiocruz.br/bitstream/icict/50237/2/ve_Claudia_Souza_etal_INI_2021.pdfce22f42843566983c2fee5e5ce4f81a1MD52icict/502372022-06-24 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dc.title.en_US.fl_str_mv |
Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection |
title |
Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection |
spellingShingle |
Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection Souza, Claudia Teresa Vieira de Latent tuberculosis HIV Isoniazid Survival analysis Tuberculose Latente HIV Isoniazida Análise de Sobrevida |
title_short |
Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection |
title_full |
Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection |
title_fullStr |
Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection |
title_full_unstemmed |
Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection |
title_sort |
Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection |
author |
Souza, Claudia Teresa Vieira de |
author_facet |
Souza, Claudia Teresa Vieira de Teixeira, Maria de Lourdes Benamor Gouvêa, Maria Isabel Fragoso da Silveira Milnor, Jacob Lima Filho, Jose Berilo de Quintana, Marcel de Souza Borges Rolla, Valéria Cavalcanti |
author_role |
author |
author2 |
Teixeira, Maria de Lourdes Benamor Gouvêa, Maria Isabel Fragoso da Silveira Milnor, Jacob Lima Filho, Jose Berilo de Quintana, Marcel de Souza Borges Rolla, Valéria Cavalcanti |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Souza, Claudia Teresa Vieira de Teixeira, Maria de Lourdes Benamor Gouvêa, Maria Isabel Fragoso da Silveira Milnor, Jacob Lima Filho, Jose Berilo de Quintana, Marcel de Souza Borges Rolla, Valéria Cavalcanti |
dc.subject.en.en_US.fl_str_mv |
Latent tuberculosis HIV Isoniazid Survival analysis |
topic |
Latent tuberculosis HIV Isoniazid Survival analysis Tuberculose Latente HIV Isoniazida Análise de Sobrevida |
dc.subject.decs.pt_BR.fl_str_mv |
Tuberculose Latente HIV Isoniazida Análise de Sobrevida |
description |
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa em Epidemiologia e Determinação Social da Saúde. Rio de Janeiro, RJ, Brasil. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-12-09T13:32:21Z |
dc.date.available.fl_str_mv |
2021-12-09T13:32:21Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SOUZA, Claudia Teresa Vieira de et al. Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection. Revista de Patologia Tropical, v. 50, n. 3, p. 201-211, July/Sept. 2021. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/50237 |
dc.identifier.issn.pt_BR.fl_str_mv |
0301-0406 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.5216/rpt.v50i3.68574 |
dc.identifier.eissn.pt_BR.fl_str_mv |
1980-8178 |
identifier_str_mv |
SOUZA, Claudia Teresa Vieira de et al. Tuberculosis incidence in patients with human immunodeficiency virus, treated with isoniazid for latent tuberculosis infection. Revista de Patologia Tropical, v. 50, n. 3, p. 201-211, July/Sept. 2021. 0301-0406 10.5216/rpt.v50i3.68574 1980-8178 |
url |
https://www.arca.fiocruz.br/handle/icict/50237 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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