Long-term CD4+ cell count in response to combination antiretroviral therapy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1371/journal.pone.0093039 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10498 |
Resumo: | CNPq, FAPERJ, NIH |
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Luz, Paula MendesGrinsztejn, BeatrizVelasque, Luciane de SouzaPacheco, Antonio Guilherme FonsecaSantos, Valdiléa Gonçalves Veloso dosMoore, Richard D.Struchiner, Claudio Jose2015-05-26T17:03:30Z2015-05-26T17:03:30Z2014LUZ, Paula Mendes et al. Long-term CD4+ cell count in response to combination antiretroviral therapy. Plos One, v. 9, n. 4, p. 1-11, Apr. 2014.1932-6203https://www.arca.fiocruz.br/handle/icict/1049810.1371/journal.pone.00930391932-6203CNPq, FAPERJ, NIHFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Departamento de Matemática e Estatística. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Johns Hopkins University. Department of Medicine. Baltimore, MD, USA.Fundação Oswaldo Cruz. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Objective: There is a continuous debate on how to adequately evaluate long-term CD4+ cell count in response to combination antiretroviral therapy (ART) among human immunodeficiency virus (HIV)-infected individuals. Our study evaluated the long-term CD4+ cell count response (up to ten years) after initiation of ART and described the differences in the CD4+ cell count response stratified by pretreatment CD4+ cell count, and other socio-demographic, behavioral, and clinical factors. Methods: The study population included patients starting ART in the clinical cohorts of Rio de Janeiro, Brazil, and Baltimore, United States. Inverse probability of censoring weighting was used to estimate mean annual CD4+ cell counts while adjusting for choice of initial ART regimen, ART discontinuation and losses-to-follow-up. Results: From 1997 to 2011, 3116 individuals started ART; preferred initial regimen was NNRTI-based (63%). The median follow-up time was 5 years, 10% of the individuals had nine or more years of follow-up. Observed CD4+ cell counts increased throughout the ten years of follow-up. Weighted results, in contrast, increased up to year four and plateaued thereafter with 50% of the population reaching CD4+ cell counts of 449/mL or more. Out of all stratification variables considered, only individuals with pre-treatment CD4+ cell counts $350/mL showed increasing CD4+ cell counts over time with 76% surpassing the CD4+ cell count .500/mL threshold at year ten. Conclusion: The present study corroborates the growing body of knowledge advocating early start of ART by showing that only patients who start ART early fully recover to normal CD4+ cell counts.engPublic Library of ScienceRio de JaneiroHIVCD4 antigensHighly active antiretroviral therapyBaltimore/ethnologyBrazil/ethnologyHIVAntígenos CD4Terapia antirretroviral de alta atividadeBaltimore/etnologiaBrasil/etnologiaLong-term CD4+ cell count in response to combination antiretroviral therapyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10498/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALLong-Term CD4+ Cell Count in Response to Combination Antiretroviral Therapy.pdfLong-Term CD4+ Cell Count in Response to Combination Antiretroviral Therapy.pdfapplication/pdf768634https://www.arca.fiocruz.br/bitstream/icict/10498/2/Long-Term%20CD4%2b%20Cell%20Count%20in%20Response%20to%20Combination%20Antiretroviral%20Therapy.pdf9006a1613eef4c6b8a2865013e590912MD52TEXTLong-Term CD4+ Cell Count in Response to Combination Antiretroviral Therapy.pdf.txtLong-Term CD4+ Cell Count in Response to Combination Antiretroviral Therapy.pdf.txtExtracted texttext/plain49060https://www.arca.fiocruz.br/bitstream/icict/10498/3/Long-Term%20CD4%2b%20Cell%20Count%20in%20Response%20to%20Combination%20Antiretroviral%20Therapy.pdf.txt523927ba096b3ff2712ff9b2e346884dMD53icict/104982023-06-15 16:17:35.338oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-06-15T19:17:35Repositório Institucional da FIOCRUZ (ARCA) - 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| dc.title.pt_BR.fl_str_mv |
Long-term CD4+ cell count in response to combination antiretroviral therapy |
| title |
Long-term CD4+ cell count in response to combination antiretroviral therapy |
| spellingShingle |
Long-term CD4+ cell count in response to combination antiretroviral therapy Luz, Paula Mendes Rio de Janeiro HIV CD4 antigens Highly active antiretroviral therapy Baltimore/ethnology Brazil/ethnology HIV Antígenos CD4 Terapia antirretroviral de alta atividade Baltimore/etnologia Brasil/etnologia |
| title_short |
Long-term CD4+ cell count in response to combination antiretroviral therapy |
| title_full |
Long-term CD4+ cell count in response to combination antiretroviral therapy |
| title_fullStr |
Long-term CD4+ cell count in response to combination antiretroviral therapy |
| title_full_unstemmed |
Long-term CD4+ cell count in response to combination antiretroviral therapy |
| title_sort |
Long-term CD4+ cell count in response to combination antiretroviral therapy |
| author |
Luz, Paula Mendes |
| author_facet |
Luz, Paula Mendes Grinsztejn, Beatriz Velasque, Luciane de Souza Pacheco, Antonio Guilherme Fonseca Santos, Valdiléa Gonçalves Veloso dos Moore, Richard D. Struchiner, Claudio Jose |
| author_role |
author |
| author2 |
Grinsztejn, Beatriz Velasque, Luciane de Souza Pacheco, Antonio Guilherme Fonseca Santos, Valdiléa Gonçalves Veloso dos Moore, Richard D. Struchiner, Claudio Jose |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Luz, Paula Mendes Grinsztejn, Beatriz Velasque, Luciane de Souza Pacheco, Antonio Guilherme Fonseca Santos, Valdiléa Gonçalves Veloso dos Moore, Richard D. Struchiner, Claudio Jose |
| dc.subject.other.pt_BR.fl_str_mv |
Rio de Janeiro |
| topic |
Rio de Janeiro HIV CD4 antigens Highly active antiretroviral therapy Baltimore/ethnology Brazil/ethnology HIV Antígenos CD4 Terapia antirretroviral de alta atividade Baltimore/etnologia Brasil/etnologia |
| dc.subject.en.pt_BR.fl_str_mv |
HIV CD4 antigens Highly active antiretroviral therapy Baltimore/ethnology Brazil/ethnology |
| dc.subject.decs.pt_BR.fl_str_mv |
HIV Antígenos CD4 Terapia antirretroviral de alta atividade Baltimore/etnologia Brasil/etnologia |
| description |
CNPq, FAPERJ, NIH |
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2014 |
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2014 |
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2015-05-26T17:03:30Z |
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2015-05-26T17:03:30Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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LUZ, Paula Mendes et al. Long-term CD4+ cell count in response to combination antiretroviral therapy. Plos One, v. 9, n. 4, p. 1-11, Apr. 2014. |
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https://www.arca.fiocruz.br/handle/icict/10498 |
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1932-6203 |
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10.1371/journal.pone.0093039 |
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1932-6203 |
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LUZ, Paula Mendes et al. Long-term CD4+ cell count in response to combination antiretroviral therapy. Plos One, v. 9, n. 4, p. 1-11, Apr. 2014. 1932-6203 10.1371/journal.pone.0093039 |
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Public Library of Science |
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Public Library of Science |
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